Micronuclei in lymphocytes of children from the vicinity of Chernobyl before and after 131I therapy for thyroid cancer

International Journal of Radiation Biology

Volumn 69, Issue 2, 1996, Pages 259-268

  Wuttke, K ^a   Streffer, C ^a   Muller W U ^a   Reiners, C ^b   Biko, J ^b   Demidchik, E ^c  

^a Inst F Med Strahlenbiologie   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c Department of Pathology   (Belarus)

Author keywords

[No Author keywords available]

Indexed keywords

IODINE 131;

ARTICLE; CHERNOBYL ACCIDENT; CHILD; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MICRONUCLEUS TEST; PRIORITY JOURNAL; THYROID CANCER;

ACCIDENTS, RADIATION; ADOLESCENT; CHILD; CHROMOSOME ABERRATIONS; DNA DAMAGE; FEMALE; HUMANS; IODINE RADIOISOTOPES; LYMPHOCYTES; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; NEOPLASMS, RADIATION-INDUCED; POWER PLANTS; THYROID NEOPLASMS; TIME FACTORS; UKRAINE;

EID: 0029881727     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530096146101     Document Type: Article

References (42)

1. BENDER, M. A., AWA, A. A., BROOKS, A. L., EVANS, H. J., GROER, P. G., LITTLEFIELD, L. G., PEREIRA, C., PRESTON, R. J. and WACHHOLZ, B. W., 1988, Current, status of cytogenetic procedures to detect and quantify previous exposures to radiation. Mutation Research, 196, 103-159.
2. BÖCKER, W., MÜLLER, W.-U. and STREFFER, C., 1994, Automated Binucleated Cell Recognition and Micronucleus Counting System, X Press Informatik 1994 (Springer Berlin), pp. 498-505.
3. BÖCKER, W., MÜLLER, W.-U. and STREFFER, C., 1995, Image processing algorithms for the automated micronucleus-assay in binucleated human lymphocytes. Cytometry, 19, 283-294.
4. BRASELMANN, H., SCHMID, E. and BAUCHINGER, M., 1992, Chromosome analysis in a population living in an area of Germany with the highest fallout deposition from the Chernobyl accident. Mutation Research, 283, 221-225.
5. CASTRONOVO, F. P., 1986, Iodine-131 thyroid burdens of European travellers returning to Boston after the Chernobyl accident. New England Journal of Medicine, 315, 1679-1680.
6. EDWARDS, A. A., LLOYD, D. C. and PURROT, R. J., 1979, Radiation-induced chromosome aberrations and the Poisson distribution. Radiation and Environmental Biophysics, 16, 89-100.
7. FENECH, M. and MORLEY, A., 1985a, Solutions to the kinetic problem in the micronucleus assay. Cytobios, 43, 233-246.
8. FENECH, M. and MORLEY, A., 1985b, Measurement of micronuclei in lymphocytes. Mutation Research, 147, 29-36.
9. GANTENBERG, H.-W., WUTTKE, K., STREFFER, C. and MÜLLER, W.-U., 1991, Micronuclei in human lymphocytes irradiated in vitro or in vivo. Radiation Research, 128, 276-281.
10. HUBER, R., BRASELMANN, H. and BAUCHINGER, M., 1989, Screening for interindividual differences in radiosensitivity by means of the micronucleus assay in human lymphocytes. Radiation and Environmental Biophysics, 28, 113-120.
11. HUBER, R., BRASELMANN, H. and BAUCHINGER, M., 1992, Inter- and intraindividual variations of background and radiation-induced micronucleus frequencies in human lymphocytes. International Journal of Radiation Biology, 61, 655-661.
12. HUBER, R., SCHRAUBE, H., NAHRSTEDT, U., BRASELMANN, H. and BAUCHINGER, M., 1994, Dose-response relationships of micronuclei in human lymphocytes induced by fission neutrons and by low LET radiations. Mutation Research, 306, 135-141.
13. INTERNATIONAL ATOMIC ENERGY AGENCY, 1986, Biological Dosimetry - Chromosomal Aberration Analysis for Dose Assessment. IAEA Technical Report Series No. 260 (IAEA, Vienna).
14. INTERNATIONAL COMMISSION OF RADIATION PROTECTION, 1988, Radiation Dose to Patients from Radiopharmaceuticals, No. 53 (ICRP), p. 274.
15. KAKATI, S., KOWALCZYK, J. R., GIBAS, Z. and SANDBERG, A. A., 1986, Use of radiation induced chromosomal damage in human lymphocytes as a biological dosimeter is questionable. Cancer Genetics and Cytogenetics, 22, 137-141.
16. KELLERER, A. M., 1991, The situation in the contaminated regions around Chernobyl and the need for remedial actions. In: Long-Term Followup of the Chernobyl Disaster (UICC), pp. 83-101.
17. 125J in the induction of micronuclei in human peripheral blood lymphocytes. Radiotherapy and Oncology, 4, 163-166.
18. LITTLEFIELD, L. G., KLEINERMANN, R. A., SAYER, A. M., TARONE, R. and BOICE, J. D., JR., 1991, Chromosome aberrations in lymphocytes - biomonitors of radiation exposure. In: New Horizons in Biological Dosimetry Edited by: B. L. Gledhill and F. Mauro (New York: Wiley Liss), pp. 387-397.
