Pain and dermal reaction caused by injected glycerin in immunotherapy solutions

Journal of Allergy and Clinical Immunology

Volumn 97, Issue 5, 1996, Pages 1033-1039

  Van Metre Jr , Thomas E ^a   Rosenberg, Gary L ^a   Vaswani, Surender K ^a   Ziegler, Sharon R ^a   Adkinson, N Franklin ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

bruising; dose; erythema; Glycerin; human serum albumin saline; immunotherapy solution; induration; pain; potency

Indexed keywords

GLYCEROL; HUMAN SERUM ALBUMIN;

ADULT; ALLERGIC REACTION; ARTICLE; CAPILLARY RESISTANCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DILUTION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG POTENCY; FEMALE; HUMAN; HUMAN EXPERIMENT; IMMUNOTHERAPY; MALE; NORMAL HUMAN; PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; SKIN IRRITATION; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0029882965     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(96)70254-3     Document Type: Article

References (10)

1. Center JG, Shuller N, Zeleznick LD. Stability of antigen E in commercially prepared ragweed pollen extracts. J Allergy Clin Immunol 1974;54:305-10.
2. Baer H, Hooton ML. The effects of preservatives on the stability of short ragweed pollen extract. Dev Biol Stand 1974;24:115-21.
3. Nelson HS. The effect of preservatives and conditions of storage on the potency of allergy extract. J Allergy Clin Immunol 1981;67:64-9.
4. Anderson MC, Baer H. Antigenic and allergenic changes during storage of a pollen extract. J Allergy Clin Immunol 1982;69:3-10.
5. Van Metre TE, Adkinson NF. Immunotherapy for aeroallergen disease. In: Middleton E Jr, Reed CE, Ellis EF, Adkinson NF Jr, Yunginger JW, Busse WW, editors. Allergy: principles and practice. 4th ed. St Louis: Mosby, 1993:1498.
6. Turkeltaub PC, Rastogi SC, Baer H, Anderson MC, Norman PS. A standardized quantitative skin test assay of allergen potency and stability: studies on the allergen dose response curve and effect of wheal, erythema, and patient selection on assay results. J Allergy Clin Immunol 1982;70: 343-52.
7. Siegel S. Nonparametric statistics. New York: McGraw-Hill, 1956.
8. Zar JH. Biostatistical analysis. 2nd ed. Englewood Cliffs, NJ: Prentice-Hall, 1984.
9. Glantz SA, Slinker BK. Primer of applied regression and analysis of variance. New York: McGraw-Hill, 1990.
10. Swinyard EA, Pathak MA. Surface-acting drugs. In: Gilman AG, Goodman LS, Gilman A, editors. Goodman and Gilman's the pharmacologic basis of therapeutics. 6th ed. New York: Macmillan Publishing 1980:951-2.