Activation of endogenous protein kinase C by halothane in synaptosomes

Anesthesiology

Volumn 84, Issue 3, 1996, Pages 652-662

  Hemmings Jr , Hugh C ^a,b   Adamo, Anna I B ^a  

^a Department of Anesthesiology ^*

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Anesthesia: theories; Anesthetics, volatile: halothane; Signal transduction: MARCKS; protein kinase C; protein phosphorylation

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; HALOTHANE; MARCKS PROTEIN; OKADAIC ACID; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ANESTHESIA MECHANISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; INHALATION ANESTHESIA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SYNAPTIC MEMBRANE; SYNAPTOSOME;

ANESTHETICS, INHALATION; ANIMALS; CALCIUM; CALCIUM CHANNELS; ENZYME ACTIVATION; HALOTHANE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SYNAPSINS; SYNAPTOSOMES;

EID: 0029880320     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199603000-00021     Document Type: Article

References (61)

1. Franks NP, Lieb WR: Molecular and cellular mechanisms of general anaesthesia. Nature 1994; 367:607-14
2. Nishizuka Y: Studies and perspectives of protein kinase C. Science 1986; 233:305-12
3. Hemmings HC Jr, Nairn AC, McGuinness TL, Huganir RL, Greengard P: Role of protein phosphorylation in neuronal signal transduction. FASEB J 1989; 3:1583-92
4. Roghani M, Da Silva C, Castagna M: Tumor promotor chloroform is a potent protein kinase C activator. Biochem Biophys Res Comm 1987; 142:738-44
5. Tsuchiya M, Okimasu E, Ueda W, Hirakawa M, Utsumi K: Halothane, an inhalation anesthetic, activates protein kinase C and superoxide generation by neutrophils. FEBS Lett 1988; 242:101-5
6. Deshmukh DS, Kuizon S, Chauhan VPS, Brockerhoff H: Effect of barbiturates on phosphoinositide biosynthesis and protein kinase C activity in synaptosomes. Neuropharmacology 1989; 28:1317-23
7. Tsuchiya M, Tamoda M, Ueda W, Hirakawa M: Halothane enhances the phosphorylation of H1 histone and rat brain cytoplasmic proteins by protein kinase C. Life Sci 1990; 46:819-25
8. Mikawa K, Maekawa N, Hoshina H, Tanaka O, Shirakawa J, Goto R, Obara H, Kusunoki M: Inhibitory effect of barbiturates and local anaesthetics on protein kinase C activation. J Int Med Res 1990; 18: 153-60
9. Lester DS, Baumann D: Action of organic solvents on protein kinase C. Eur J Pharmacol 1991; 206:301-8
10. 2+ ion concentration. Biochim Biophys Acta 1991; 1091:401-4
11. Yamakage M: Direct inhibitory mechanisms of halothane on canine tracheal smooth muscle contraction. ANESTHESIOLOGY 1992; 77:546-53
12. Firestone S, Firestone LL, Ferguson C, Blanck D: Staurosporine, a protein kinase C inhibitor, decreases the general anesthetic requirement in Rana pipiens tadpoles. Anesth Analg 1993; 77:1026-30
13. Saito S, Fujita T, Igarashi M: Effects of inhalational anesthetics on biochemical events in growing neuronal tips. ANESTHESIOLOGY 79: 1338-47
14. Slater SJ, Cox KJA, Lombardi JV, Ho C, Kelly MB, Rubin E, Stubbs CD: Inhibition of protein kinase C by alcohols and anesthetics. Nature 1993; 364:82-4
15. Hemmings HC Jr, Adamo AIB: Effects of halothane and propofol on purified brain protein kinase C activation. ANESTHESIOLOGY 1994; 81:147-55
16. Loeb AL, OBrien DK, Longnecker DE: Halothane inhibits bradykinin-stimulated prostacyclin production in endothelial cells. ANESTHESIOLOGY 1994; 81:931-8
17. 2-induced alterations in hepatic flow and metabolism in the perfused liver in fasted rats. Anesth Analg 1994; 79:267-73
