In vitro immunoneutralization of a cleaved prolactin variant: Evidence for a local paracrine action of cleaved prolactin in the development of gonadotrophs and thyrotrophs in rat pituitary

Journal of Neuroendocrinology

Volumn 8, Issue 2, 1996, Pages 123-127

  Andries, Maria ^a,b   Jacobs, Greta F M ^a   Tilemans, Diane ^a   Denef, Carl ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b Laboratory of Cell Pharmacology   (Belgium)

Author keywords

Anterior pituitary; cIPRL; Gonadotrophs; Paracrine; Thyrotrophs

Indexed keywords

PROLACTIN;

ADENOHYPOPHYSIS; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; DNA SYNTHESIS; FEMALE; GONADOTROPIN SECRETING CELL; GROWTH REGULATION; HYPOPHYSIS CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN VARIANT; RAT; THYROTROPIN RELEASE;

ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; AUTORADIOGRAPHY; CELLS, CULTURED; FEMALE; GONADOTROPINS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; PITUITARY GLAND; PROLACTIN; RATS; THYMIDINE; THYROTROPIN;

EID: 0029883891     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2826.1996.tb00832.x     Document Type: Article

References (19)

1. Mittra I. (1980). A novel 'cleaved prolactin' in the rat pituitary: part I biosynthesis, characterization and regulatory control. Biochem Biophys Res Commun. 95: 1750-1759.
2. Sinha YN, Gilligan TA. (1984). A cleaved form of prolactin in the mouse pituitary gland: identification and comparison of in vitro synthesis and release in strains with high and low incidences of mammary tumors. Endocrinology. 114: 2046-2053.
3. Sinha YN, Gilligan TA, Lee DW, Hollingsworth D, Markoff E. (1985). Cleaved prolactin: evidence for its occurrence in human pituitary gland and plasma. J Clin Endocr Metab. 60: 239-243.
4. Andries M, Tilemans D, Denef C. (1992). Isolation of cleaved prolactin variants that stimulate DNA synthesis in specific cell types in rat pituitary cell aggregates in culture. Biochem J. 281: 393-400.
5. Vick RS, Wong VLY, Witorsch RJ. (1987). Biological, immunological and biochemical characterization of cleaved prolactin generated bu lactating mammary gland. Biochem Biophys Acta. 931: 196-204.
6. Clapp C. (1987) Analysis of the proteolytic cleavage of prolactin by the mammary gland and liver of the rat: characterization of the cleaved and 16K forms. Endocrinology. 121: 2055-2064.
7. Mittra I. (1980). A novel 'cleaved prolactin' in the rat pituitary: part II in vivo mammary mitogenic activity of its N-terminal 16K moiety. Biochem Biophys Res Commun. 95: 1760-1767.
8. Clapp C, Sears PS, Russell DH, Richards J, Levay-Young BK, Nicoll CS. (1988). Biological and immunological characterization of cleaved and 16K forms of rat prolactin. Endocrinology. 122: 2892-2898.
9. Ferrara N, Clapp C, Weiner RI. (1991). The 16K fragment of prolactin specifically inhibits basal or fibroblast growth factor stimulated growth of capillary endothelial cells. Endocrinology. 129: 896-900.
10. Clapp C, Martial JA, Guzman RC, Rentier-Delrue F, Weiner RI. (1993). The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis. Endocrinology. 133: 1292-1299.
11. Clapp C, Sears PS, Nicoll CS. (1989). Binding studies with intact rat prolactin and a 16K fragment of the hormone. Endocrinology. 125: 1054-1059.
12. Clapp C, Weiner RI. (1992). A specific, high affinity, saturable binding site for the 16-kilodalton fragment of prolactin on capillary endothelial cells. Endocrinology. 130: 1380-1386.
13. Andries M, Clapp C, Denef C. (1993). A cleaved prolactin variant and 16 kDa prolactin stimulate DNA synthesis in different pituitary cell types. VIth International Prolactin Congress, Paris, August 30 - September 3. Neuroendocrinology. (suppl. 1): 23.
14. Tilemans D, Andries M, Proost P, Devreese B, Van Beeumen J, Denef C (1994). In vitro evidence that an 11-kilodalton N-terminal fragment of proopiomelanocortin is a growth factor specifically stimulating the development of lactotrophs in rat pituitary during postnatal life. Endocrinology. 135: 168-174.
15. Tilemans D, Andries M, Denef C. (1992). Luteinizing hormone-releasing hormone and neuropeptide Y influence deoxyribonucleic acid replication in three anterior pituitary cell types. Evidence for mediation by growth factors released from gonadotrophs. Endocrinology. 130: 882-894.
16. Cosman D (1993). The hematopoietin receptor superfamily. Cytokine. 5: 95-106.
17. Morel G, Ouhtit A, Kelly PA. (1995). Prolactin receptor immunoreactivity in rat anterior pituitary. Neuroendocrinology. 59: 78-84.
18. Kelly PA, Dijane J, Edery M. (1995). Different forms of the prolactin receptor. Insights into the mechanism of prolactin action. TEM. 3: 54-59.
19. Harlow E, Lane D. (1988). Antibodies: a laboratory manual. Cold Spring Harbor, New York.