Effect of nitrates on myocardial remodeling after acute myocardial infarction

American Journal of Cardiology

Volumn 77, Issue 13, 1996, Pages C17-C23

  Jugdutt, Bodh I ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; FIBRINOLYTIC AGENT; GLYCERYL TRINITRATE; HYDRALAZINE; ISOSORBIDE 5 NITRATE; ISOSORBIDE DINITRATE; LISINOPRIL; LONG ACTING DRUG; NITRATE; NITROPRUSSIDE SODIUM; STREPTOKINASE; VASODILATOR AGENT;

ACUTE HEART INFARCTION; ANGINA PECTORIS; BUCCAL DRUG ADMINISTRATION; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERANCE; HEART FAILURE; HEART INFARCTION SIZE; HEART LEFT VENTRICLE FUNCTION; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; META ANALYSIS; MORTALITY; MULTICENTER STUDY; NONHUMAN; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRANSDERMAL DRUG ADMINISTRATION;

ANIMALS; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; MYOCARDIAL INFARCTION; NITRATES;

EID: 0029883455     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(96)00184-1     Document Type: Article

References (90)

1. Fukuyama T, Schechtman KB, Roberts R. The effects of intravenous nitroglycerin on hemodynamics, coronary blood flow and morphologically and enzymatically estimated infarct size in conscious dogs. Circulation 1980;62:1227-1238.
2. Jugdutt BI, Becker LC, Hutchins GM, Bulkley BH, Reid PR, Kallman CH. Effect of intravenous nitroglycerin on collateral blood flow and infarct size in the conscious dog. Circulation 1981;63:17-28.
3. Jugdutt BI. Myocardial salvage by intravenous nitroglycerin in conscious dogs: Loss of beneficial effect with marked nitroglycerin-induced hypotension. Circulation 1983;68:673-684.
4. Flaherty JT, Reid PR, Kelly DT, Taylor DR, Weisfeldt ML, Pitt B. Intravenous nitroglycerin in acute myocardial infarction. Circulation 1975;51:132-139.
5. Epstein SE, Kent KM, Goldstein RE, Borer JS, Redwood DR. Reduction of ischemic injury by nitroglycerin during acute myocardial infarction. N Engl J Med 1975;292:29-35.
6. Come PC, Flaherty JT, Weisfeldt M, Green L, Becker LC, Pitt B. Reversal of the beneficial effects of intravenous nitroglycerin in patients with acute myocardial infarction by phenylephrine. N Engl J Med 1975;293:1003-1007.
7. Flaherty JT, Come PC, Baird MG, Rouleau J, Taylor DR, Weisfeldt ML, Greene HL, Becker LC, Pitt B. Effects of intravenous nitroglycerin on left ventricular function and ST segment changes in acute myocardial infarction. Br Heart J 1976;38:612-621.
8. Bussmann WD, Schofer H, Kurita H, Ganz W. Nitroglycerin in acute myocardial infarction: X. Effect of small and large doses of I.V. nitroglycerin on ST-segment deviation: experimental and clinical results. Clin Cardiol 1979;2:106-112.
9. Chiche P, Baligadoo SJ, Derrida JP. A randomized trial of prolonged nitroglycerin infusion in acute myocardial infarction. (Abstr.) Circulation 1979:59, 60(suppl II):II-165.
10. Bussmann WD, Passek D, Seidel W, Kaltenbach M. Reduction of CK and CK-MB indexes of infarct size by intravenous nitroglycerin. Circulation 1981;63:615-622.
11. Jugdutt BI, Sussex BA, Warnica JW, Rossall RE. Persistent reduction in left ventricular asynergy in patients with acute myocardial infarction by intravenous infusion of nitroglycerin. Circulation 1983;68:1264-1273.
12. Nelson GIC, Silke B, Ahuya RC, Hussain M, Taylor SH. Haemodynamic advantanges of isosorbide dinitrate over frusemide in acute heart-failure following myocardial infarction. Lancet 1983;i:730-733.
13. Jaffe AS, Geltman EM, Tiefenbrunn AJ, Ambos HD, Strauss HD, Sobel BE, Roberts R. Reduction of infarct size in patients with inferior infarction with intravenous glyceryl trinitrate. A randomized study. Br Heart J 1983;49:452-460.
