Isoaromatization of 4-alkylidene-3-oxo-1-cyclohexene-1-carboxylates. Convenient synthesis of methyl 4-alkyl-3-hydroxybenzoates †

Journal of Organic Chemistry

Volumn 61, Issue 14, 1996, Pages 4806-4809

  Campbell, Erin ^a   Martin, John J ^a   Bordner, Jon ^a   Kleinman, Edward F ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYBENZOIC ACID DERIVATIVE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; TECHNIQUE;

EID: 0029883221     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9522724     Document Type: Article

References (22)

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7. Reference 1d describes the synthesis of 2,6-dialkyl-, 2,3,6-trialkyl-, and 2,4,6-trialkylphenols by high-temperature, transition metal-catalyzed isoaromatization of the corresponding 2,6-dialkyl-idenecyclohexanones. All subsituents in the 2- and 6-positions are identical. The reaction was shown to proceed via 6-alkylidine-2-cyclohexen-1-one intermediates.
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21. The author has deposited atomic coordinates for these structures with the Cambridge Crystallographic Data Centre. The coordinates can be obtained, on request, from Director, Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, CB2 1EZ, UK.
22. A computer-assisted substructure search of the Cambridge Structural Data Base was performed.