18. Bell RM, Burns DJ: Lipid activation of protein kinase C. J Biol Chem 1991; 266:4661-4
19. Hug H, Sarre TF: Protein kinase C isoforms: Divergence in signal transduction? Biochem J 1993; 291:329-43
20. Zidovetzki R, Lester DS: The mechanism of activation of protein kinase C: A biophysical perspective. Biochim Biophys Acta 1992; 1134:261-72
21. Robinson PJ: The role of protein kinase C and its neuronal substrates dephosphin, B-50, and MARCKS in neurotransmitter release. Mol Neurobiol 1992; 5:87-130
22. Shearman MS, Sekiguchi K, Nishizuka Y: Modulation of ion channel activity: A key function of the protein kinase C enzyme family. Pharmacol Rev 1989; 41:211-37
23. Huganir RL, Greengard P: Regulation of neurotransmitter receptor desensitization by protein phosphorylation. Neuron 1990; 5: 555-67
24. Nelsestuen GL, Bazzi MD: Activation and regulation of protein kinase C enzymes. J Bioenerg Biomembr 1991; 23:43-61
25. Hemmings HC Jr, Adamo AIB, Hoffman MM: Biochemical characterization of the stimulatory effects of halothane and propofol on purified brain protein kinase C. Anesth Analg 1995; 81:1216-22
26. Nicholls DG: The glutamatergic nerve terminal. Eur J Biochem 1993; 212:613-31
27. Krueger BK, Forn J, Greengard P: Depolarization-induced phosphorylation of specific proteins, mediated by calcium ion influx, in rat brain synaptosomes. J Biol Chem 1977; 252:2764-73
28. Bradford MM: A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye-coupling. Anal Biochem 1976; 72:248-54
29. Blanck TJJ: A simple closed system for performing biochemical experiments at clinical concentrations of volatile anesthetics. Anesth Analg 1981; 60:435-6
30. Miller MS, Gandolfi AJ: A rapid and sensitive method for quantifying enflurane in whole blood. ANESTHESIOLOGY 1979; 51:542-4
31. Hemmings HC Jr, Nairn AC, Aswad DW, Greengard P: DARPP-32, a dopamine- and adenosine 3′:5′-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions: II. Purification and characterization of the phosphoprotein from bovine caudate nucleus. J Neurosci 1984; 4:99-110
32. Wang JKT, Walaas SI, Greengard P: Protein phosphorylation in nerve terminals: Comparison of calcium/calmodulin-dependent and calcium/diacylglycerol-dependent systems. J Neurosci 1988; 8: 281-8
33. Robinson PJ, Dunkley PR: Depolarization-dependent protein phosphorylation in rat cortical synaptosomes: Factors determining the magnitude of the response. J Neurochem 1983; 41: 909-18
34. r = 21,000) enriched in dopamine-innervated brain regions: Amino acid sequence of the site phosphorylated by cyclic AMP in intact cells and kinetic studies of its phosphorylation in vitro. J Biol Chem 1989; 264:7726-33
35. Hvalby Ø, Hemmings HC Jr, Paulsen O, Czernik AJ, Nairn AC, Godfraind J-M, Jensen V, Raastad M, Storm JF, Andersen P, Greengard P: Specificity of protein kinase inhibitor peptides and the induction of long-term potentiation. Proc Natl Acad Sci USA 1994; 91:4761-5
36. Cheng H-C, Kemp BE, Pearson RB, Smith AJ, Misconi L, Van Patten SM, Walsh DA: A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J Biol Chem 1986; 261:989-92
37. Haystead TAJ, Sim ATR, Carling D, Honnor RC, Tsukitani Y, Cohen P, Hardie DG: Effects of the tumor promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature 1989; 337:78-81
38. Sim ATR, Dunkley PR, Jarvie PE, Rostas JAP: Modulation of synaptosomal protein phosphorylation/dephosphorylation by calcium is antagonized by inhibition of protein phosphatases with okadaic acid. Neurosci Lett 1991; 126:203-6
39. Blackshear PJ: The MARCKS family of cellular protein kinase C substrates. J Biol Chem 1993; 268:1501-4