19. LIVINGSTON, G. K., FOSTER, A. F. and ELSON, H. R., 1993, Effect of in vivo exposure to iodine-131 on the frequency and persistence of micronuclei in human lymphocytes. Journal of Toxicology and Environmental Health, 40, 367-375.
20. MERZ, T., TATUM, J. and HIRSCH, J., 1986, Technelium-99-m-labeled lymphocytes: radiotoxicity study. Journal of Nuclear Medicine, 27, 105-110.
21. MÜLLER, W.-U. and STREFFER, C., 1994, Micronucleus-assays. In: Advances in Mutagenesis Research, vol. 4. Edited by: G. Obe (Berlin: Springer), pp. 1-133.
22. PADOVANI, L., CAPOROSSI, D., TEDESCHI, B., VERNOLE, P., NICOLETTI, B. and MAURO, F., 1993, Cytogenetic study in lymphocytes from children exposed to ionizing radiation after the Chernobyl accident. Mutation Research, 319, 55-60.
23. POHL-RÜLING, J., HAAS, O., BROGGER, A., OBE, G., LETTNER, H., DASCHIL, F., ATZMÜLLER, C., LLOYD, D., KUBIAK, R. and NATARAJAN, A. T., 1991, The effect of lymphocyte chromosomes of additional radiation burden due to fallout in Salzburg (Austria) from the Chernobyl accident. Mutation Research, 262, 209-217.
24. PROSSER, J. S., MOQUET, J. E., LLOYD, D. C. and EDWARDS, A. A., 1988, Radiation induction of micronuclei in human lymphocytes. Mutation Research, 199, 37-45.
25. 137Cs in the Goiania (Brazil) radiation accident: inter-comparison among four laboratories. Mutation Research, 252, 157-160.
26. RAMALHO, A. T., NASCIMENTO, A. C. H. and NATARAJAN, A. T., 1988, Dose assessments by cytogenetic analysis in the Goiania (Brazil) radiation accident. Radiation Protection Dosimetry, 25, 97-100.
27. REINERS, C., BIKO, J., BAUER, W., WUTTKE, K., STREFFER, C., VOIGT, G., PARETZKE, H., KRUGLOVA, N., DEMIDCHIK, E., ASTHAKOVA, L. and KAKAKOV, V., 1994, Radioiodine treatment of advanced thyroid cancer in children from Belarus living in highly contaminated areas. European Journal of Nuclear Medicine, 21, 743 (abs).
28. RIGHI, E. and DI POFI, M., 1987. Aspetti clinici dell'incidente di Chernobyl. La patologia da radiazioni ionizzanti. Medicina, 7, 291-308.
29. SACHS, L. (ed.), 1984, Angewandte Statistik, 6 (Springer, Berlin).
30. SCHEID, W., WEBER, J., PETRENKO, S. and TRAUT, H., 1993, Chromosome aberrations in human lymphocytes apparently induced by Chernobyl fallout. Health Physics, 64, 531-534.
31. SEVANKAEV, A. V. and ZHLOBA, A. A., 1991, Early and late radiation cytogenetic effects in man: the data on Chernobyl accident and Semipalatinsk nuclear firing ground. Acta Oncologica, 12, 201-204.
32. STEPHAN, G. and OESTREICHER, U., 1989, An increased frequency of structural chromosome aberrations in persons present in the vicinity of Chernobyl during and after the reactor accident. Is this effect caused by radiation exposure? Mutation Research, 223, 7-12.
33. STEPHAN, G. and OESTREICHER, U., 1993, Chromosome investigation of individuals living in areas of Southern Germany contaminated by fallout from the Chernobyl reactor accident. Mutation Research, 319, 189-196.
34. TEN BERGE, R. J. M., NATARAJAN, A. T., HARDEMANN, M. R., VAN ROYEN, E. A. and SCHELLEKENS, P. T. A., 1983, Labelling with indium-111 has detrimental effects on lymphocytes: concise communication. Journal of Nuclear Medicine, 24, 615-620.
35. THIERENS, H., VRAL, A. and DE RIDDER, L., 1991, Biological dosimetry using the micronucleus assay for lymphocytes: interindividual differences in dose-response. Health Physics, 61, 623-030.
36. UNION INTERNATIONALE CONTRE LE CANCER, 1987, TNM-Klassifikation maligner Tumoren. Edited by: P. Hermanek, O. Scheibe, B. Speissel, G. Wagner (Springer, Berlin), pp. 36-37.
37. VERSCHAEVE, L., DOMRACHEVA, K. V., KUZNETSOV, S. A. and NECHAI, V. V., 1993, Chromosome aberrations in inhibitants of Byelorussia: consequence of the Chernobyl accident. Mutation Research, 287, 253-259.
38. 60Co γ-rays in human peripheral lymphocytes. International Journal of Radiation Biology, 65, 321-328.
39. WUTTKE, K., 1993, Mikronuklei in Lymphocyten als biologischer Indikator für Strahlen-Expositionen. PhD thesis, Universität-Gesamthochschule Essen.
40. WUTTKE, K., MÜLLER, W.-U. and STREFFER, C., 1994, Micronucleus-expression in human lymphocytes after in vitro exposure to X-rays, neutrons or neutrons followed by X-rays. European Society for Radiation Biology, Amsterdam, abstract, p. 137.
41. WUTTKE, K., STREFFER, C. and MÜLLER, W.-U., 1993, Radiation-induced micronuclei in subpopulations of human lymphocytes. Mutation Research, 286, 181-188.
42. ZOETELIEF, J. and BROERSE, J. J., 1990, Dosimetry for radiation accidents: present status and prospects for biological dosemeters. International Journal of Radiation Biology, 57, 737-750.