14. Flaherty JT, Becker LC, Bulkley BH, Weiss JL, Gerstenblith G, Kallman CH, Silverman KJ, Wei JY, Pitt B, Weisfeldt ML. A randomized prospective trial of intravenous nitroglycerin in patients with acute myocardial infarction. Circulation 1983;68:576-588.
15. Lis Y, Bennett D, Lambert G, Robson D. A preliminary double-blind study of IV nitroglycerin in acute myocardial infarction. Intensive Care Med 1984;10:179-184.
16. Jugdutt BI. Delayed effects of early infarct-limiting therapies on healing after myocardial infarction. Circulation 1985;72:907-914.
17. Jugdutt BI. Effect of nitroglycerin and ibuprofen on left ventricular topography and rupture threshold during healing after myocardial infarction in the dog. Can J Physiol Pharmacol 1988;66:385-395.
18. Jugdutt BI, Khan MI. Effect of prolonged nitrate therapy on left ventricular remodeling after canine acute myocardial infarction. Circulation 1994; 89:2297-2307.
19. Jugdutt BI, Khan MI, Jugdutt SJ, Blinston GE. Impact of left ventricular unloading after late reperfusion of canine anterior myocardial infarction on remodeling and function using isosorbide-5-mononitrate. Circulation 1995; 92:926-934.
20. McDonald KM, Francis GS, Matthews J, Hunter D, Cohn JN. Long-term oral nitrate therapy prevents chronic ventricular remodeling in the dog. J Am Coll Cardlol 1993;21:514-522.
21. Jugdutt BI, Warnica JW. Intravenous nitroglycerin therapy to limit myocardial infarct size, expansion and complications. Effect of timing, dosage and infarct location. Circulation 1988;78:906-919.
22. Jugdutt BI, Warnica JW. Tolerance with low dose intravenous nitroglycerin therapy in acute myocardial infarction. Am J Cardiol 1989;64:581-587.
23. Michorowski BL, Tymchak WJ, Jugdutt BI. Improved left ventricular function and topography by prolonged nitroglycerin therapy after acute myocardial infarction. (Abstr.) Circulation 1987;76(suppl IV):IV-128.
24. Jugdutt BI, Tymchak WJ, Humen DP, Gulamhusein S, Tang SB. Effect of thrombolysis and prolonged captopril and nitroglycerin on infarct size and remodeling in transmural myocardial infarction. (Abstr.) J Am Coll Cardiol 1992;19:205A.
25. Jugdutt BI. Prevention of ventricular remodelling post myocardial infarction: timing and duration of therapy. Can J Cardiol 1993;9:103-114.
26. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation 1990;81:1161-1172.
27. Jugdutt BI. Modification of left ventricular remodeling after myocardial infarction. In: Dhalla NS, Beamish RE, Takeda N, Nagano M, eds. The Failing Heart. Philadelphia: Lippincott-Raven Publishers, 1995:231-245.
28. Fletcher PJ, Pfeffer JM, Pfeffer MA, Braunwald E. Left ventricular diastolic pressure-volume relations in rats with healed myocardial infarction: effects on systolic function. Circ Res 1981;49:618-626.
29. Pfeffer JM, Pfeffer MA, Fletcher PJ, Braunwald E. Progressive ventricular remodeling in rat with myocardial infarction. Am J Physiol 1991;260:H1406-1414.
30. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarcto Miocardico. GISSI-3: effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction. Lancet 1994;343:1115-1122.
31. ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group: ISIS-4: a randomized factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58050 patients with suspected acute myocardial infarction. Lancet 1995;345:669-685.
32. Hutchins GM, Bulkley BH. Infarct expansion versus extension: two different complications of acute myocardial infarction. Am J Cardiol 1978;41:1127-1132.
33. Eaton LW, Weiss JL, Bulkley BH, Garrison JB, Weisfeldt ML. Regional cardiac dilatation after acute myocardial infarction. N Engl J Med 1979;300:57-62.
34. Erlebacher JA, Weiss JL, Eaton LW, Kallman C, Weisfeldt ML, Bulkley BH. Late effects of acute infarct dilation on heart size: a two-dimensional echocardiographic study. Am J Cardiol 1982;49:1120-1126.
35. Erlebacher JA, Weiss JL, Weisfeldt ML, Bulkley BH. Early dilation of the infarcted segment in acute transmural myocardial infarction: role of infarct expansion in acute left ventricular enlargement. J Am Coll Cardiol 1984;4:201-208.
