The pituitary-adrenal axis and the different behavioral effects of buspirone and chlordiazepoxide

Pharmacology Biochemistry and Behavior

Volumn 54, Issue 1, 1996, Pages 51-56

  Mcnaughton, Neil ^b   Panickar, Kiran S ^a,b   Logan, Barbara ^b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

adrenals; anxiolytic; buspirone; chlordiazepoxide; corticosterone; fixed interval; metyrapone; pituitary; stress

Indexed keywords

ANXIOLYTIC AGENT; BENZODIAZEPINE; BUSPIRONE; CHLORDIAZEPOXIDE; CORTICOSTERONE; METYRAPONE; SEROTONIN 1A AGONIST; STEROID 11BETA HYDROXYLASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; BEHAVIOR; CONFERENCE PAPER; CONTROLLED STUDY; HYPOPHYSIS ADRENAL SYSTEM; INSTRUMENTAL CONDITIONING; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STRESS; SUBCUTANEOUS DRUG ADMINISTRATION; TRANQUILIZING ACTIVITY;

EID: 0029883865     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)02129-9     Document Type: Conference Paper

References (34)

1. Azmitia, E. C.; McNaughton, N.; Tsaltas, L.; Fillenz, M.; Gray, J. A. Interactions between hippocampal serotonin and the pituitary-adrenal axis in the septal driving of hippocampal theta-rhythm. Neuroendocrinology 39:471-475; 1984.
2. de Boer, S. F.; Slangen, J. L.; van der Gugten, J. Effects of chlordiazepoxide and buspirone on plasma catecholamine and corticosterone levels in rats under basal and stress conditions. Endocrinol. Exp. 24:229-239; 1990.
3. File, S. E.; Vellucci, S. V.; Wendlandt, S. Corticosterone-An anxiogenic or an anxiolytic agent. J. Pharm. Pharmacol. 31:300-305; 1979.
4. Gardner, C. R. Potential uses of drugs modulating 5-HT activity in the treatment of anxiety. Gen. Pharmacol. 19:347-356; 1988.
5. Glaser, T.; Traber, J. Binding of the putative anxiolytic TVX Q 7821 to hippocampal 5-hydorxytryptamine (5-HT) recognition sites. Naunyn Schmiedebergs Arch. Pharmacol. 329:211-215; 1985.
6. Goldberg, H. L.; Finnerty, R. The comparative efficacy of buspirone and diazepam in the treatment of anxiety. Am. J. Psychiatry 136:1184-1187; 1979.
7. Gray, J. A . The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system. Oxford: Oxford University Press; 1982.
8. Johnston, A. L.; File, S. E. Effects of ligands for specific 5-HT receptor subtypes in two animal tests of anxiety. In: Lader, M., ed. Buspirone: A new introduction to the treatment of anxiety. Royal Society of Medicine Service; 1988:31-41.
9. McNaughton, N. Chlordiazepoxide and successive discrimination: Different effects on acquisition and performance. Pharmacol. Biochem. Behav. 23:487-494; 1985.
10. McNaughton, N. The role of hippocampal RSA: Spatial memory vs. anxiety. In: Abraham, W. C.; Corballis, M.; White, K. G., eds. Memory mechanisms: A tribute to G. V. Goddard. Hillsdale, NJ: Lawrence Erlbaum; 1991:129-146.
11. McNaughton, N.; Coop, C. F. Neurochemically dissimilar anxiolytic drugs have common effects on hippocampal rhythmic slow activity. Neuropharmacology 30:855-863; 1991.
12. McNaughton, N. Biology and emotion. Cambridge, MA: Cambridge University Press; 1989.
13. McNaughton, N. Statistics for behavioural neuroscience. In: Sahgal, A., ed. Behavioural neuroscience: A practical approach. New York: Oxford University Press; 1993:169-188.
