Allosteric interactions between cyclothiazide and AMPA/kainate receptor antagonists

British Journal of Pharmacology

Volumn 117, Issue 8, 1996, Pages 1663-1672

  Yamada, Kelvin A ^a   Turetsky, Dorothy M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AMPA receptor modulation; Benzothiadiazide; Benzothiadiazine; Cyclothiazide; Dorsal root ganglion; GYKI; Hippocampus; Thiazide

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR; CYCLOTHIAZIDE; KAINIC ACID RECEPTOR;

ALLOSTERISM; ANIMAL CELL; ARTICLE; DRUG POTENTIATION; HIPPOCAMPUS; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL GANGLION;

EID: 0029881648     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15337.x     Document Type: Article

References (35)

1. BETTLER, B., BOULTER, J., HERMANS-BORGMEYER, I., O'SHEA-GREENFIELD, A., DENERIS, E.S., MOLL, C., BORGMEYER, U., HOLLMANN, M. & HEINEMANN, S. (1990). Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development. Neuron, 5, 583-595.
2. BOULTER, J., HOLLMANN, M., O'SHEA-GREENFIELD, A., HARTLEY, M., DENERIS, E., MARON, C. & HEINEMANN, S. (1990). Molecular cloning and functional expression of glutamate receptor subunit genes. Science, 249, 1033-1037.
3. DONEVAN, S.D. & ROGAWSKI, M.A. (1993). GYKI 52466, A 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/Kainate receptor responses. Neuron, 10, 51-59.
4. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pfluegers Arch, 391, 85-100.
5. HERB, A., BURNASHEV, N., WERNER, P., SAKMANN, B., WISDEN, W. & SEEBURG, P.H. (1992). The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits. Neuron, 8, 775-785.
6. HOLLMANN, M., O'SHEA-GREENFIELD, A., ROGERS, S.W. & HEINEMANN, S. (1989). Cloning by functional expression of a member of the glutamate receptor family. Nature, 342, 643-648.
7. HUETTNER, J.E. (1990). Glutamate receptor channels in rat DRG neurons: activation by kainate and quisqualate and blockade of desensitization by con A. Neuron, 5, 255-266.
8. HUETTNER, J.E. & BAUGHMAN, R.W. (1986). Primary culture of identified neurons from the visual cortex of postnatal rats. J. Neurosci., 6, 3044-3060.
9. HUETTNER, J.E. & WILDING, T.J. (1995). Differential antagonism of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring and kainate-preferring receptors by 2,3-benzodiazepines. Mol. Pharmacol., 47, 582-587.
10. JOHANSEN, T.H., CHAUDHARY, A. & VERDOORN, T.A. (1995). Interactions among GYKI-52466, cyclothiazide, and aniracetam at recombinant AMPA and Kainate receptors. Mol. Pharmacol., 48, 946-955.
11. JONAS, P. & SAKMANN, B. (1992). Glutamate receptor channels in isolated patches from CA1 and CA3 pyramidal cells of rat hippocampal slices. J. Physiol., 455, 143-171.
12. KEINANEN, K., WISDEN, W., SOMMER, B., WERNER, P., HERB, A., VERDOORN, T.A., SAKMANN, B. & SEEBURG, P.H. (1990). A family of AMPA-selective glutamate receptors. Science, 249, 556-560.
13. KESSLER, M., ARAI, A., QUAN, A. & LYNCH, G. (1996). Effect of cyclothiazide on binding properties of AMPA-type glutamate receptors - lack of competition between cyclothiazide and GYKI 52466. Mol. Pharmacol., 49, 123-131.
14. LIVSEY, C.T., COSTA, E. & VICINI, S. (1993). Glutamate-activated currents in outside-out patches from spiny versus aspiny hilar neurons of rat hippocampal slices. J. Neurosci., 13, 5324-5333.
15. LOMELI, H., MOSBACHER, J., MELCHER, T., HOGER, T., GEIGER, J.R.P., KUNER, T., MONYER, H., HIGUCHI, M., BACH, A. & SEEBURG, P.H. (1994). Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science, 266, 1709-1713.
