Structural analysis of a biologically active echistatin analogue des(46-49)-[Ala8,37]-echistatin γ with three disulfide bonds by 2D-NMR and computer graphics

Biochemical and Biophysical Research Communications

Volumn 220, Issue 2, 1996, Pages 246-254

  Chuang, Li Chin ^a   Chen, Pei Yeh ^a   Chen, Chinpan ^a   Huang, Tai Huang ^a   Wang, Kung Tsung ^a   Chiou, Shyh Horng ^a   Wu, Shih Hsiung ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBOCYTIC AGENT; ECHISTATIN; ECHISTATIN DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTICOAGULATION; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPUTER GRAPHICS; CONTROLLED STUDY; DISULFIDE BOND; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION;

AMINO ACID SEQUENCE; CHEMISTRY, PHYSICAL; COMPUTER GRAPHICS; DISULFIDES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PLATELET AGGREGATION INHIBITORS; PROTEIN STRUCTURE, TERTIARY;

ANIMALIA;

EID: 0029881175     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1996.0422     Document Type: Article

References (32)

1. Davie, E. W., Fujikawa, K., and Kisiel, W. (1991) Biochemistry 30, 10363-10370.
2. Dennis, M. S., Henzel, W. J., Pitti, R. M., Lipari, M. T., Napier, M. A., Deisher, T. A., Bunting, S., and Lazarus, R. A. (1990) Pro. Natl. Acad. Sci. USA 87, 2471-2475.
3. Calvete, J. J., Schafer, W., Soszka, T., Lu, W., Cook, J. J., Jameson, B. A., and Niewiarowski, S. (1991) Biochemistry 30, 5225-5229.
4. Musial, J., Niewiarowski, S., Rucinski, B., Stewart, G. J., Cook, J. J., Williams, J. A., and Edmunds, L. H. (1990) Circulation 82, 261-273.
5. Gould, R. J., Polokoff, M. A., Friedman, P. A., Huang, T. F., Holt, J. C., Cook, J. J., and Niewiarowski, S. (1990) Proc. Soc. Expt. Biol. Med. 195, 168-171.
6. Huang, T. F., Sheu, J. R., Teng, C. M., Chen, S. W., and Liu, C. S. (1991) J. Biochem. 109, 328-334.
7. Ouyang, C., and Huang, T. F. (1983) Biochim Biophys. Acta. 757, 332-341.
8. Huang, T. F., Holt, J. C., Lukasiewicz, H., and Niewiarowski, S. (1987) J. Biol. Chem. 262, 16157-16163.
9. Scarborough, R. M., Rose, J. W., Hsu, M. A., Philips, D. R., Fried, V. A., Campbell, A. M., Nannizzi, L., and Charo, I. F. (1991) J. Biol. Chem. 266, 9359-9362.
10. Gan, Z-R., Gould, R. J., Jacobs, J. W., Friedman, P. A., and Polokoff, M. A. (1988) J. Biol. Chem. 263, 19827-19832.
11. Chen, Y. L., Huang, T-F., Chen, S-W., and Tsai, I-H. (1994) Biochem J. 305, 513-520.
12. Yasuda, T., Gold, H. K., Leinbach, R. C., Yaoita, H., Fallon, J. T., Guerrero, L., Napier, M. A., Bunting, S., and Collen, D. (1991) Circulation. 83, 1038-1047.
13. Cooke, R. M., Carter, B. G., Murray-Rust, P., Hartshorn, M. J., Herzyk, P., and Hubbard, R. E. (1992) Protein. Engng. 5, 473-477.
14. Calvete, J. J., Wang, Y., Mann, K., Shafer, W., Niewiarowski, S., and Stewart, G. J. (1992) FEBS Lett. 309, 316-320.
15. Gray, W. R. (1993) Protein Sci. 2, 1749-1755.
16. Saudek, V., Atkinson, R. A., and Pelton, J. T. (1991) Biochemistry. 30, 7369-7372.
17. Chen, P. Y., Wu, S. H., and Wang, K. T. (1994) Protein Engng. 7, 941-944.
18. Rance, M., Sørensen, O. W., Bodenhausen, G., Wagner, G., Ernst, R. R., and Wüthrich, K. (1983) Biochem. Biophys. Res. Commun. 117, 479-485.
19. Jeener, J., Meier, B. M., Bachmann, P., and Ernst, R. R. (1979) J. Chem. Phys. 71, 4546-4553.
20. Macura, S., Huang, Y., Suter, D., and Ernst, R. R. (1981) J. Magn. Reson. 43, 259-281.
21. Braunschweiler, L., and Ernst, R. R. (1983) J. Magn. Reson. 53, 521-528.
22. Bax, A., and Davies, D. G. (1985) J. Magn. Reson. 65, 355-360.
23. Redfield, A. G., and Kunz, S. D. (1975) J. Magn. Reson. 19, 250-254.
24. Marion, D., and Wüthrich, K. (1983) Biochem. Biophys. Res. Commun. 113, 967-974.
25. Kyte, J., and Doolittle, R. F. (1982) J. Mol. Biol. 157, 105-132.
26. Nilges, M., Clore, G. M., and Gronenborn, A. M. (1988) FEBS Letter. 229, 317-324.
27. Brünger, A. T. (1992) X-PLOR Software Manual, Version 3.1, Yale University, New Haven, Ct.
28. Brooks, B. R., Bruccoleri, R. E., Olafson, B. D., States, D. J., Swaminathan, S., and Karplus, M. (1983) J. Comput. Chem. 4, 187-217.
29. Lee, C. Y. (1979) in Advances in Cytopharmacology (Ceccarelli, B., and Clementi, F., Eds.) Vol. 3, pp. 1-16, Raven Press, New York.
30. Karlsson, E. (1979) in Snake Venoms, Handbook of Experimental Pharmacology (Lee, C. Y., Ed.) Vol. 52, pp. 159-212, Springer-Verlag Berlin.
31. Creighton, T. E. (1988) BioEssays 8, 57-64.
32. Ruoslahti, E., and Pierschbacher, D. (1987) Science 238, 491-497.