36. Jugdutt BI, Basualdo CA. Myocardial infarct expansion during indomethacin or ibuprofen therapy for symptomatic post-infarction pericarditis. Influence of other pharmacologic agents during early remodeling. Can J Cardiol 1989;5:211-221.
37. Jugdutt BI. Identification of patients prone to infarct expansion by the degree of regional shape distortion on an early two-dimensional echocardiogram after myocardial infarction. Clin Cardiol 1990;13:28-40.
38. Michorowski BL, Senaratne MRJ, Jugdutt BI. Myocardial infarct expansion. Cardiovasc Rev Rep 1987;8:42-47.
39. Michorowski BL, Senaratne MRJ, Jugdutt BI. Deterring myocardial infarct expansion. Cardiovasc Rev Rep 1987;8:55-62.
40. Gaudron P, Eilles C, Kugler I, Ertl G. Progressive left ventricular dysfunction and remodeling after myocardial infarction. Potential mechanisms and early predictors. Circulation 1993;87:755-763.
41. St. John Sutton M, Pfeffer MA, Plappert T, Rouleau J-L, Moyé LA, Dagenais GR, Lamas GA, Klein M, Sussex B, Goldman S, Menapace FJ Jr, Parker JO, Lewis S, Sestier F, Gordon DF, McEwen P, Bernstein V, Braunwald E, for the SAVE investigators. Quantitative two-dimensional echocardiographic measurements are major predictors of adverse cardiovascular effects of captopril. Circulation 1994;89:68-75.
42. Jugdutt BI. Intravenous nitroglycerin unloading in acute myocardial infarction. Am J Cardiol 1991;68(suppl):52D-63D.
43. Jugdutt BI. Effects of nitrate therapy on ventricular remodeling and function. Am J Cardiol 1993;72(suppl):161G-168G.
44. Jugdutt BI, Khan MI. Impact of infarct transmurality on remodeling and function during healing after anterior myocardial infarction in the dog. Can J Physiol Pharmacol 1992;70:949-958.
45. Weisman HF, Bush DE, Mannisi JA, Weisfeldt ML, Healy B. Cellular mechanisms of myocardial infarct expansion. Circulation 1988;78:186-201.
46. Whittaker P, Boughner DR, Kloner RA. Role of collagen in acute infarct expansion. Circulation 1991;84:2123-2124.
47. Fujiwara H, Ashraf M, Sato S, Millard R. Transmural cellular damage and blood flow distribution in early ischemia in pig heart. Circ Res 1982;51:683-693.
48. Zhao M, Zhang H, Robinson TF, Factor SM, Sonnenblick EH, Eng C. Profound structural alterations of the excellular collagen matrix in postischemic dysfunctional ("stunned") but viable myocardium. J Am Coll Cardiol 1987;10:1322-1334.
49. Jugdutt BI, Amy RWM. Healing after myocardial infarction in the dog: changes in infarct hydroxyproline and topography. J Am Coll Cardiol 1986;7:91-102.
50. Mallory GK, White PD, Salcedo-Salgar J. The speed of healing of myocardial infarction: A study of the pathological anatomy in 72 cases. Am Heart J 1939;18:647-671.
51. Hammerman H, Kloner RA, Hale S, Schoen FJ, Braunwald E. Dose-dependent effects of short-term methylprednisolone on myocardial infarct extent, scar formation, and ventricular function. Circulation 1983;68:446-452.
52. Brown EJ, Kloner RA, Schoen FJ, Hammerman H, Hale S, Braunwald E. Scar thinning due to ibuprofen administration following experimental myocardial infarction. Am J Cardiol 1983;51:877-883.
53. Bulkley BH, Roberts WC. Steroid therapy during acute myocardial infarction: A cause of delayed healing and of ventricular aneurysm. Am J Med 1974;56:244-250.
54. Boyle MP, Weisman HF. Limitation of infarct expansion and ventricular remodeling by late reperfusion. Study of time course and mechanism in a rat model. Circulation 1993;88:2872-2883.
55. Rogers WJ, Bowlby LJ, Chandra NC, French WJ, Gore JM, Lambrew CT, Rubison M, Tiefenbrunn AJ, Weaver WDX, for the Participants. Treatment of myocardial infarction in the United States (1990 to 1993). Observations from the national registry of myocardial infarction. Circulation 1994;90:2103-2114.
