Synthesis of analogues of the benzodiazepine Ro 5-3335, antagonist of Tat HIV-1. Biological evaluation by luciferase transactivation and anti-viral assay

European Journal of Medicinal Chemistry

Volumn 31, Issue 6, 1996, Pages 497-505

  Farese, A ^a   Peytou, V ^a   Condom, R ^a   Sinet, M ^b   Patino, N ^a   Kirn, A ^b   Moog, C ^b   Aubertin, A M ^b   Guedj, R ^a  

^a UNIVERSITÉ CÔTE D'AZUR   (France)

^b INSERM   (France)

Author keywords

analogue; benzodiazepine; HIV 1; luciferase transactivation; Tat

Indexed keywords

7 CHLORO 1,3 DIHYDRO 5 (2 PYRROLYL) 2H 1,4 BENZODIAZEPIN 2 ONE; BENZODIAZEPINE DERIVATIVE; LUCIFERASE; TRANSACTIVATOR PROTEIN; [7 CHLORO 5 (1H PYRROL 2 YL) 3H BENZO[E][1,4]DIAZEPIN 2 YL]METHYLAMINE;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRANSACTIVATION; VIRUS INHIBITION; VIRUS REPLICATION;

EID: 0029885550     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/0223-5234(96)85171-3     Document Type: Article

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