Histopathologic findings in 107 uterine leiomyomas treated with leuprolide acetate compared with 126 controls

American Journal of Surgical Pathology

Volumn 20, Issue 4, 1996, Pages 427-432

  Sreenan, Joseph J ^a   Prayson, Richard A ^a   Biscotti, Charles V ^a   Thornton, Melvin H ^a   Easley, Kirk A ^a   Hart, William R ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Leiomyoma; Leuprolide acetate; Uterus

Indexed keywords

ANDROGEN; DANAZOL; GONADORELIN AGONIST; LEUPRORELIN;

ADULT; ARTICLE; CANCER SURGERY; CLINICAL FEATURE; CONTROLLED STUDY; ECHOGRAPHY; FEMALE; HISTOLOGY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTRAMUSCULAR DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MEDICAL RECORD; MITOSIS RATE; SUBCUTANEOUS DRUG ADMINISTRATION; TUMOR VOLUME; UTERUS MYOMA; UTERUS SURGERY;

ADULT; ANTINEOPLASTIC AGENTS, HORMONAL; CLUSTER ANALYSIS; FEMALE; HUMANS; LEIOMYOMA; LEUPROLIDE; LOGISTIC MODELS; REGRESSION ANALYSIS; UTERINE NEOPLASMS;

EID: 0029882819     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-199604000-00005     Document Type: Article

References (27)

1. Adamson GD. Treatment of uterine fibroids: current findings with gonadotropin-releasing hormone agonists. Am J Obstet Gynecol 1992;166:746-51.
2. August C, Kepic T, Meier L, Valle J. Histologic findings in uterine leiomyomata of women treated with gonadotropin-releasing hormone agonists. Am J Clin Pathol 1992;97:448A.
3. Buttram VCJ, Reiter RC. Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril 1981;36: 433-5.
4. Colgan TJ, Pendergast S, LeBlanc M. The histopathology of uterine leiomyoma following treatment with gonadotropin-releasing hormone analogues. Hum Pathol 1993;24:1073-7.
5. Collins RL, Biscotti CV, Sultana CJ. Histopathologic changes of uterine leiomyoma treated with leuprolide acetate. In: Lunenfeld B, ed. GnRH analogues and cancer. Park Ridge: New Jersey, Parthenon Publishing Group, 1990:177-81.
6. Crow J, Gardner RL, McSweeney G, Shaw RW. Morphological changes in uterine leiomyomas treated by GnRH agonist goserelin. Int J Gynecol Pathol 1995;14:235-42.
7. Demopoulos R, Jones K, Mittal K. Histology of leiomyomata in lupron treated patients. Mod Pathol 1995;8:88A.
8. Friedman AJ, Harrison-Atlas D, Barbieri RL, Benacerraf B, Gleason R, Schiff I. A randomized, placebo-controlled, double-blind study evaluating the efficacy of leuprolide acetate depot in the treatment of uterine leiomyomata. Fertil Steril 1989;51:251-6.
9. Friedman AJ, Hoffman DI, Comite F, Browneller RW, Miller JD. Treatment of leiomyomata uteri with leuprolide acetate depot: a double-blind, placebo-controlled, multicenter study. Obstet Gynecol 1991;77:720-5.
10. Friedman AJ, Lobel SM, Rein MS, Barbieri RL. Efficacy and safety considerations in women with uterine leiomyomas treated with gonadotropin-releasing hormone agonists: the estrogen threshold hypothesis. Am J Obstet Gynecol 1990;163:1114-9.
11. Friedman AJ, Rein MS, Harrison-Atlas D, Garfield JM, Doubilet PM. A randomized, placebo-controlled, double-blind study evaluating leuprolide acetate depot treatment before myomectomy. Fertil Steril 1989;52:728-33.
12. Gutmann JN, Thornton KL, Diamond MP, Carcangiu ML. Evaluation of leuprolide acetate treatment on histopathology of uterine myomata. Fertil Steril 1994;61:622-6.
13. Hitti IF, Glasberg SS, McKenzie C. Uterine leiomyosarcoma with massive necrosis diagnosed during gonadotropin-releasing hormone analog therapy for presumed uterine fibroid. Fertil Steril 1991;56:778-80.
14. Letterie GS, Shawker TH, Coddington CC, Loriaux DL, Winkel CA, Collins RL. Efficacy of a gonadotropin-releasing hormone agonist in the treatment of uterine leiomyomata: long term follow-up. Fertil Steril 1989;51:951-6.
15. Loong EPL, Wong FWS. Uterine leiomyosarcoma diagnosed during treatment with agonist of luteinizing hormone-releasing hormone for presumed uterine fibroid. Fertil Steril 1990;54:530-1.
16. Meldrum DR, Chang RJ, Lu J, Vale W, Rivier J, Judd HL. Medical oophorectomy using a long-acting GnRH agonist - a possible new approach to the treatment of endometriosis. J Clin Endocrinol Metab 1982;54:1081-3.
17. Meyer WR, Mayer AR, Diamond MP, Carcangiu ML, Schwartz PE, DeCherney AH. Unsuspected leiomyosarcoma: treatment with a gonadotropin-releasing hormone analogue. Obstet Gynecol 1990;75:529-31.
18. 6-luteinizing hormone-releasing hormone. Fertil Steril 1987;48:383-9.
19. Pollow K, Sinnecker G, Boquoi E, Follow B. In vitro conversion of estradiol-17-β into estrone in normal human myometrium and leiomyoma. J Clin Chem Clin Biochem 1978; 16:493.
20. Prayson RA, Hart WR. Pathologic considerations of uterine smooth muscle tumors. Obstet Gynecol Clin North Am 1995;22:637-57.
21. Prayson RA, Hart WR. Mitotically active leiomyomas of the uterus. Am J Clin Pathol 1992;97:14-20.
22. Qu Y. Latent variable models for clustered ordinal data. Biometrics 1995;51:268-75.
23. Qu Y, Williams GW, Beck GJ, Medendorp SV. Latent variable models for clustered dichotomous data with multiple subclusters. Biometrics 1992;48:1095-102.
24. Rein MS, Friedman AJ, Stuart JM, MacLaughlin DT. Fibroid and myometrial steroid receptors in women treated with gonadotropin-releasing hormone agonist leuprolide acetate. Fertil Steril 1990;53:1018-23.
25. Reinsch RC, Murphy AA, Morales AJ, Yen SSC. The effects of RU 486 and leuprolide acetate on uterine artery blood flow in the fibroid uterus: a prospective, randomized study. Am J Obstet Gynecol 1994;170:1623-8.
26. Smiddy M, Silverberg SG. Pathologic features of uterine leiomyomas following treatment with leuprolide acetate. Am J Clin Pathol 1992;97:448A.
27. Upadhyaya NB, Doody MC, Googe PB. Histopathological changes in leiomyomata treated with leuprolide acetate. Fertil Steril 1990;54:811-4.