Phenobarbital in the anticonvulsant dose range does not impair learning and memory or alter brain AChE activity or monoamine levels

Pharmacology Biochemistry and Behavior

Volumn 54, Issue 3, 1996, Pages 633-638

  Sudha, S ^a   Lakshmana, M K ^a   Pradhan, N ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

AChE activity; Learning and memory; Monoamines; Phenobarbital; Plasma PB levels

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; ANTICONVULSIVE AGENT; DOPAMINE; HOMOVANILLIC ACID; MONOAMINE; PHENOBARBITAL; SEROTONIN;

ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVITY; ENZYME ASSAY; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; LEARNING; MALE; MAZE TEST; MEMORY; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; RAT;

EID: 0029882550     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)02283-X     Document Type: Article

References (47)

1. Aigner, T. G.; Mishkin, M. The effects of physostigmine and scopolamine on recognition memory in monkeys. Behav. Neural. Biol. 45:81-87; 1986.
2. Archer, T.; Ogren, S. O.; Johansson, C. The acute effect of p-chloroamphetamine on the retention of fear conditioning in the rat: Evidence for a role of serotonin in memory consolidation. Neurosci. Lett. 25:75-81; 1981.
3. Bartus, R. T.; Dean, R. L.; Beer, B.; Lippa, A. S. The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-417; 1982.
4. 2 dopaminergic regulation of acetylcholine release from striatum of freely moving rats. J. Neurochem. 54:2145-2148; 1990.
5. de Boer, T.; Stoof, J. C.; Van Duijn, H. The effect of convulsant and anticonvulsant drugs on the release of radio labeled GABA, glutamate, noradrenaline, serotonin and acetylcholine from rat cortical slices. Brain Res. 253:153-160; 1990.
6. Biegon, A.; Greenberger, V.; Segal, M. Quantitative histochemistry of brain acetylcholine esterase and learning in the aged rat. Neurobiol. Aging 7:215-217; 1986.
7. Bracs, P. U.; Gregory, P.; Jackson, D. M. Passive avoidance in rats: Disruption by dopamine applied to the nucleus accumbens. Psychopharmacology (Berlin) 83:70-75; 1984.
8. Decker, M. W.; McGaugh, J. L. The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse 7:151-168; 1991.
9. Dodrill, C. B.; Troupin, A. S. Neuropsychological effects of carbamazepine and phenytoin: A reanalysis. Neurology 41:141-143; 1991.
10. Ellman, G. L.; Courtney, K. D.; Valentino, A., Jr.; Featherstone, R. M. A new and rapid colorimetric determination of acetylcholine esterase activity. Biochem. Pharmacol. 7:88-95; 1961.
11. Essman, W. B. Age dependent effects of 5-hydroxytryptamine upon memory consolidation and cerebral protein synthesis. Pharmacol. Biochem. Behav. 1:7-14; 1973.
12. Essman, W. B. Serotonin in learning and memory. In: Essman, W. B., ed. Serotonin in health and disease. Vol. 3. The central nervous system. New York: Spectrum; 1978:69-143.
13. Fibiger, H. C.; Lepaine, F. G.; Phillips, A. G. Disruption of memory produced by stimulation of the dorsal raphé nucleus: Mediation by serotonin. Brain Res. 155:380-386; 1978.
14. Fibiger, H. C. Cholinergic mechanisms in learning, memory, and dementia: A review of recent evidence. Trends Neurosci. 14:220-223; 1991.
15. 3H]-dopa in various regions of the brain. J. Neurochem. 13:655-669; 1966.
16. Grecksch, G.; Matthies, H. The role of dopaminergic mechanisms in the rat hippocampus for the consolidation in a brightness discrimination. Psychopharmacology (Berlin) 75:165-168; 1981.
17. Harell, L. E.; Barlow, T. S.; Parsons, D. Cholinergic neurons, learning, and recovery of function. Behav. Neurosci. 101:644-52; 1987.
18. Haroutunian, V.; Kanof, P. D.; Tsuboyama, G.; Davis, K. L. Restoration of cholinomimetic activity by clonidine in cholinergic plus noradrenergic lesioned rats. Brain Res. 507:261-266; 1990.
19. Hass, H. L. Amine neurotransmitter actions in the hippocampus. In: Seifert, W., ed. Neurobiology of the hippocampus. London: Academic Press: 1983:139-55.
20. Hellstrom, B.; Barlach-Christoffersen, M. Influence of phenobarbital on the psychomotor development and behavior in preschool children with convulsions. Neuropaediatrie 11:151; 1980.
21. Hutt, S. J.; Jackson, P. M.; Belsham, A.; Higgins, G. Perceptual-motor behavior in relation to blood phenobarbitone level: A preliminary report. Dev. Med. Child Neurol. 10:626-632; 1968.
22. Ichihara, K.; Nabeshima, T.; Kameyama, T. Opposite effects induced by low and high doses of apomorphine on single-trial passive avoidance learning in mice. Pharmacol. Biochem. Behav. 30:107-113; 1987.
