Zolpidem functionally discriminates subtypes of native GABAa receptors in acutely dissociated rat striatal and cerebellar neurons

Neuropharmacology

Volumn 35, Issue 2, 1996, Pages 137-145

  Itier, V ^a   Depoortere, H ^a   Scatton, B ^a   Avenet, P ^a  

^a SANOFI   (France)

Author keywords

Acute dissociation; GABAa receptor; Patch clamp; Purkinje neurons; Striatum; benzodiazepine modulatory site

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; CHLORIDE CHANNEL; DIAZEPAM; RECEPTOR SUBTYPE; ZOLPIDEM;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL SPECIFICITY; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENTIATION; MEMBRANE CURRENT; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PURKINJE CELL; RAT; RECEPTOR AFFINITY; RECEPTOR INTRINSIC ACTIVITY;

ANIMALS; CORPUS STRIATUM; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; HYPNOTICS AND SEDATIVES; NEURONS; PATCH-CLAMP TECHNIQUES; PURKINJE CELLS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A;

EID: 0029882456     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(95)00158-1     Document Type: Article

References (34)

1. A receptor. Neurosci. Abstract 18: 402.
2. A receptors in acutely dissociated rat cerebellar Purkinje cells. Neurosci. Abstract 19: 1144.
3. Benavides J., Peny B., Ruano D., Vitorica J. and Scatton B. (1993) Comparative autoradiographic distribution of central ω (benzodiazepine) modulatory site subtypes with high, intermediate and low affinity for zolpidem and alpidem. Brain Res. 604: 240-250.
4. A receptor structure and function. J. Biol. Chem. 267: 16747-16750.
5. Depoortere H., Zivkovic B., Lloyd K. G., Sander D. J., Perrault G., Langer S. Z. and Bartholini G. (1986) Zolpidem, a novel non-benzodiazepine hypnotic. I. Neuropharmacological and behavioral effects. J. Pharmac. Exp. Ther. 237: 649-658.
6. Depoortere H., Decobert M., Riou-Merle F. and Granger P. (1988) Pharmaco-EEG profile of zolpidem: an imidazopyridone hypnotic agent. In: Imidazopyridine in sleep disorders (Sauvanet J.P., Langer S.Z. and Morselli P.L., Eds), pp. 81-96. Raven Press, New York.
7. A receptors transiently expressed in HEK 293 cells. Can. J. Physiol. Pharmac. 72:(Suppl. 1) 338.
8. Doble A. and Martin I. L. (1992) Multiple benzodiazepine receptors: no reason for anxiety. Trends Pharmac. Sci. 13: 76-81.
9. A receptors. J. Pharmac. Exp. Ther. 272: 438-445.
10. A receptor. Int. Rev. Neurobiol. 36: 51-96.
11. Ebert B., Wafford K. A., Whiting P. J., Krogsgaard-Larsen P. and Kemp J. A. (1994) Molecular pharmacology of γ-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different α, β and γ receptor subunit combinations. Molec. Pharmac. 46: 957-963.
12. A receptor. Eur. J. Pharmac. (Molec. Pharmac. Sect.) 246: 283-287.
13. A receptors. Molec. Pharmac. 43: 970-975.
14. Hamil O. P., Marty A., Neher E., Sakmann B. and Sigworth F. J. (1981) Improved patch-clamp techniques for hight resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391: 85-100.
15. 2L sub-units stably transfected into mouse fibroblast L-cells. Br. J. Pharmac. 107: 732-737.
16. A receptor activation. Br. J. Pharmac. 108: 711-716.
17. Langer S. Z. and Arbilla S. (1988) Limitations of the benzodiazepine receptor nomenclature: a proposal for a pharmacological classification as omega receptor subtypes. Fundam. Clin. Pharmac. 2: 159-170.
18. A receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J. Neurosci. 12: 4151-4172.
19. Llano I., Leresche N. and Marty A. (1991). Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currents. Neuron 6: 565-574.
20. Lüddens H., Seeburg P. H. and Korpi E. R. (1994) Impact of β and γ variants on ligand-binding properties of γ-aminobutyric acid type A receptors. Molec. Pharmac. 45: 810-814.
21. A receptor population with novel subunit combinations and drug binding profiles identified in brain by α5-and δ-subunit-specific immunopurification. J. Biol. Chem. 268: 5965-5973.
22. Nakagawa T., Wakamori M., Shirasaki T., Nakaye T. and Akaike N. (1991) γ-Aminobutyric acid-induced response in acutely isolated nucleus solitarii neurons of the rat. Am. J. Physiol. 260: C745-C749.
23. Oh D. J. and Dichter M. A. (1992) Desensitization of GABA-induced currents in cultured rat hippocampal neurons. Neuroscience 49: 571-576.
24. Olsen R. W. (1982) Drug interactions at the GABA receptor-ionophore complex. Ann. Rev. Pharmac. Toxicol. 22: 245-277.
25. Perrault G., Morel E., Sanger D. J. and Zivkovic B. (1992) Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem. J. Pharmac. Exp. Ther. 263: 298-303.
26. 5-subunit creates novel type II benzodiazepine receptor pharmacology. J. Neurochem. 54: 1802-1804.
27. - currents. Molec. Pharmac. 39: 691-696.
28. Regan L. J. (1991) Voltage-dependent calcium currents in Purkinje cells from rat cerebellar vermis. J. Neurosci. 11: 2259-2269.
29. A receptors. Eur. J. Neurosci. 5: 1042-1049.
30. A receptor by intracellular ATP in dissociated nucleus tractus solitarii neurones of rat. J. Physiol. 449: 551-572.
31. A receptors depend upon subunit composition. Neuron 4: 919-928.
32. A receptor subtypes. Molec. Pharmac. 43: 240-244.
33. A/BZ receptor subtypes. In: GABAergic Synaptic Transmission (Biggio G., Concas A. and Costa E., Eds), pp. 29-40. Raven Press, New York.
34. Yakushiji T., Shirasaki T., Munakata M., Hirata A. and Akaike N. (1993) Differential properties of type I and type II benzodiazepine receptors in mammalian CNS neurones. Br. J. Pharmac. 109: 819-825.