14. McNaughton, N.; James, D. T. D.; Stewart, J.; Gray, J. A.; Valero, I.; Drewnowski, A. Septal driving of hippocampal theta rhythm as a function of frequency in the male rat: Drug effect. Neuroscience 2:1019-1027; 1977.
15. McNaughton, N.; Morris, R. G. M. Buspirone produces a doserelated impairment in spatial navigation. Pharmacol. Biochem. Behav. 43:167-171; 1992.
16. Meert, T. F.; Colpaert, F. C. The shock probe conflict procedure. A new assay responsive to benzodiazepines, barbiturates and related compunds. Psychopharmacology (Berlin) 88:445-450; 1986.
17. Panickar, K. S. Neurobiology of anxiety. Unpublished PhD Thesis, University of Otago, New Zealand; 1992.
18. Panickar, K. S.; McNaughton, N. Dose-response analysis of the effects of buspirone on rearing in rats. J. Psychopharmacol. 5: 72-76; 1991.
19. Panickar, K. S.; McNaughton, N. Comparison of the effects of buspirone and chlordiazepoxide on successive discrimination in rats. Pharmacol. Biochem. Behav. 39:275-278; 1991.
20. Panickar, K. S.; McNaughton, N. Comparison of the effects of buspirone and chlordiazepoxide on differential reinforcement of low rates of response. Eur. J. Pharmacol. 210:307-313; 1991.
21. Panickar, K. S.; McNaughton, N. Effects of buspirone on fixed interval responding in rats. Psychopharmacology (Berlin) 5:410-417; 1991.
22. Pellow, S.; Johnstone, A. L.; File, S. E. Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes and interactions with yohimbine and FG7142 using the elevated plusmaze tests in the rat. J. Pharm. Pharmacol. 39:917-979; 1987.
23. Peroutka, S. J. Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors. Biol. Psychiatry 20:971-979; 1985.
24. Pich, E. M.; Samanin, R. Disinhibitory effectsof buspirone and low doses of sulpiride and haloperidol in two experimental anxiety models in rats: Possible role of dopamine. Psychopharmacology (Berlin) 89:125-130; 1986.
25. Taylor, D. M.; Eison, M. S.; Riblet, R. A.; Vandermaelen, C. P. Pharmacological and clinical effects of buspirone. Pharmacol. Biochem. Behav. 23:687-694; 1985.
26. Temple, D. L.; Yevich, J. P.; New, J. S. Buspirone: Chemical profile of a new class of anxioselective agents. J. Clin. Psychiatry 43:4-10; 1982.
27. Sanger, D. J.; Joly, D.; Zivkovich, B. Behavioral effects of nonbenzodiazepine anxiolytic drugs: A comparison of CGS 9896 and zopiclone with chlordiazepoxide. J. Pharmacol. Exp. Ther. 232: 831-837; 1985.
28. Schuckit, M. A. Clinical studies of buspirone. Psychopathology 17(Suppl. 3):61-68; 1984.
29. Snedecor, G. W.; Cochran, W. G. Statistical methods. Ames, IA: Iowa State University Press; 1967.
30. Wheatley, D. Buspirone, multicentre efficacy study. J. Clin. Psychiatry 43(Sect. 2):92-94; 1982.
31. Zar, J. H. Biostatistical analysis. Englewood Cliffs, NJ: Prentice Hall; 1974.
32. Zhu, X.-O.; McNaughton, N. Effects of long-term administration of anxiolytics on reticular-elicited hippocampal rhythmical slow activity. Neuropharmacology 30:1095-1099; 1991.
33. Zhu, X.-O.; McNaughton, N. Minimal changes with long-term administration of anxiolytics on septal driving of hippocampal rhythmical slow activity. Psychopharmacology (Berlin) 118:93-100; 1995.
34. Zhu, X.-O.; McNaughton, N. Similar effects of buspirone and chlordiazepoxide on a fixed interval schedule with long-term, lowdose administration. J. Psychopharmacol. 9:326-330; 1995.