16. MOUDY, A.M., YAMADA, K.A. & ROTHMAN, S.M. (1994). Rapid desensitization determines the pharmacology of glutamate neurotoxicity. Neuropharmacology, 33, 953-962.
17. NELLGARD, B. & WIELOCH, T. (1992). Postischemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischemia. J. Cerebral Blood Flow Metab., 12, 2-11.
18. PARTIN, K.M. & MAYER, M.L. (1996). Negative allosteric modulation of wild-type and mutant AMPA receptors by GYKI 53655. Mol. Pharmacol., 49, 142-148.
19. PARTIN, K.M., BOWIE, D. & MAYER, M.L. (1995). Structural determinants of allosteric regulation in alternatively spliced AMPA receptors. Neuron, 14, 833-843.
20. PARTIN, K.M., PATNEAU, D.K. & MAYER, M.L. (1994). Cyclothiazide differentially modulates desensitization of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants. Mol. Pharmacol., 46, 129-138.
21. PARTIN, K.M., PATNEAU, D.K., WINTERS, C.A., MAYER, M.L. & BUONANNO, A. (1993). Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavilin A. Neuron, 11, 1069-1082.
22. PATERNAIN, A.V., MORALES, M. & LERMA, J. (1995). Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron, 14, 185-189.
23. PATNEAU, D.K., VYKLICKY, L.J. & MAYER, M.L. (1993). Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate. J. Neurosci., 13, 3496-3509.
24. RAMAN, I.M. & TRUSSELL, L.O. (1992). The kinetics of the response to glutamate and kainate in neurons of the avian cochlear nucleus. Neuron, 9, 173-186.
25. SHARP, R.L., MAY, P.C., MAYNE, N.G., SNYDER, Y.M. & BURNETT, J.P. (1994). Cyclothiazide potentiates agonist responses at human AMPA/kainate receptors expressed in oocytes. Eur. J. Pharmacol., 266, R1-R2.
26. SHEARDOWN, M.J., NIELSEN, E.O., HANSEN, A.J., JACOBSEN, P. & HONORE, T. (1990), 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia. Science, 241, 571-574.
27. SOMMER, B., KEINANEN, K., VERDOORN, T.A., WISDEN, W., BURNASHEV, N., HERB, A., KOHLER, M., TAKAGI, T., SAKMANN, B. & SEEBURG, P.H. (1990). Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science, 249, 1580-1585.
28. STERN-BACH, Y., BETTLER, B., HARTLEY, M., SHEPPARD, P.O., O'HARA, P.J. & HEINEMANN, S. (1994). Agonist selectivity is specified by two domains structurally related to bacterial amino acid-binding proteins. Neuron, 13, 1345-1357.
29. TANG, C.M., DICHTER, M. & MORAD, M. (1989). Quisqualate activates a rapidly inactivating high conductance ionic channel in hippocampal neurons. Science, 243, 1474-1477.
30. TARNAWA, I., FARKAS, S., BERZSENYI, P., PATAKI, A. & ANDRASI, F. (1989). Electrophysiological studies with a 2,3-benzodiazepine muscle relaxant: GYKI 52466. Eur. J. Pharmacol., 167, 193-199.
31. TRUSSELL, L.O., THIO, L.L., ZORUMSKI, C.F. & FISCHBACH, G.D. (1988). Rapid desensitization of glutamate receptors in vertebrate central neurons. Proc. Natl. Acad. Sci. U.S.A., 85, 4562-4566.
32. WONG, L.A. & MAYER, M.L. (1993). Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha - amino - 3 - hydroxy - 5-methyl-4-isoxazolepropionic acid-and kainate-preferring glutamate receptors. Mol. Pharmacol., 44, 504-510.
33. YAMADA, K.A. & TANG, C.-M. (1993). Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutama-tergic synaptic currents. J. Neurosci., 13, 3904-3915.
34. ZIVKOVIC, I., THOMPSON, D.M., BERTOLINO, M., UZUNOV, D., DIBELLA, M., COSTA, E. & GUIDOTTI, A. (1995). 7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization. J. Pharmacol. Exp. Ther., 272, 300-309.
35. ZORUMSKI, C.F., YAMADA, K.A., PRICE, M.T. & OLNEY, J.W. (1993). A benzodiazepine recognition site associated with the non-nmda glutamate receptor. Neuron, 10, 61-67.