Effects of phencyclidine metabolites on serotonin uptake in rat brain

Neuroscience Letters

Volumn 209, Issue 3, 1996, Pages 153-156

  Hori, Takafumi ^a   Suzuki, Toshihito ^a   Baba, Atsuomi ^a   Abe, Shuzo ^a   Yamamoto, Toshifumi ^b   Moroji, Takashi ^c   Shiraishi, Hiroyasu ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c Sapporo Hanazono Hospital   (Japan)

Author keywords

4 Phenyl 4 (1 piperidinyl)cyclohexanol (4 PPC); Phencyclidine (PCP); Rat brain; Serotonin uptake

Indexed keywords

3 PHENYL 3 PIPERIDINOCYCLOHEXANOL; 4 PHENYL 4 PIPERIDINOCYCLOHEXANOL; DRUG METABOLITE; KETANSERIN; PAROXETINE; PHENCYCLIDINE; SEROTONIN 1 RECEPTOR; SEROTONIN 2 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SEROTONIN UPTAKE;

EID: 0029885435     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)11617-7     Document Type: Article

References (21)

1. Baba, A., Yamamoto, T., Kawai, N., Yamamoto, H., Suzuki, T. and Moroji, T., Behavioral effects of phencyclidine and its major metabolite, (trans)4-phenyl-4-(1-piperidinyl)cyclohexanol, in mice, Behav. Brain. Res., 65 (1994) 75-81.
2. 3H]dopamine uptake in the rat brain, Neurosci. Lett., 182 (1994) 119-121.
3. Bleich, A., Brown, S.L., Kahn, R. and van Praag, H.M., The role of serotonin in schizophrenia, Schizophrenia Bull., 14 (1988) 297-315.
4. Carroll, F.I., Brine, G.A., Boldt, K.G., Cone, E.J., Yousefnejad, D., Vaupel, D.B. and Buchwald, W.F., Phencyclidine metabolism: resolution, structure, and biological activity of the isomers of the hydroxy metabolite, 4-phenyl-4-(1-piperidinyl)cyclohexanol, J. Med. Chem., 24 (1981) 1047-1052.
5. Cone, E.J., Vaupel, D.B. and Yosefnejad, D., Metabolism of phencyclidine (PCP) and relative potencies of two monohydroxylated metabolites, Fed. Proc. Fed. Am. Soc. Exp. Biol., 39 (1980) 302.
6. Cook, C.E., Perez, R.M., Jeffcoat, A.R. and Brine, D.R., Phencyclidine disposition in humans after small doses of radiolabeled drug, Fed. Proc., 42 (1983) 2566-2569.
7. Giannini, A.J., Loiselle, R.H., Giannini, M.C. and Price, W.A., Phencyclidine and the dissociatives, Psychiatry Med., 3 (1987) 197-217.
8. Gole, J.D., Pirat, J.L. and Domino, E.F., New aspects of phencyclidine (PCP) metabolism. In E.F. Domino and J.M. Kamenka (Eds.), Sigma and Phencyclidine-Like Compounds as Molecular Probes in Biology, NPP Books, MI, 1988, pp. 625-641.
9. 3H]paroxetine binding to rat cortical membranes, Eur. J. Pharmacol., 118 (1985) 107-114.
10. Javitt, D.C. and Zukin, S.R., Recent advances in the phencyclidine model of schizophrenia, Am. J. Psychiatry, 148 (1991) 1301-1308.
11. Johnson, K.M., Neurochemistry and neurophysiology of phencyclidine. In H.Y. Meltzer (Ed.), Psychopharmacology, Raven Press, New York, 1987 pp. 1581-1588.
12. Martin, D.C., Introna, R.P. and Aronstam, R.S., Inhibition of neuronal 5-HT uptake by ketamine, but not halothane, involves disruption of substrate recognition by the transporter, Neurosci. Lett., 112 (1990) 99-103.
13. Martin, J.R., Berman, M.H., Krewsun, I. and Small, S.F., Phencyclidine-induced stereotyped behavior and serotonergic syndrome in rat, Life Sci., 24 (1979) 1699-1704.
14. Misra, A.L., Pontani, R.B. and Bartolomeo, J. Persistence of phencyclidine (PCP) and metabolites in brain and adipose tissue and implications for long-lasting behavioural effects, Res. Commun. Chem. Pathol. Pharmacol., 24 (1979) 431-445.
15. 1 receptor, Res. Commun. Subst. Abuse, 5 (1984) 81-87.
16. Nabeshima, T., Yamaguchi, K., Hiramatsu, M., Amano, M., Kurukawa, H. and Kameyama, T., Serotonergic involvement in phencyclidine-induced behaviors, Pharmacol. Biochem. Behav., 21 (1984) 401-408.
17. Nelson, D.L., Herbet, A., Bourgoin, S., Glowinski, J. and Hamon, M., Characteristics of central 5-HT receptors and their adaptive changes following intracerebral 5,7-dihydroxytryptamine administration in the rat, Mol. Pharmacol., 14 (1978) 983-995.
18. Pazos, A., Hoyer, D. and Palacios, J.M., Mesulergine, a selective serotonin-2 ligand in the rat cortex, does not label these receptors in porcine and human cortex: evidence for species differences in brain serotonin-2 receptors, Eur. J. Pharmacol., 106 (1984) 531.
19. Rainey, Jr., J.M. and Crowder, M.K., Prolonged psychosis to phencyclidine: report of three cases, Am. J. Psychiatry, 132 (1975) 1076-1078.
20. 3H]serotonin uptake in synaptosomal preparations from rat brain, Biochem. Pharmacol., 26 (1977) 1435-1439.
21. Tonge, S.R. and Leonard, B.E., The effects of some hallucinogenic drugs upon the metabolism of 5-hydroxy-tryptamine in the brain, Life Sci., 8 (1969) 805-814.