Influence of local cytokines on tumor metastasis: Using cytokine gene-transfected tumor cells as experimental models

Current Topics in Microbiology and Immunology

Volumn 213 III, Issue , 1996, Pages 54-64

  Qin, Z ^a   Blankenstein, T ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; TUMOR VACCINE;

EXPERIMENTAL MODEL; GENE THERAPY; GENE TRANSFER; HUMAN; METASTASIS; PRIORITY JOURNAL; REVIEW; VACCINATION;

ANIMALS; CYTOKINES; HUMANS; INTERFERON-GAMMA, RECOMBINANT; MICE; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; VACCINATION;

EID: 0029882381     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-80071-9_4     Document Type: Article

References (25)

1. Allione A, Consalvo M, P, Lollini PL, Cavallo F, Giovarelli M, Forni M, Gulino A, Colombo MP, Dellabona P, Hock H, Blankenstein T, Rosenthal FM, Gansbacher B, Musso T, Forni G (1994) Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants Cancer Res 54: 6022-6026
2. Beutler B, Cerami A (1989) The biology of cachectin/TNF-a primary mediator of the host response. Annu Rev Immunol 7. 625-655
3. Blankenstein T (1994a) Increasing tumour immunogenicity by genetic modification. Eur J Cancer 30A 1182-1187
4. Blankenstein T (1994b) Observations with tumor necrosis factor gene-transfected tumours Folia Biol Praha 40: 19-28
5. Cavallo F, Di Pierro F, Giovarelli M, Gulino A, Vacca A, Stoppacciaro A, Forni M, Modesti A, Forni G (1993) Protective and curative potential of vaccination with interleukin-2-gene-transfected cells from a spontaneous mouse mammary adenocarcinoma Cancer Res 53. 5067-5070
6. Colombo MP, Forni G (1994) Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now? Immunol Today 15: 48
7. Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, Brose K, Jackson V, Hamada H, Pardoll D, Mulligan RC (1993) Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting antitumor immunity. Proc Natl Acad Sci USA 90: 3539-3543
8. Dye ES, North RJ, Mills CD (1981) Mechanisms of anti-tumor action of Corynebacterium parvum I. Potentiated tumor-specific immunity and its therapeutic limitations. J Exp Med 154: 609-620
9. Ferrantini M, Proietti E, Santodonato L, Gabriele L, Peretti M, Plavec I, Meyer F, Kaido T, Gresser I, Belardelli F (1993) α1-Interferon gene transfer into metastatic Friend leukemia cells abrogated tumorgenictity in immunocompetent mice: antitumor therapy by means of interferon-producing cells. Cancer Res 53: 1107-1112
10. + T cell-mediated tumor rejection and development of antitumor immunity. J Immunol 153: 4604-4615
11. Gresser I (1989) Antitumor effects of interferon. Acta Oncol 28: 347-353
12. Havell EA, Fiers W, North RJ (1988) The antitumor function of tumor necrosis factor (TNF). 1. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity. J Exp Med 167: 1067-1085
13. Hock H, Dorsch M, Kunzendorf U, Uberla K, Qin Z, Diamantstein T, Blankenstein T (1993) Vaccinations with tumor cells genetically engineered to produce different cytokines: effectively not superior to a classical adjuvant Cancer Res 53: 714-716
14. Lollini P-L, Bosco MC, Cavallo F, De Govanni C, Govarelli M, Landuzzi L, Musiani P, Modesti A, Nicaletti G, Palmieri G, Sautoni A, Young HA, Forni G, Nanni P (1993) Inhibition of tumor growth and enhancement of metastasis after transfection of the gamma-interferon gene. Int J Cancer 55: 320-339
15. Miele ME, Bennett CF, Miller BE, Welch DR (1994) Enhanced metastatic ability of TNF-α-treated malignant melanoma cells is reduced by intercellular adhesion molecule-1 (ICAM-1, CD54) antisense oligonucleotides. Exp Cell Res 214: 231-241
16. Mule JJ, McIntosh JK, Jablons DM, Rosenberg SA (1990) Antitumor acitivity of recombinant interleukin 6 in mice. J Exp Med 171: 629-636
17. Pardoll DM (1993) New strategies for enhancing the immunogenicity of tumors. Curr Opin Immunol 5: 719
18. Porgador A, Tzehoval E, Katz A, Vadai E, Revel M, Feldman M, Eisenbach L (1992) Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells Cancer Res 52: 3679-3686
19. Porgador A, Gansbacher B, Bannerji R, Tzehoval E, Gilboa E, Feldman M, Eisenbach L (1993a) Antimetastatic vaccination of tumor-bearing mice with IL-2-gene-inserted tumor cells. Int J Cancer 53. 471-477
20. Porgador A, Bannerji R, Watanabe Y, Feldman M, Gilboa E, Eisenbach L (1993b) Anti-metastatic vaccination of tumor-bearing mice with two types of IFN-γ gene-inserted tumor cells. J Immunol 150: 1458-1470
21. Porgador A, Feldman M, Eisenbach L (1994) Immunotherapy of tumor metastasis via gene therapy. Nat Immun 13: 113-130
22. Qin Z, Krüger-Krasagakes S, Kunzendorf U, Hock H, Diamantstein T, Blankenstein T (1993) Expression of tumor necrosis factor by different tumor cell lines results either in tumor suppression or augmented metastasis. J Exp Med 178 355-360
23. Rosenberg SA, Longo DL, Lotze MT (1989) Principles and applications of biologic therapy. In. De Vita VT, Hellman S, Rosenberg SA (eds) Cancer: principles and practice of oncology, 3rd edn. Lippincott, Philadelphia, pp 301-347
24. Taniguchi K, Petersson M, Höglund, P, Kiessling R, Klein G, Kärre K (1987) Interferon-γ induces lung colonization by intravenously inoculated B16 melanoma cells in parallel with enhanced expression of class I major histocompatibility complex antigens. Proc Natl Acad Sci USA 84: 3405-3409
25. Van Snick J (1990) Interleukin-6 an overview Annu Rev Immunol 8 253-278