Effects of food and antacid on the pharmacokinetics of single doses of mycophenolate mofetil in rheumatoid arthritis patients

British Journal of Clinical Pharmacology

Volumn 41, Issue 6, 1996, Pages 513-516

  Bullingham, R ^a   Shah, J ^a,c   Goldblum, R ^a,d   Schiff, M ^b  

^a Roche Global Development Palo Alto   (United States)

^b Denver Arthritis Clinic PC   (United States)

^c ALZA CORPORATION   (United States)

^d Neurobiological Technologies Inc   (United States)

Author keywords

antacid; food; interactions; mycophenolate mofetil; pharmacokinetics

Indexed keywords

ALUMINUM MAGNESIUM HYDROXIDE; DRUG METABOLITE; GLUCURONIDE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

AGED; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET RESTRICTION; DRUG BLOOD LEVEL; DRUG GLUCURONIDATION; FEMALE; FOOD DRUG INTERACTION; HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; STOMACH EMPTYING;

EID: 0029885182     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1996.03636.x     Document Type: Article

References (8)

1. Lee WA, Gu L, Miksztal AR, Chu N, Leung K, Nelson PH. Bioavailability improvement of mycophenolic acid through amino ester derivatization. Pharm Res 1990; 7: 161-166.
2. Eugui EM, Almquist S, Muller CD, Allison A. Lymphocyte selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depletion. Scand J Immunol 1991; 33: 161-173.
3. Bullingham RES, Nicholls A, Hale M. Pharmacokinetics of mycophenolate mofetil (RS61443): a short review. Transplantation Proc 1996; 28: 935-939.
4. Melander A. Influence of food on the bioavailability of drugs. Clin Pharmacokinet 1978; 3: 337-351.
5. Tsina I, Chu F, Hama K, Kaloostian M, Tam Y-L, Tarnowski T, Wong B. Manual and automated (robotic) HPLC methods for the determination of mycophenolic acid and its glucuronide conjugate in human plasma. J Chromatog B: Biomed Appl 1996; 675: 119-129.
6. Schuirman DJ. A comparison of the two-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. J Pharmacokinet Biopharm 1987; 15: 657-680.
7. Herman RJ, Due Van Pham J, Szakacs CBN. Disposition of lorazepam in human beings: enterohepatic recirculation and first-pass effect. Clin Pharmacol Ther 1989; 46: 18-25.
8. Herman RJ, Chaudhary A, Szakacs CB. Disposition of lorazepam in Gilbert's Syndrome: effects of fasting, feeding, and enterohepatic circulation. J Clin Pharmacol 1994; 34: 978-984.