23. Itoh, J.; Nabeshima, T.; Kameyama, T. Utility of an elevated plus-maze for the evaluation of memory in mice: Effects of nootropics, scopolamine and electro convulsive shock. Psychopharmacology (Berlin) 101:27-33; 1990.
24. Jobe, P. C. Role of central neurotransmitters in the anticonvulsant effects of phenobarbital. In: Nelson, K. B.; Ellenberg, J. H., eds. Febrile seizures. New York: Raven Press; 1981:169.
25. Joyce, D.; Hurwitz, H. M. B. Avoidance behavior in the rat after 5-hydroxytryptophan administration. Psychopharmacologia 5:424-430; 1964.
26. Kametami, H.; Bresnahan, E. L.; Chachich, M. E.; Spangler, E. L.; Ingram, D. K. Comparison of retention performance between young rats with fimbria-fornix lesions and aged rats in a 14-unit T-maze. Behav. Brain Res. 35:253-63; 1989.
27. Kameyama, T.; Nabeshima, T.; Noda, Y. Cholinergic modulation of memory for step-down type passive avoidance task in mice. Res. Commun. Psychol. Psychiatr. Behav. 11:193-205; 1986.
28. Kuschinsky, K.; Seidel, G.; Reetz, E.; Burgdorf, M. C. The effect of phenobarbital on brain 5-HT metabolism in mice. Experientia (Basel) 29:826-827; 1973.
29. Levey, A. J.; Wainer, B. H.; Mufson, E. Y.; Mesulam, M. M. Co-localization of acetylcholine esterase and choline acetyltransferase in the rat cerebrum. Neuroscience 9:9-22; 1983.
30. Macleod, C. M.; DeKalan, A. S.; Hunt, E. Memory impairment in epileptic patients: Selective effects of phenobarbital concentration. Science 202:1102-1104; 1978.
31. 2 antagonists on drug-induced impairment of passive avoidance response in mice: Comparison with acetylcholine esterase inhibitors. Psychopharmacology (Berlin) 112:134-141; 1993.
32. Matthews, D. A.; Salvaterra, P. M.; Crawford, G. D.; Houser, C. R.; Vaughn, J. E. An immunocytochemical study of choline acetyl transferase-containing neurons and axon terminals in normal and partially deafferented hippocampal formation. Brain Res. 402:30-43; 1987.
33. Mattson, J. A.; Cramer, J. A. Phenobarbital toxicity. In: Levy, R.; Mattson, R.; Meldrum, B.; Penry, J. K.; Dreifuss, F. E., eds. Antiepileptic drugs. New York: Raven Press; 1989:341-355.
34. Mc Lennan, H.; Elliot, K. A. C. Effect of convulsant and narcotic drugs on acetylcholine synthesis. J. Pharmacol. Exp. Ther. 103:35-43; 1951.
35. Mondadori, C.; Classen, W. The effects of various antiepileptic drugs on E-shock induced amnesia in mice: Dissociability of effects on convulsions and effects on memory. Acta Neurol. Scand. 69(Suppl. 99): 125-129; 1984.
36. Ogren, S. O. Central serotonin neurons and learning in the rat. In: Osborne, N. N., ed. Biology of serotonergic transmission. London: John Wiley & Sons; 1982:317-334.
37. O'Neill, B. B.; Ladon, B.; Harris, L. M.; et al. A comprehensive interdisciplinary approach to the care of the institutionalized epileptic. Epilepsia 18:243-250; 1977.
38. Owasoyo, J. O.; Walker, C. A.; Whitworth, U. G. Diurnal variation in the dopamine level of rat brain areas: Effect of sodium phenobarbital. Life Sci. 25:119-122; 1979.
39. Pradhan, N.; Arunasmitha, S.; Udaya, H. B. Behavioral and neurochemical differences in an inbred strain of rats. Physiol. Behav. 47:705-708; 1990.
40. Rostock, A.; Siegmund, C. Antiepileptic drugs and cognitive functions: Investigations in rats. Epilepsia 34(Suppl. 2):51; 1993.
41. Singh, P.; Huot, L. J. Neurochemistry of epilepsy and mechanism of action of antiepileptics. In: Mercier, J., ed. Anticonvulsant drugs. Oxford: Pergamon Press; 1973:427-504.
42. Sudha, S.; Lakshmana, M. K.; Pradhan, N. Changes in learning and memory, acetylcholinesterase activity and monoamines in brain after chronic carbamazepine administration in rats. Epilepsia 36(4):416-422; 1995.
43. Sudha, S.; Lakshmana, M. K.; Pradhan, N. Chronic phenytoin induced impairment of learning and memory with associated changes in brain acetylcholinesterase activity and monoamine levels. Physiol. Pharmacol. Behav. 52(1):119-124; 1995.
44. Trimble, M. R.; Thompson, P. J. Memory, anticonvulsant drugs and seizures. Acta Neurol. Scand. 64(Suppl. 89):31-41; 1981.
45. Weinberger, S. B.; Killam, E. K. Alterations in learning performance in the seizure prone baboons: Effects of elicited seizures and chronic treatment with diazepam and phenobarbital. Epilepsia 19:301-316; 1978.
46. Wolf, S. M.; Forsythe, A.; Stunden, A. A.; Friedman, R.; Diamond, H. Longterm effect of phenobarbital on cognitive function in children with febrile convulsions. Pediatrics 68:820-823; 1981.
47. Yanai, J.; Sze, P. Y. Adrenal glucocorticoids as a required factor in barbiturate-induced changes in functional tolerance and brain stem tryptophan hydroxylase. Brain Res. 269:297-302; 1983.