40. Albert KA, Walaas SI, Wang JKT, Greengard P: Widespread occurrence of "87 kDa", a major specific substrate for protein kinase C. Proc Natl Acad Sci USA 1986; 83:2822-6
41. Valtorta F, Benfenati F, Greengard P: Structure and function of the synapsins. J Biol Chem 1992; 267:7195-8
42. Huttner WB, Greengard P: Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium. Proc Natl Acad Sci USA 1979; 76:5402-6
43. Dunkley PR, Baker CM, Robinson PJ: Depolarization-dependent protein phosphorylation in rat cortical synaptosomes: Characterization of active protein kinases by phosphopeptide analysis of substrates. J Neurochem 1986; 46:1692-703
44. r "87k" substrate protein in brain synaptosomes. Proc Natl Acad Sci USA 1980; 79: 5249-53
45. Dekker LV, De Graan PNE, De Wit M, Hens JJH, Gispen WH: Depolarization-induced phosphorylation of the protein kinase C substrate B-50 (GAP-43) in rat cortical synaptosomes. J Neurochem 1990; 54:1645-52
46. Wang JKT, Walaas SI, Sihra TS, Aderem A, Greengard P: Phosphorylation and associated translocation of the 87-kDa protein, a major protein kinase C substrate, in isolated nerve terminals. Proc Natl Sci USA 1989; 86:2253-6
47. Nairn AC, Hemmings HC Jr, Greengard P: Protein kinases in the brain. Annu Rev Biochem 1985; 54:931-76
48. Chang S, Hemmings HC Jr, Aderem A: Stimulus-dependent phosphorylation of MacMARCKS, a protein kinase C substrate, in nerve termini and PC12 cells. J Biol Chem 1996; 271:1174-8
49. Clarke PR, Siddhanti SR, Cohen P, Blackshear PJ: Okadaic acid-sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate. FEBS Lett 1993; 336:37-42
50. Han Y-f, Wang W, Schendler KK, Ganjeizadeh M, Dokas LA: Protein phosphatases 1 and 2A dephosphorylate B-50 in presynaptic plasma membranes from rat brain. J Neurochem 1992; 59:364-74
51. 2+ entry preferentially effects protein dephosphorylation, phosphorylation, and glutamate release. J Biol Chem 1992; 267:1983-9
52. Forn J, Greengard P: Depolarizing agents and cyclic nucleotides regulate phosphorylation of specific neuronal proteins in rat cerebral cortex slices. Proc Natl Acad Sci USA 1978; 75:5195-9
53. Walaas SI, Greengard P: Protein phosphorylation and neuronal function. Pharmacol Rev 1991; 43:299-349
54. Strömbom U, Forn J, Dolphin AC, Greengard P: Regulation of the state of phosphorylation of specific neuronal proteins in mouse brain by in vivo administration of anesthetic and convulsant agents. Proc Natl Acad Sci USA 1979; 76:4687-90
55. Study RE: Isoflurane inhibits multiple voltage-gated calcium currents in hippocampal pyramidal neurons. ANESTHESIOLOGY 1994; 81:104-16
56. Hall AC, Lieb WR, Franks NP: Insensitivity of P-type calcium channels to inhalational and intravenous general anesthetics. ANESTHESIOLOGY 1994; 81:117-23
57. Sihra TS, Nichols RA: Mechanisms in the regulation of neurotransmitter release from brain nerve terminals: Current hypotheses. Neurochem Res 1993; 18:47-58
58. Schlame M, Hemmings HC Jr: Inhibition by volatile anesthetics of endogenous glutamate release from synaptosomes by a presynaptic mechanism. ANESTHESIOLOGY 1995; 82:1406-16
59. Nishizuka Y: Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992; 258: 607-14
60. Tanaka C, Nishizuka Y: The protein kinase C family for neuronal signaling. Annu Rev Neurosci 1994; 17:551-67
61. Oda T, Shearman MS, Nishizuka Y: Synaptosomal protein kinase C subspecies: B. Down-regulation promoted by phorbol ester and its effect on evoked norepinephrine release. J Neurochem 1991; 56: 1263-9