56. Hochman JS, Choo H. Limitation of myocardial expansion by reperfusion independent of myocardial salvage. Circulation 1987;75:299-306.
57. Reimer KA, Jennings RB. The "wavefront phenomenon" of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. Lab Invest 1979;40:633-644.
58. Force T, Kemper A, Leavitt M, Parisi AF. Acute reduction in functional infarct expansion with late coronary reperfusion: assessment with quantitative two-dimensional echocardiography. J Am Coll Cardiol 1988;11:192-200.
59. Tymchak WJ, Michorowski BL, Burton JR, Jugdutt BI. Preservation of left ventricular function and topography with combined reperfusion and intravenous nitroglycerin in acute myocardial infarction. (Abstr.) J Am Coll Cardiol 1988;11:90A.
60. Whittaker P, Boughner DR, Kloner RA. Analysis of healing after myocardial infarction using polarized light microscopy. Am J Pathol 1989;34:879-893.
61. Chien KR, Knowlton KU, Zhu H, Chien S. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J 1991;5:3037-3046.
62. Covell JW. Factors influencing diastolic function. Possible role of the extracellular matrix. Circulation 1990;81(suppl III):III-115-III-158.
63. Michel JB, Lattion AL, Salzmann JL, et al. Hormonal and cardiac effects of converting enzyme inhibition in rat myocardial infarction. Circ Res 1988;62:641-650.
64. Litwin SE, Litwin CM, Raya TE, Warner AL, Goldman S. Contractility and stiffness of non-infarcted myocardium after coronary ligation in rats. Effects of chronic angiotensin converting enzyme inhibition. Circulation 1991;83:1028-1037.
65. Olivetti G, Capasso JM, Sonnenblick EH, Anversa P. Side-to-side slippage of myocytes participates in ventricular remodeling acutely after myocardial infarction in rats. Circ Res 1990;67:23-34.
66. Beltrami CA, Finato N, Rocco M, Feruglio GA, Puricelli C, Cigola E, Quaini F, Sonnenblick EH, Olivetti G, Anversa P. Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation 1994;89:151-163.
67. van Krimpen C, Schoemaker RG, Cleutjens JPM, Smits JFM, Struyker-Boudier HAJ, Bosman FT, Daeman MJAP. Angiotensin I converting enzyme inhibitors and cardiac remodeling. Basic Res Cardiol 1991;86:149-155.
68. Schoemaker RG, Debets JJM, Struyker-Boudier HAJ, 20Smits JFM. Delayed but not immediate captopril therapy improves cardiac function in conscious rats, following myocardial infarction. J Mol Cell Cardiol 1991:23:187-197.
69. Smits JFM, van Krimpen C, Schoemaker RG, Cleutjens JPM, Daemen MJAP. Angiotensin II receptor blockade after myocardial infarction in rats: effects on hemodynamics, myocardial DNA synthesis, and interstitial collagen content. J Cardiovasc Pharmacol 1992;20:772-778.
70. Jugdutt BI. Effect of captopril and enalapril on left ventricular geometry, function and collagen during healing after anterior and inferior myocardial infarction in the dog model. J Am Coll Cardiol 1995;25:1718-1725.
71. Jugdutt BI, Khan MI, Jugdutt SJ, Blinston GE. Effect of enalapril on ventricular remodeling and function during healing after anterior myocardial infarction in the dog. Circulation 1995;91:802-812.
72. Cleutjens JPM, Verluyten MJA, Smits JFM, Daeman MJAP. Collagen remodeling after myocardial infarction in the rat heart. Am J Pathol 1995;147:325-338.
73. Jugdutt BI, Khan MI, Jugdutt SJ, Blinston GE. Combined captopril and isosorbide dinitrate during healing after myocardial infarction. Effect on ventricular remodeling, function, mass and collagen. J Am Coll Cardiol 1995;25:1089-1096.
74. Swedberg K, Held P, Kjekshus J, Rasmussen K, Ryden L, Wedel H, for the Consensus II Study Group. Effects of early administration of enalapril on mortality in patients with acute myocardial infarction. Results of the Cooperative North Scandinavian Enalapril Survival Study II (CONSENSUS H). N Engl J Med 1992;327:678-684.
75. Gunnar RM, Fisch C. Special Report: ACC/AHA guidelines for the early management of patients with acute myocardial infarction. Circulation 1990;82:664-707.
