Differential effects of acute hypertriglyceridemia on insulin action and insulin receptor autophosphorylation

American Journal of Physiology

Volumn 270, Issue 3 PART 1, 1996, Pages

  Gumbiner, Barry ^a,b,c   Mucha, Jeffrey F ^a,b,c   Lindstrom, Jennifer E ^a,b,c   Rekhi, Ishali ^a,b,c   Livingston, James N ^a,b,c  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b BAYER CORPORATION   (United States)

^c Monroe Community Hospital   (United States)

Author keywords

Calorimetry; Insulin resistance; Insulin signal transduction

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; INSULIN RECEPTOR; TRIACYLGLYCEROL;

ARTICLE; AUTOPHOSPHORYLATION; CALORIMETRY; CONTROLLED STUDY; FEMALE; GLUCOSE METABOLISM; GLUCOSE OXIDATION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; MALE; MUSCLE BIOPSY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

ADULT; BIOPSY; BLOOD GLUCOSE; BLOOD UREA NITROGEN; CALORIMETRY; EMULSIONS; FATTY ACIDS, NONESTERIFIED; FEMALE; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPERINSULINISM; HYPERTRIGLYCERIDEMIA; INFUSIONS, INTRAVENOUS; INSULIN; MALE; MUSCLE, SKELETAL; PHOSPHORYLATION; RECEPTOR, INSULIN; TRIGLYCERIDES;

EID: 0029883955     PISSN: 00029513     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.270.3.e424     Document Type: Article

References (36)

