Ouabain is a potent inhibitor of aldosterone secretion and angiotensin action in the human adrenal

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 6, 1996, Pages 2335-2337

  Antonipillai, Indra ^a,b   Schick, Kathleen ^a   Horton, Richard ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b LAC USC MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ANGIOTENSIN; OUABAIN; POTASSIUM; TETRACOSACTIDE;

ALDOSTERONE RELEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ZONA GLOMERULOSA;

ADRENAL GLANDS; ADRENOCORTICOTROPIC HORMONE; ALDOSTERONE; ALDOSTERONE ANTAGONISTS; ANGIOTENSIN II; ANIMALS; HUMANS; MALE; OUABAIN; POTASSIUM; RATS; RATS, SPRAGUE-DAWLEY; ZONA GLOMERULOSA;

ANIMALIA; DIGITALIS; STROPHANTHUS GRATUS;

EID: 0029884443     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.6.2335     Document Type: Article

References (29)

1. Sweadner KJ. 1988 Isoenzymes of the Na,K-ATPase. Biochim Biophys Acta. 988:185-220.
2. Dumbacher JP, Beehler BM, Spande TF, Garraffo HM, Daly JW. 1992 Homobatrachotoxin in the genus Pitohui: chemical defense in birds. Science. 258:799-801.
3. Lichtstein D, Gati I, Babilla T, Haver E, Katz U. 1991 Effect of salt acclimation on digitalis-like compounds in the toad. Biochim Biophys Acta. 1073:65-68.
4. Hamlyn JM, Blaustein MP, Bova S, et al. 1991 Identification and characterization of a ouabain-like compound from human plasma. Proc Natl Acad Sci USA. 88:6259-6263.
5. Ferrandi M, Minotti E, Salardi S, Florio M, Bianchi G, Ferrari P. 1992 Ouabain-like factor in Milan hypertensive rats. Am J Physiol. 263:F739-F748.
6. Boulanger BR, Lilly MP, Hamlyn JM, Laredo J, Shartleff D, Gann DS. 1993 Ouabain is secreted by the adrenal gland in awake dogs. Am J Physiol. 264: E413-E419.
7. Ludens JH, Clark MA, Robinson FG, Ducharme DW. 1992 Rat adrenal cortex is a source of a circulating ouabain-like compound. Hypertension. 19:721-724.
8. Doris PA, Jenkins LA, Stocco DM. 1994 Is ouabain an authentic endogenous mammalian substance derived from the adrenal? Hypertension. 23:632-638.
9. Lewis LK, Yandle TG, Lewis JG, et al. 1994 Ouabain is not detectable in human plasma. Hypertension. 24:549-555.
10. Gomez-Sanchez EP, Foeckiney MF, Sellers D, Blankenship MS, Gomez-Sanchez CE. 1994 Is the circulating ouabain-like compound ouabain? Am J Hypertens. 7:647-650.
11. Natarajan R, Nadler J. 1992 Angiotensin II-induced aldosterone synthesis is potentiated by epidermal growth factor. Endocrinology. 128:2285-2290.
12. Ito T, Woo J, Haning R, Horton R. 1972 A radioimmunoassay for aldosterone in human peripheral plasma. Including a comparison of alternate techniques. J Clin Endocrinol Metab. 34:106.
13. Gomoll AW, Sherrod TR. 1964 Influence of acetylstrophanthidin on aldosterone secretion in the intact anesthetized dog. Arch Int Pharmacodyn Ther. 150:469-480.
14. Cushman P. 1969 Inhibition of aldosterone secretion by ouabain in dog adrenal cortical tissue. Endocrinology. 84:808-813.
15. Boyd J, Mulrow PJ, Palmore WP, Silvo P. 1973 Importance of potassium in the regulation of aldosterone production. Circ Res. 32(Suppl 1):1.
16. Blaine EH, Coghlan JP, Denton DA, Scoggins BA. 1974 In vivo effects of ouabain on aldosterone, corticosterone and cortisol secretion in conscious sheep. Endocrinology. 94:1304-1309.
17. Foster R, Lobo MV, Marusic ET. 1979 Studies of relationship between angiotensin II and potassium ions on aldosterone release. Am J Physiol. 237: E363-E368.
18. + and ouabain. Am J Physiol. 241:E42-E48.
19. Braley LM, Williams GH. 1978 The effects of ouabain on steroid production by rat adrenal cells stimulated by angiotensin II, alpha 1-24 adrenocorticotropin and potassium. Endocrinology. 103:1997-2005.
20. Elliott ME, Hadjokas NE, Goodfriend TL. 1986 Effects of ouabain and potassium on protein synthesis and angiotensin-stimulated aldosterone synthesis in bovine adrenal glomerulosa cells. Endocrinology. 118:1469-1475.
21. Schiebinger RJ, Cragoe Jr EJ. 1993 Ouabain, a stimulator of atrial natriuretic peptide secretion and its mechanism of action. Circ Res. 72:1035-1043.
22. Laredo J, Hamilton BP, Hamlyn J. 1994 Ouabain is secreted by bovine adrenocortical cells. Endocrinology. 135:794-798.
23. Covit AB, Schaer GL, Sealey JF, Laragh JH, Cody RJ. 1983 Suppression of the renin-angiotensin system by intravenous digoxin in chronic congestive heart failure. Am J Med. 75:445-447.
24. Churchill PC. 1979 Possible mechanism of the inhibitory effect of ouabain on renin secretion from rat renal cortical slices. Am J Physiol. 294:123-134.
25. Cruz-Soto M, Benabe JE, Lopez-Novoa JM, Maldonado M. 1984 Na,K-AT-Pase inhibitors and renin release: relationship to calcium. Am J Physiol. 247: F650-F655.
26. Antonipillai I, Schick K, Horton R. 1994 Ouabain inhibits angiotensin action on renin and aldosterone. Clin Res. 42:44A (Abstract).
27. ++ stores and cell responsiveness. Am J Physiol. 264:C1367-C1387.
28. ++ ionic currents in glomerulosa cells from human adrenal glands. Endocrinology. 134:2589-2598.
29. + balance in sheep. Proc Soc Exp Biol Med. 150:257-261.