76. Yusuf S, Collins R, MacMahon S, Peto S. Effect of intravenous nitrates on mortality in acute myocardial infarction: an overview of the randomized trials. Lancet 1988;i:1088-1092.
77. Flaherty JT, Becker LC, Weiss JL, Brinker JA, Bulkley BH, Gerstenblith G, Kallman CH, Weisfeldt ML. Results of a randomized prospective trial of intraaortic balloon counterpulsation and intravenous nitroglycerin in patients with acute myocardial infarction. J Am Coll Cardiol 1985;56:434-446.
78. Hildebrandt P, Torp-Pedersen C, Joen T, Iversen E, Jensen G, Jeppesen D, Melchior T, Schytten HJ, Ringsdal V, Jensen J, Steensgaard-Hansen FS, Granborg J, Hassager C, Weiss M, Ermer W. Reduced infarct size in nonreperfused myocardial infarction by combined infusion of isosorbide dinitrate and streptokinase. Am Heart J 1992;124:1139-1144.
79. Arstall MA, Yang J, Stafford I, Betts H, Horowitz JD: N-Acetylcysteine in combination with nitroglycerin and streptokinase for the treatment of evolving acute myocardial infarction: safety and biochemical effects. Circulation 1995;92:2855-2862.
80. Diodati J, Théroux P, Latour JG, Lacoste L, Lam JYT, Waters D. Effects of nitroglycerin at therapeutic doses on platelet aggregation in unstable angina pectoris and acute myocardial infarction. Am J Cardiol 1990; 66:683-688.
81. Parker JO, Amies MH, Hawkinson RW, Heilman JM, Hougham AJ, Vollmer MC, Wilson RR, and the Minitran Efficacy Study Group. Intermittent transdermal nitroglycerin therapy in angina pectoris. Clinically effective without tolerance or rebound. Circulation 1995;91:1368.
82. Gogia H, Mehra A, Parikh S, Raman M, Ajit-Uppal J, Johnson JV, Elkayam U. Prevention of tolerance to hemodynamic effects of nitrates with concomitant use of hydralazine in patients with chronic heart failure. J Am Coll Cardiol 1995;26:1515.
83. Thadani U, Hamilton SF, Olson E, Anderson JL, Prasad R, Voyles W, Doyle R, Kirsten E, Teague SM. Duration of effects and tolerance of slow-release isosorbide-5-mononitrate for angina pectoris. Am J Cardiol 1987;59:756-762.
84. Rezaković DE, Goldner V, Batinic Z, Weiss M, Stalec J, Pavicic L. Intravenous isosorbide-5-mononitrate in the treatment of acute myocardial infarction. Am J Cardiol 1990;65(suppl):50J-56J.
85. Pipilis A, Flather M, Collins R, Coats A, Conway M, Appleby P, Sleight P. Hemodynamic effects of captopril and isosorbide mononitrate started early in acute myocardial infarction: a randomized placebo-controlled study. J Am Coll Cardiol 1993;21:73-79.
86. Morris JL, Zaman AG, Smyllie JH, Cowan JC. Nitrates in myocardial infarction: influence on infarct size, reperfusion, and ventricular remodelling. Br Heart J 1995;73:310-319.
87. Chinese Cardiac Study Collaborative Group. Oral captopril versus placebo among 13634 patients with suspected acute myocardial infarction: interim report from the Chinese Cardiac Study (CCS-1). Lancet 1995;345:686-687.
88. Kingma JH, Van Gilst WH, Peels CH, Dambrink JHE, Verbeugt FWA, Wielenga RP. Acute intervention with captopril during thrombolysis in patients with first anterior myocardial infarction: results from the Captopril and Thrombolysis Study (CATS). Eur Heart J 1994;15:898-907.
89. Ambrosioni E, Borghi C, Magnani B, for the Survival of Myocardial Infarction Long-term Evaluation (SMILE) Study Investigators. The effect of the angiotensin-converting-enzyme inhibitor zofenopril on mortality and morbidity after anterior myocardial infarction. N Engl J Med 1995;332:80-85.
90. Latini R, Maggioni AP, Flather M, Sleight P, Tognoni G, for the meeting participants. ACE inhibitor use in patients with myocardial infarction. Summary of evidence from clinical trials. Circulation 1995;92:3132-3137.