Dietary restriction induces biochemical and morphometric changes in the small intestine of nursing piglets

Journal of Nutrition

Volumn 126, Issue 4, 1996, Pages 933-944

  Núñez, María C ^a   Bueno, Juan D ^b   Ayudarte, María V ^a   Almendros, Antonio ^b   Ríos, Antonio ^b   Suárez, María D ^b   Gil, Angel ^a,b  

^a ABBOTT LABORATORIES   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

biochemical changes; dietary restriction; histological changes; pigs; small intestine

Indexed keywords

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL MILK; CELL INFILTRATION; CONTROLLED STUDY; CRYPT CELL; DIET RESTRICTION; HISTOPATHOLOGY; INFANT FEEDING; MALNUTRITION; MICROSCOPIC ANATOMY; NEWBORN; NONHUMAN; REPRODUCIBILITY; SMALL INTESTINE MUCOSA; SWINE;

EID: 0029881090     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/126.4.933     Document Type: Article

References (30)

1. Anderson, T. F. (1969) Techniques for the preservation of three dimensional structure in preparing specimens for the electron microscope. Trans. N.Y. Acad. Sci. 13: 130-134.
2. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254.
3. Brunser, O., Castillo, C. & Araya, M. (1976) Fine structure of the small intestinal mucosa in infantile malnutrition. Gastroenterology 70: 495-507.
4. Brunser, O., Reid, A., Mönckeberg, F., Maccioni, A. & Contreras, I. (1968) Mucosa in infant malnutrition. Am. J. Clin. Nutr. 21: 976-982.
5. Bueno, J., Torres, M., Almendros, A., Carmona, R., Núñez, M. C., Ríos, A. & Gil, A. (1994) Effect of dietary nucleotides on intestinal repair after diarrhea. Histological and ultrastructural changes. Gut 35: 926-933.
6. Butzner, J. D. & Gall, D. G. (1988) Effects of chronic protein-calorie malnutrition on small intestinal repair after an acute bacterial enteritis: a study in infant rabbits. Pediatr. Res. 23: 408-413.
7. Butzner, J. D. & Gall, G. (1990) Impact of refeeding on intestinal development and function in infant rabbits subjected to protein-energy malnutrition. Pediatr. Res. 27: 245-251.
8. Castillo, R. O., Feng, J. J., Stevenson, D. K., Kerner, J. A. & Kwong, L. K. (1990) Regulation of intestinal ontogeny by intraluminal nutrients. J. Pediatr. Gastroenterol. Nutr. 10: 199-205.
9. Dahlquist, A. (1968) Assay of intestinal disaccharidases. Anal. Biochem. 22: 99-107.
10. Dixon, W. J., Brown, M. B., Engelman, L. & Jennrich, R. I. (1990) BMDP Statistical Software Manual. University of California Press, Berkeley, CA.
11. Firmansyah, A., Suwandito, L., Penn, D. & Lebenthal, E. (1989) Biochemical and morphological changes in the digestive tract of rats after prenatal and postnatal malnutrition. Am. J. Clin. Nutr. 50: 261-268.
12. Greene, H. L., McCabe, D. R. & Merenstein, G. B. (1975) Protracted diarrhea and malnutrition in infancy: changes in intestinal morphology and disaccharidase activities during treatment with total intravenous nutrition or oral elemental diets. J. Pediatr. 5: 695-704.
13. Guiraldes, E. & Hamilton, J. R. (1981) Effect of chrome malnutrition on intestinal structure, epithelial renewal, and enzymes in suckling rats. Pediatr. Res. 15: 930-934.
14. Hatch, T. F. (1981) Effects of protein-calorie malnutrition on the digestive and absorptive capacities of infants. In: Textbook of Gastroenterology and Nutrition in Infancy (Lebenthal, E., ed.), pp. 767-777. Raven Press, New York, NY.
15. Heitlingher, L. A., Rossi, T. M., Lee, P. & Lebenthal, E. (1991) Human intestinal disaccharidase activities: correlations with age, biopsy technique, and degree of villus atrophy. J. Pediatr. Gastroenterol. Nutr. 12: 204-208.
16. Hodin, R. A., Graham, J. R., Meng, S. & Upton, M. P. (1994) Temporal pattern of rat small intestine gene expression with refeeding. Am. J. Physiol. 266: G83-G89.
17. Jambunathan, L. R., Neuhoff, D. & Younoszai, M. K. (1981) Intestinal disaccharidases in malnourished infant rats. Am. J. Clin. Nutr. 34: 1879-1884.
18. Koruda, M. J., Rolandelli, R. H., Settle, R. G. & Rombeau, J. C. (1988) Small bowel disaccharidase activity in the rat as affected by intestinal resection and pectin feeding. Am. J. Clin. Nutr. 47: 448-453.
19. Labarca, C. & Paigen, K. (1980) A simple, rapid and sensitive DNA assay procedure. Anal. Biochem. 1: 344-352.
20. Maroux, S., Louvard, D. & Baratti, J. (1973) The aminopeptidase from long intestinal brush-border. Biochim. Biophys. Acta 321: 282-295.
21. Miller, E. R. & Ullrey, D. Y. (1987) The pig as a model for human nutrition. Ann. Rev. Nutr. 7: 361-382.
22. Núñez, M. C., Ayudarte, M. V., Morales, D., Suárez, M. D. & Gil, A. (1990) Effect of dietary nucleotides on intestinal repair in rats with experimental chronic diarrhea. J. Parenter. Enteral Nutr. 14: 598-604.
23. Phillips, A. D., Smith, M. W. & Walker-Smith, J. A. (1988) Selective alteration of brush-border hydrolases in intestinal diseases in childhood. Clin. Sci. (Lond.) 74: 193-200.
24. Reynolds, E. S. (1963) The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol. 17: 208-212.
25. Shiner, M., Nichols, U. N., Barrish, J. P. & Nichols, B. C. (1990a) Pathogenesis of small-intestinal mucosal lesions in chronic diarrhea of infancy: II. An electron microscopic study. J. Pediatr. Gastroenterol. Nutr. 11: 464-480.
26. Shiner, M., Putnam, M., Nichols, U. N. & Nichols, B. L. (1990b) Pathogenesis of small-intestinal mucosal lesions in chronic diarrhea of infancy: I. A light microscopic study. J. Pediatr. Gastroenterol. Nutr. 11:455-463.
27. Sökücü, S. (1987) Enterokinase and disaccharidase activities of the small intestinal mucosa in infants with protein-energy malnutrition and in normal infants. Turk. J. Pediatr. 29: 15-24.
28. Spurr, A. R. (1969) A low viscosity epoxy resin embedding. J. Ultrastruct. Res. 26: 31-43.
29. Winick, M. & Noble, A. (1966) Cellular response in rats during malnutrition at various ages. J. Nutr. 89: 300-306.
30. Zarling, E. J. & Mobarhan, S. (1987) Effect of restricting a balanced diet on rat intestinal disaccharidase activity and intestinal architecture. J. Lab. Clin. Med. 109: 556-559.