Cyclic pentapeptide endothelin A receptor antagonists with attenuated in vivo clearance

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 3, 1996, Pages 609-614

  Fukami, Takehiro ^a   Niiyama, Kenji ^a   Amano, Yuuka ^a   Hisaka, Akihiro ^a   Fujino, Naoko ^a   Sawasaki, Yoshio ^a   Ihara, Masaki ^a   Ishikawa, Kiyofumi ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

BQ 123; cyclic pentapeptide; endothelin; endothelin antagonist; pharmacokinetic evaluation

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLHYDROXYPROLYLLYSYL DEXTRO VALYLLEUCYL); CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); CYCLO(DEXTRO TRYPTOPHYL DEXTRO HYDROXYPROLYLARGINYL DEXTRO VALYLLEUCYL); CYCLO[DEXTRO TRYPTOPHYL DEXTRO ASPARTYL(DIMETHYLLYSYLHYDROXYPROLYL) DEXTRO VALYLLEUCYL]; ENDOTHELIN; ENDOTHELIN A RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; PENTAPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHRONIC DISEASE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DEGRADATION; DRUG ISOLATION; DRUG METABOLISM; DRUG SYNTHESIS; INTRAVENOUS DRUG ADMINISTRATION; LIVER METABOLISM; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; VASCULAR DISEASE;

EID: 0029885699     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.609     Document Type: Article

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