Mathematical modeling of proteinase A overproduction by Saccharomyces cerevisiae

Annals of the New York Academy of Sciences

Volumn 782, Issue , 1996, Pages 350-362

  Grøn, Susanne ^a   Jochumsen, Kirsten Væver ^a   Biedermann, Kirsten ^a   Emborg, Claus ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE;

CONFERENCE PAPER; FERMENTATION; GENETIC RECOMBINATION; KINETICS; MATHEMATICAL MODEL; NONHUMAN; PLASMID; PROMOTER REGION; PROTEIN SYNTHESIS; SACCHAROMYCES CEREVISIAE; STEADY STATE; TRANSCRIPTION REGULATION;

SACCHAROMYCES CEREVISIAE;

EID: 0029884118     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb40574.x     Document Type: Article

References (29)

1. GRØN, S., C. EMBORG & K. BIEDERMANN. 1995. Enzyme production in a cell recycle fermentation system evaluated by computer simulations. Bioprocess Eng. 13: 59-68.
2. STRUDSHOLM, K., J. DAMGAARD & C. EMBORG. 1992. Application of statistical experimental designs in computer simulations of runaway fermentations. Bioprocess Eng. 8: 113-119.
3. DA SILVA, N. A. & J. E. BAILEY. 1986. Theoretical growth yield estimates for recombinant cells. Biotechnol. Bioeng. 28: 741-746.
4. HJORTSØ, M. A. & J. E. BAILEY. 1984. Plasmid stability in budding yeast population: Dynamic following a shift to non-selective medium. Biotechnol. Bioeng. 26: 814-819.
5. SRIENC, F., J. L. CAMBELL & J. E. BAILEY. 1986. Analysis of unstable recombinant Saccharomyces cerevisiae population growth in selective medium. Biotechnol. Bioeng. 28: 996-1006.
6. SARDONINI, C. A. & D. DIBIASIO. 1987. A model for growth of Saccharomyces cerevisiae containing a recombinant plasmid in selective media. Biotechnol. Bioeng. 29: 469-475.
7. +] in non-selective and selective media. Biotechnol. Bioeng. 32: 733-740.
8. WITTRUP, K. D. & J. E. BAILEY. 1988. A segregated model of recombinant multicopy plasmid propagation. Biotechnol. Bioeng. 31: 304-310.
9. WITTRUP, K. D., J. E. BAILEY, B. RATZKIN & A. PATEL. 1990. Propagation of an ampliflable recombinant plasmid in Saccharomyces cerevisiae: Flow cytometry studies and segregated modelling. Biotechnol. Bioeng. 53: 565-577.
10. SHI, Y., D. D. Y. RYU & W.-K. YAUN. 1993. Effects of oxygen and ethanol on recombinant yeast fermentation for hepatitis B virus surface antigen production: Modelling and simulation studies. Biotechnol. Bioeng. 41: 55-66.
11. PATKAR, A. & J.-H. SEO. 1992. Fermentation kinetics of recombinant yeast in batch and fed-batch cultures. Biotechnol. Bioeng. 40: 103-109.
12. COPPELLA, S. J. & P. DHURJATI. 1990. A mathematical description of recombinant yeast. Biotechnol. Bioeng. 35: 356-374.
13. HARDJITO, L., P. F. GREENFIELD & P. L. LEE. 1992. A model for β-galactosidase production with a recombinant yeast Saccharomyces cerevisiae in fed-batch culture. Biotechnol. Prog. 8: 298-306.
14. GRØN, S., C. MORCEL, C. EMBORG & K. BIEDERMANN. 1995. Cell recycling studies for α-amylase production by Bacillus amyloliquefaciens. Bioprocess Eng. 14: 23-32.
15. JONES, E. W. 1991. Three proteolytic systems in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 266: 7963-7966.
16. VAN DEN HAZEL, H. B., M. C. KIELLAND-BRANDT & J. R. WINTHER. 1992. Autoactivation of proteinase A initiates activation of yeast vacuolar zymogens. Eur. J. Biochem. 207: 277-283.
17. ROTHMAN, J. H., C. P. HUNTER, L. A. VALLS & T. H. STEVENS. 1986. Overproduction-induced mislocalization of a yeast vacuolar protein allows isolation of its structural gene. Proc. Natl. Acad. Sci. 83: 3248-3252.
18. BATT, B. C. & D. S. KOMPALA. 1989. A structured kinetic modelling framework for the dynamics of hybridoma growth and monoclonal antibody production in the continuous suspension cultures. Biotechnol. Bioeng. 3-4: 515-531.
19. FLETCHER, R. 1971. A modified Marquardt subroutine for non-linear least squares. Harwell Rep. AERE R.6799.
20. VILLADSEN, J. & M. MICHELSEN. 1978. Solutions of Differential Equations: Models by Polynomial Approximation. Prentice-Hall Inc. Englewood Cliffs, NJ.
21. POSTMA, E. Regulation of sugar transport in yeast; a continuous culture study. Ph.D. thesis, Technical University of Delft. Delft, the Netherlands.
22. BENTHIN, S., J. NIELSEN & J. VILLADSEN. 1992. Anomeric specifity of glucose uptake systems in Lactococcus cremoris, Escherichia coli and Saccharomyces cerevisiae: Mechanism, kinetics and implications. Biotechnol. Bioeng. 40: 137-146.
23. BARFORD, J. P. 1990. A general model for aerobic yeast growth: Continuous culture. Biotechnol. Bioeng. 35: 921-927.
24. JOCHUMSEN, K. V. 1995. Production of proteinase A by Saccharomyces cerevisiae. Ph.D. Thesis, Department of Biotechnology, The Technical University of Denmark, Lyngby, Denmark.
25. FRANDSEN, S. J. 1993. Dynamics of Saccharomyces cerevisiae in continuous culture. Ph.D. Thesis, Department of Biotechnology, The Technical University of Denmark, Lyngby, Denmark.
26. HANSEN, H. A., N. M. MADSEN & C. EMBORG. 1993. An evaluation of fed-batch cultivation methods for mammalian cells based on model simulations. Bioprocess Eng. 9: 205-213.
27. GRØN, S., K. BIEDERMANN & C. EMBORG. 1994. Production of proteinase A by Saccharomyces cerevisiae in a cell recycle fermentation system: Experiments and simulations. To be submitted.
28. PARK, S. Y., S. SHIBA, S. LIJIMA, T. KOBAYASHI & F. HISHINUMA. 1993. Comparison of three different promoter systems for secretory α-amylase production in fed-batch cultures of recombinant Saccharomyces cerevisiae. Biotechnol. Bioeng. 41: 854-861.
29. SHIBA, S., Y. NISHIDA, Y. S. PARK, S. LIJIMA & T. KOBAYASHI. 1994. Improvement of cloned α-amylase gene expression in fed-batch culture of recombinant Saccharomyces cerevisiae by regulating both glucose and ethanol concentrations using fuzzy controller. Biotechnol. Bioeng. 44: 1055-1063.