Pancreatic secretion stimulated by CCK is not mediated by capsaicin-sensitive vagal afferent pathway in awake rats

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 270, Issue 5 33-5, 1996, Pages

  Guan, Difu ^a   Phillips, William T ^a   Green, Gary M ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Exocrine pancreas; Negative feedback regulation

Indexed keywords

CAPSAICIN; CHOLECYSTOKININ;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FOOD INTAKE; MALE; NEGATIVE FEEDBACK; NONHUMAN; PANCREAS SECRETION; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SENSORY NERVE; STOMACH EMPTYING; VAGUS NERVE; WAKEFULNESS;

AFFERENT PATHWAYS; ANIMALS; BILIOPANCREATIC DIVERSION; CAPSAICIN; CASEINS; CHOLECYSTOKININ; DEOXYGLUCOSE; DUODENUM; EATING; GASTRIC EMPTYING; INJECTIONS; MALE; PANCREAS; RATS; RATS, WISTAR; SINCALIDE; VAGUS NERVE;

EID: 0029884609     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1996.270.5.g881     Document Type: Article

References (29)

1. Chariot, J., J. de la Tour, P. Anglade, C. Roze, J. Chariot, J. De la Tour, C. Vaille, and C. Roze. Cholinergic mechanisms in the pancreas after extrinsic denervation in the rat: comparative effects of pirenzepine and atropine on pancreatic secretion in conscious rats. Am. J. Physiol. 252 (Gastrointest. Liver Physiol. 15): G755-G761, 1987.
2. Chariot, J., J. de la Tour, C. Vaille, and C. Roze. Comparative effects of pirenzepine and atropine on pancreatic secretion in conscious rats. Arch. Int. Pharmacodyn. 285: 158-165, 1987.
3. Chariot, J., C. Nagain, F. Hugonet, A. Tsocas, and C. Roze. Control of interdigestive and intraduodenal meal-stimulated pancreatic secretion in rats. Am. J. Physiol. 259 (Gastrointest. Liver Physiol. 22): G198-G204, 1990.
4. Dembinski, A., Z. Warzecha, P. Ceranowicz, and S. J. Konturek. Capsaicin-sensitive afferent neurons and nitric oxide (NO) affect pancreatic integrity in caerulein-induced pancreatitis (Abstract). Gut 37, Suppl. 2: A49, 1995.
5. Diamond, J. M. How to be physiological. Nature Lond. 376: 117-118, 1995.
6. Elashoff, J. D., J. H. Meyer, and T. J. Reedy. Analysis of gastric emptying data. Gastroenterology 83: 1306-1312, 1982.
7. Green, G. M., and K. Miyasaka. Rat pancreatic response to intestinal infusion of intact and hydrolyzed protein. Am. J. Physiol. 245 (Gastrointest. Liver Physiol. 8): G394-G398, 1983.
8. Green, G. M., and E. S. Nasset. Role of dietary protein in rat pancreatic enzyme secretory response to a meal. J. Nutr. 113: 2245-2252, 1983.
9. Guan, D., H. Ohta, T. Tawil, A. W. Spannagel, R. A. Liddle, and G. M. Green. Lack of cholinergic control in feedback regulation of pancreatic secretion in the rat. Gastroenterology 98: 437-443, 1990.
10. Holzer, H. H., C. M. Turkelson, T. E. Solomon, and H. E. Raybould. Intestinal lipid inhibits gastric emptying via CCK and a vagal capsaicin-sensitive afferent pathway in rats. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G625-G629, 1994.
11. Levan, V. H., and G. M. Green. Effect of atropine on rat pancreatic secretory response to trypsin inhibitors and protein. Am. J. Physiol. 251 (Gastrointest. Liver Physiol. 14): G64-G69, 1986.
12. Li, Y., and C. Owyang. Endogenous cholecystokinin stimulates pancreatic enzyme secretion via vagal afferent pathway in rats. Gastroenterology 107: 525-531, 1994.
