Glycosyl derivatives of NK2 tachykinin receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 4, 1996, Pages 367-372

  Pinzani, Daniela ^a   Papini, Anna M ^a   Vallecchi, Maria E ^a   Chelli, Mario ^a   Ginanneschi, Mauro ^a   Rapi, Gianfranco ^a   Quartara, Laura ^b   Patacchini, Riccardo ^b   Maggi, Carlo A ^b   Arcamone, Federico M ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Menarini Ricerche SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MEN 10414; NEUROKININ 2 RECEPTOR; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ A [4-10][5 TYROSINE 6,8,9 DEXTRO TRYPTOPHAN 10 LYSINE]; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GLYCOSYLATION; HAMSTER; LUNG ARTERY; MALE; MASS SPECTROMETRY; NONHUMAN; RABBIT; STRUCTURE ACTIVITY RELATION; TRACHEA;

EID: 0029880897     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00039-X     Document Type: Article

References (21)

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11. 12 The final HPLC purity of the glycopeptides was always > 98%. Yields of purified glycopeptides were calculated as percentage of the theoretical yield, based on the substitution level of the resin.
12. Amino acid analyses with theoretical values in brackets. MEN 11038: Asn 0.89 (1), Asp 0.91 (1), Tyr 1.00 (1), Trp 2.91 (3), Val 0.88 (1), Lys 0.98 (1); MEN 10871: Asp 0.89 (1), Tyr 1.00 (1), Trp 1.95 (2), Val 0.87 (1); MEN 11201: Asp 0.89 (1), Tyr 1.00 (1), Trp 2.95 (3), Val 0.87 (1), Lys 0.98 (1); MEN 11202: Asp 0.87 (1), Tyr 2.00 (2), Trp 2.93 (3), Val 0.89 (1), Lys 0.97 (1); MEN 11258: Ser 0.98 (1), Asp 0.87 (1), Tyr 1.00 (1), Trp 2.93 (3), Val 0.89 (1), Lys 0.97 (1); MEN 11259: Ser 0.97 (1), Asp 0.87 (1), Tyr 1.00 (1), Trp 1.93 (2), Val 0.89 (1).
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