Errors associated with experimental determinations of enzyme flux control coefficients

Journal of Theoretical Biology

Volumn 179, Issue 3, 1996, Pages 191-197

  Pettersson, Gösta ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b CHEMICAL CENTER   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CONCENTRATION RESPONSE; ELASTICITY; ENZYME KINETICS; MATHEMATICAL MODEL; METABOLIC REGULATION; PRIORITY JOURNAL; REGRESSION ANALYSIS;

EID: 0029885515     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.1996.0060     Document Type: Article

References (16)

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3. DELGADO, J. & LIAO, J. C. (1992b). Metabolic control analysis using transient metabolite concentrations. Biochem. J. 285, 965-972.
4. FELL, D. A. (1992). Metabolic control analysis: a survey of its theoretical and experimental development. Biochem. J. 286, 313-330.
5. GALAZZO, J. L. & BAILEY, J. E. (1990). Fermentation pathway kinetics and metabolic flux control in suspended and immobilized Saccharomyces cerevisiae. Enzyme Microb. Technol. 12, 162-172.
6. GELLERICH, F. N., KUNZ, W. S. & BOHNENSACK, R. (1990). Estimation of flux control coefficients from inhibitor titrations by non-linear regression. FEBS Lett. 274, 167-170.
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8. GIERSCH, C. (1994b). Determining elasticities from multiple measurements of flux rates and metabolite concentrations: application of the multiple modulation method to a reconstituted pathway. Eur. J. Biochem. 227, 194-201.
9. HEINRICH, R. & RAPOPORT, T. A. (1974). A linear steady-state treatment of enzymatic chains. Eur. J. Biochem. 42, 89-95.
10. KACSER, H. & BURNS, J. A. (1973). The control of flux. Symp. Soc. Exp. Biol. 27, 65-104.
11. KRUCKEBERG, A. L., NEUHAUS, H. E., FEIL, R., GOTTLIEB, L. D. & STITT, M. (1989). Decreased-activity mutants of phosphoglucose isomerase in the cytosol and chloroplast of Clarkia xantiana. Biochem. J. 261, 457-467.
12. PETTERSSON, G. & RYDE-PETTERSSON, U. (1988). A mathematical model of the Calvin photosynthesis cycle. Eur. J. Biochem. 175, 661-672.
13. PETTERSSON, G. (1995). Error associated with experimental determinations of flux control coefficients in the Calvin cycle. Biochim. Biophys. Acta (in press).
14. SMALL, J. R. (1993). Flux control coefficients determined by inhibitor titration: the design and analysis of experiments to minimize errors. Biochem. J. 296, 423-433.
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