1. Arner, P., T. Pollare, H. Lithell, and J. N. Livingston. Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 30: 437-440, 1992.
2. Boden, G., F. Jadali, J. White, Y. Liang, M. Mozzoli, X. Chen, E. Coleman, and E. Smith. Effects of fat on insulin-stimulated carbohydrate metabolism in normal man. J. Clin. Invest. 88: 960-966, 1991.
3. Bonadonna, R. C., K. Zych, C. Boni, E. Ferrannini, and R. A. DeFronzo. Time dependence of the interaction between lipid and glucose in humans. Am. J. Physiol. 257 (Endocrinol. Metab. 20): E49-E56, 1989.
4. Burant, C. F., M. K. Treutelaar, and M. G. Guse. Tissue specific differences in the insulin receptor kinase activated in vitro and in vivo. Endocrinology 122: 427-437, 1988.
5. Cheatham, B., and C. R. Kahn. Insulin action and the insulin signaling network. Endocr. Rev. 16: 117-142, 1995.
6. Colberg, S. R., J.-A. Simoneau, F. L. Thaete, and D. E. Kelley. Skeletal muscle utilization of free fatty acids in women with visceral obesity. J. Clin. Invest. 95: 1846-1853, 1995.
7. DeFronzo, R.A., E. Jacot, E. Jequier, E. Maeder, J. Wahren, and J. P. Felber. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30: 1000-1007, 1981.
8. Dole, V. P., and H. Meinertz. Microdetermination of long-chain fatty acids in plasma and tissues. J. Biol. Chem. 235: 2595-2599, 1960.
9. Ferrannini, E. The theoretical bases of indirect calorimetry: a review. Metab. Clin. Exp. 37: 287-301, 1988.
10. Ferrannini, E., E. J. Barrett, S. Bevilacqua, and R. A. DeFronzo. Effect of fatty acids on glucose production and utilization in man. J. Clin. Invest. 72: 1737-1747, 1983.
11. Freidenberg, G. R., S. L. Suter, R. R. Henry, D. Reichart, and J. M. Olefsky. In vivo stimulation of the insulin receptor kinase in human skeletal muscle: correlation with insulin-stimulated glucose disposal during euglycemic clamp studies. J. Clin. Invest. 87: 2222-2229, 1991.
12. Ginsberg, B. H., T. J. Brown, I. Simon, and A. A. Spector. Effect of the membrane lipid environment on the properties of insulin receptors. Diabetes 30: 773-780, 1981.
13. Groop, L. C., C. Saloranta, M. Shank, R. C. Bonadonna, E. Ferrannini, and R. A. DeFronzo. The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 72: 96-107, 1991.
14. Gumbiner, B., A. W. Thorburn, T. M. Ditzler, F. Bulacan, and R. R. Henry. Role of impaired intracellular glucose metabolism in the insulin resistance of aging. Metab. Clin. Exp. 41: 1115-1121, 1992.
15. Hubert, P., C. Bruneau-Wack, G. Cremel, Y. LeMarchand-Brustel, and C. Staedel. 1991. Lipid-induced insulin resistance in cultured hepatoma cells is associated with a decreased insulin receptor tyrosine kinase activity. Cell Regul. 2: 65-72, 1991.
16. Hunnicut, J., R. Hardy, J. Willifor, and J. McDonald. Saturated fatty acid-induced insulin resistance in rat adipocytes. Diabetes 43: 540-545, 1994.
17. Kelley, D. E., M. Mokan, J.-A. Simoneau, and L. J. Mandarine. Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J. Clin. Invest. 92: 91-98, 1993.
18. Kelley, D. E., and J. A. Sinioneau. Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus. J. Clin. Invest. 94: 2349-2356, 1994.
19. Kriauciunas, K. M., F. Grigorescu, and C. R. Kahn. Effects of heparin on insulin binding and biological activity. Diabetes 36: 163-168, 1987.
20. Liu, R., J. Zhu, N. Jospe, R. Furlanetto, W. Bastian, and J. N. Livingston. Deletion of lysine 121 creates a temperature-sensitive alteration in insulin binding in the insulin receptor. J. Biol. Chem. 270: 476-482, 1995.
21. Maegawa, H., Y. Shigeta, K. Egawa, and M. Kobayashi. Impaired autophosphorylation of insulin receptors from abdominal skeletal muscles in nonobese subjects with NIDDM. Diabetes 40:815-819, 1991.
22. McGarry, J. D. What if Minkowski had been ageusic? An alternative angle on diabetes. Science Wash. DC 258: 766-770, 1992.
23. McKane, W. R., A. B. Stevens, R. Woods, W. J. Andrews, R. W. Henry, and P. M. Bell. The assessment of hepatic and peripheral insulin sensitivity in hypertriglyceridemia. Melab. Clin. Exp. 39: 1240-1245, 1990.
24. Nagy, K., J. Levy, and G. Grunberger. High-fat feeding induces tissue-specific alteration in proportion of activated insulin receptors in rats. Acta Endocrinol. 3: 361-368, 1990.
25. Nolan, J., G. Freidenberg, R. Henry, D. Reichart, and J. Olefsky. Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity. J. Clin. Endocrinol. Mctab. 78: 471-477, 1994.
26. Nyomba, B. L., B. A. Swinburn, V. M. Ossowski, V. L. Boyce, C. Bogardus, and D. M. Mott. Insulin-sensitive tyrosine kinase activity changes in parallel with plasma insulin and glucose concentrations in humans. J. Clin. Endocrinol. Metab. 72: 1212-1219, 1991.
27. O'Meara, N. M., G. F. Lewis, V. G. Cabana, P. H. Iverius, G. S. Getz, and K. S. Polonsky. Role of basal triglycéride and high density lipoprotein in determination of postprandial lipid and lipoprotein responses. J. Clin. Endocrinol. Metab. 75: 465-471, 1992.
28. Rändle, P. J., C. N. Haies, P. B. Garland, and E. A. Newsholme. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet i: 785-789, 1963.
29. Reaven, G. M. Banting Lecture 1988. Role of insulin resistance in human disease. Diabetes 37: 1595-1607, 1988.
30. Svedberg, J., P. Bjorntorp, U. Smith, and P. Lonnroth. Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes. Diabetes 39: 570-574, 1990.
31. Svedberg, J., P. Bjorntorp, U. Smith, and P. Lonnroth. Effect of free fatty acids on insulin receptor binding and tyrosine kinase activity in hepatocytes isolated from lean and obese rats. Diabetes 41: 294-298, 1992.
32. Thiebaud, D., R. A. DeFronzo, E. Jacot, A. Golay, K. Acheson, E. Maeder, E. Jequier, and J.-P. Felber. Effect of long chain triglycéride infusion on glucose metabolism in man. Metab. Clin. Exp. 31: 1128-1136, 1982.
33. Walker, M., G. R. Fulcher, C. F. Sum, H. Orskov, and K. G. M. M. Alberti. Effect of glycemia and nonesterified fatty acids on forearm glucose uptake in normal humans. Am. J. Physiol. 261 (Endocrinol. Metab. 24): E304-E311, 1991.
34. Yki-Jarvinen, H., I. Puhakainen, and V. A. Koivisto. Effect of free fatty acids on glucose uptake and nonoxidative glycolysis across human forearm tissues in the basal state and during insulin stimulation. J. Clin. Endocrinol. Metab. 72: 1268-1277, 1991.
35. Yki-Jarvinen, H., and M.-R. Taskinen. Interrelationships among insulin's antilipolytic and glucoregulatory effects and plasma triglycérides in nondiabetic and diabetic patients with endogenous hypertriglyceridemia. Diabetes 37: 1271-1278, 1988.
36. Zuniga-Guarjardo, S., G. Steiner, S. Shumak, and B. Zinman. Insulin resistance and action in hypertriglyceridemia. Diabetes Res. Clin. Prac. 14: 55-62, 1991.