Impaired renal vasodilation and urinary cGMP excretion in Dahl salt-sensitive rats

Hypertension

Volumn 27, Issue 3 II, 1996, Pages 653-657

  Simchon, Shlomoh ^a,b,c   Manger, William ^a   Blumberg, Gabriele ^c   Brensilver, Jeffrey ^c   Cortell, Stanley ^b,c  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b Columbia University ^*  (United States)

^c ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

cyclic GMP; microspheres; nitric oxide; nitroprusside; vascular resistance, renal

Indexed keywords

ATRIAL NATRIURETIC FACTOR; CYCLIC GMP; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY BLOOD FLOW; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SALT INTAKE; VASCULAR RESISTANCE; VASODILATATION;

EID: 0029883538     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.hyp.27.3.653     Document Type: Conference Paper

References (22)

1. Page IH. The kidney and salt metabolism. In: Hypertension Mechanisms. Orlando, Fla: Grune and Stratton, Inc; 1987:203-256.
2. Dahl LK, Heine M, Tassinari L. Effects of chronic salt ingestion: evidence that genetic factors play an important role in susceptibility to experimental hypertension. J Exp Med. 1962;115:1173-1190.
3. Dahl LK, Knudsen KD, Heine M, Leith GJ. Effects of chronic excess salt ingestion: modification of experimental hypertension in the rat by variations in the diet. Circ Res. 1968;22:11-18.
4. Simchon S, Manger WM, Carlin RD, Peeters LL, Rodriguez JR, Batista D, Brown T, Merchant NB, Jan KM, Brinberg DE, Chien S. Salt-induced hypertension in Dahl salt-sensitive rats: hemodynamics and renal responses. Hypertension. 1989;13:612-621.
5. Simchon S, Manger WM, Brown TW. Dual hemodynamic mechanisms for salt-induced hypertension in salt-sensitive Dahl rats. Hypertension. 1991;17:1063-1071.
6. Simchon S, Manger WM, Shi GS, Brensilver J. Impaired renal vascular reactivity in pre-hypertensive Dahl salt-sensitive rats. Hypertension. 1992;20:524-532.
7. Paul RV, Wackym PS, Warnock DG. Decreased cyclic GMP response to ANP in mesangial cells from salt-sensitive (SS-JR) compared to salt-resistant (SR-JR) rats. Hypertension. 1993;22:431. Abstract.
8. Murad F. Cyclic guanosine monophosphate as a mediator of vasodilation. J Clin Invest. 1986;78:1-5.
9. Chen RYZ, Fan F-C, Schuessler GB, Simchon S, Kim S, Chien S. Regional blood flow and oxygen consumption of the canine brain during hemorrhagic hypotension. Stroke. 1984;15:343-350.
10. Simchon S, Jan KM, Chien S. Influence of reduced red cell deformability on regional blood flow. Am J Physiol. 1987;253:H898-H903.
11. Simchon S, Jan KM, Chien S. Studies an the sequestration of neuraminidase treated red blood cells. Am J Physiol. 1988;254: H1167-H1171.
12. Simchon S, Jan KM, Chien S. Effects of sialic acid removal on red blood cell sequestration in regional microvasculatures and their interactions with macrophages. Elsevier Science Microcirc. In: Tseuchiya M, Asano Y, Mishima Y, Oda M, eds. Microcirculation/An Update. Vol 1. Proceedings of the Fourth World Congress for Microcirculation, Tokyo, Japan. New York, NY: 1987;1: 501-502.
13. Simchon S, Chien S. Effect of variations in renal hemodynamics on the time course of renin secretion rate. Am J Physiol. 1983;245: F784-F791.
14. Brooker G, Harper JF, Terasaki WL, Moylan RD. Radioimmunoassay of cyclic AMP and cyclic GMP. Adv Cyclic Nucleotide Res. 1979;10:1-33.
15. Shultz PJ, Tolins JP. Adaptation to increased dietary salt intake in the rat: role of endogenous nitric oxide. J Clin Invest. 1993;91: 642-650,
16. Lüscher TF, Raij L, Vanhoutte PM. Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats. Hypertension. 1987;9:157-163.
17. Tolins JP, Palmer RMJ, Moncada S, Raij L. Role of endothelium-derived relaxing factor in regulation of renal hemodynamic responses. Am J Physiol. 1990;258:H655-H662.
18. Chen PY, Sanders PW. L-Arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats. J Clin Invest. 1991;88:1559-1567.
19. Deng AY, Rapp JP. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. J Clin Invest. 1995;95:2170-2177.
20. Garthoff B, Kazda S. Calcium antagonist nifedipine normalizes high blood pressure and prevents mortality in salt-loaded DS substrain of Dahl rats. Eur J Pharmacol. 1981;74:111-112.
21. Luscher TF, Vanhoutte PM, Raij L. Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension. Hypertension. 1987;9(suppl III): III-193-III-197.
22. Huang C-L, Ives HE, Cogan MG. In vivo evidence that cGMP is the second messenger for atrial natriuretic factor. Proc Natl Acad Sci USA. 1986;83:8015-8018.