Dichloroacetate enhanced myocardial functional recovery post-ischemia: ATP and NADH recovery

Journal of Surgical Research

Volumn 63, Issue 1, 1996, Pages 220-224

  Wahr, Joyce A ^a   Olszanski, Douglas ^a   Childs, Keith F ^a   Bolling, Steven F ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; DICHLOROACETIC ACID; LACTIC ACID; PYRUVATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; HEART MUSCLE BIOPSY; HEART MUSCLE ISCHEMIA; HEART MUSCLE OXYGEN CONSUMPTION; HEART PERFUSION; MALE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RABBIT;

EID: 0029885589     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0251     Document Type: Conference Paper

References (20)

1. Stacpoole, P. W. The pharmacology of dichloroacetate. Metabolism 38(11): 1124-1144, 1989.
2. Mjos, O. D., Miller, N. E., Riemersma, R. A., and Oliver, M. F. Effects of dichloroacetate on myocardial substrate extraction, epicardial ST-segment elevation, and ventricular blood flow following coronary occlusion in dogs. Cardiovasc. Res. 10: 427-436, 1976.
3. Burns, A. H., Summer, W. R., Burns, L. A. R., Shepherd, R. E. Inotropic interactions of dichloroacetate with amrinone and ouabain in isolated hearts from endotoxin-shocked rats. J. Cardiovasc. Pharmacol.2(4): 379-386, 1988.
4. Stacpoole, P. W., Harman, E. M., Curry, S. H., Baumgartner, T. G., Misbin, R. I. Treatment of lactic acidosis with dichloroacetate. New Engl. J. Med. 309: 390-396, 1983.
5. Stacpoole, P. W., Lorenz, A. C., Thomas, R. G., Harman, E. M. Dichloroacetate in the treatment of lactic acidosis. Ann. Intern. Med. 108: 58-631, 1988.
6. Wahr, J. A., Childs, K. F., Bolling, S. F. Dichloroacetate enhances myocardial functional and metabolic recovery following global ischemia. J. Cardiothorac. Vasc. Anes. 8: 192-197, 1994.
7. Foker, J. E., Einzig, S., Wang, T. Adenosine metabolism and myocardial preservation. J. Thorac. Cardiovasc. Surg. 80: 506-516, 1980.
8. Reibel, D. K., Rovetto, M. J. Myocardial adenosine salvage rates and restoration of ATP content following ischemia. Am. J. Physiol. 237(2): H247-H252, 1979.
9. Bolling, S. F., Bies, L. E., Gallagher, K. P., Bove, E. L. Enhanced myocardial protection with adenosine. Ann. Thorac. Surg. 47: 809-815, 1989.
10. Bolling, S. F., Bove, E. L., Gallagher, K. P. ATP precursor depletion and postischemic myocardial recovery. J. Surg. Res. 50: 629-633, 1991.
11. Naylor, W. G. The role of calcium in the ischemic myocardium. Am. J. Pathol. 102: 262-270, 1981.
12. Neely, J. R., Grotyohann, L. W. Role of glycolytic products in damage to ischemic myocardium: Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts. Circ. Res. 55: 816-824, 1984.
13. Racey-Burns, L. A., Burns, A. H., Summer, W. R., Shepherd, R. E. The effect of dichloroacetate on the isolated no flow arrested rat heart. Life Sci. 44: 2015-2023, 1989.
14. Myers, M. L., Bolli, R., Lekich, R. F., Hartley, C. J., Roberts, R. Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia. Circulation 72(4): 915-921, 1985.
15. McVeigh, J. J., Lopaschuk, G. D. Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts. Am. J. Physiol. 28: H1079-1085, 1990.
16. Mallet, R. T., Hartman, D. A., Bunger, R. Glucose requirement for postischemic recovery of perfused working heart. Eur. J. Biochem. 188: 481-493, 1990.
17. Wahr, J. A., Ullrich, K., Bolling, S. F. Metabolic and hemodynamic effects of dichloroacetate in the treatment of hypoxic lactic acidosis. J. Cardiothorac. Vasc. Anes. 8: 64-69, 1993.
18. Whitehouse, S., Cooper, R. H., Randle, P. J. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids. Biochem. J. 142: 761, 1974.
19. Kehrer, J. P., Lund, L. G. Cellular reducing equivalents and oxidative stress. Free Radical Biol. Med. 17: 65-75, 1994.
20. Janero, D. R., Hreniuk, D., Sharif, H. M., Prout, K. C. Hydroperoxide-induced oxidative stress alters pyridine nucleotide metabolism in neonatal heart muscle cells. Am. J. Physiol. 264: C1401-1410, 1993.