13. Li, Y., and C. Owyang. Vagal afferent pathway mediates physiological action of cholecystokinin on pancreatic enzyme secretion. J. Clin. Invest. 92: 418-424, 1993.
14. Liddle, R. A., I. D. Goldfine, and J. A. Williams. Bioassay of plasma cholecystokinin in rats: effects of food, trypsin inhibitor, and alcohol. Gastroenterology 87: 542-549, 1984.
15. Louie, D. S., D. May, P. Miller, and C. Owyang. Cholecystokinin mediates feedback regulation of pancreatic enzyme secretion in rats. Am. J. Physiol. 250 (Gastrointest. Liver Physiol. 13): G252-G259, 1986.
16. Masuda, M., H. Tomita, K. Okubo, and K. Miyasaka. Vagal efferent nerve-dependent inhibitory action of pancreatic polypeptide and peptide YY in conscious rats: comparison with somatostatin. J. Autonom. Nerv. Syst., 50: 131-138, 1994.
17. Nakano, I., T. Tawil, A. W. Spannagel, R. A. Liddle, and G. M. Green. Atropine enhances food-stimulated CCK secretion in the rat. Pancreas 5: 621-625, 1990.
18. O'Rourke, M. F., R. D. Reidelberger, and T. E. Solomon. Effect of CCK antagonist L-364718 on meal-induced pancreatic secretion in rats. Am. J. Physiol. 258 (Gastrointest. Liver Physiol. 21): G179-G184, 1990.
19. O'Rourke, M. F., R. D. Reidelberger, and T. E. Solomon. Effects of atropine on pancreatic response to bethanechol, cholecystokinin, and food intake in rats. Am. J. Physiol. 261 (Gastrointest. Liver Physiol. 24): G735-G741, 1991.
20. Pap, A., and H. Sarles. Effect of atropine on pancreatic secretion in conscious rats. Digestion 33: 17-25, 1986.
21. Plusczyk, T., M. Bauer, I. Marzi, G. Harbauer, and G. Feifel. Comparative effects of secretin (SEC) and cholecystokinin-octapeptide (CCK-8) on pancreatic microcirculation. Dig. Dis. Sci. 40: 1199-1206, 1995.
22. Raybould, H. E., and Y. Taché. Cholecystokinin inhibits gastric motility and emptying via a capsaicin-sensitive vagal pathway in rats. Am. J. Physiol. 255 (Gastrointest. Liver Physiol. 18): G242-G246, 1988.
23. Reidelberger, R. D., G. Varga, R. M. Liehr, D. A. Castellanos, G. L. Rosenquist, H. C. Wong, and J. H. Walsh. Cholecystokinin suppresses food intake by a nonendocrine mech-anism in rats. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R901-R908, 1994.
24. Reidelberger, R. D., G. Varga, and T. E. Solomon. Effects of selective cholecystokinin antagonists L-364,718 and L-365,260 on food intake in rats. Peptides 12: 1215-1221, 1991.
25. Ritter, R. C., and E. H. South. Capsaicin application to central or peripheral vagal fibers attenuates CCK satiety. Peptides 9: 601-612, 1988.
26. Roze, C., J. Chariot, J. de La Tour, M. Souchard, C. Vaille, and C. Debray. Methadone blockade of 2-deoxyglucose-induced pancreatic secretion in the rat. Gastroenterology 74: 215-220, 1978.
27. Spannagel, A. W., I. Nakano, T. Tawil, W. Y. Chey, R. A. Liddle, and G. M. Green. Adaptation to fat markedly increases the pancreatic secretory response to intraduodenal fat in the rat. Am. J. Physiol. 270 (Gastrointest. Liver Physiol. 33): G128-G135, 1996.
28. Taguchi, S., G. M. Green, I. Nakano, and Y. Hatta. Inhibitory effects of the cholecystokinin antagonist loxiglumide on pancreatic exocrine secretion and pancreatic growth in conscious rats. Int. J. Pancreatol. 11: 67-73, 1992.
29. Ugolev, A. M. Membrane transport and hydrolytic enzymes under physiological vs. acute experimental conditions. News Physiol. Sci. 2: 186-190, 1987.