Zona pellucida antigens: Targets for contraceptive vaccines

American Journal of Reproductive Immunology

Volumn 35, Issue 3, 1996, Pages 163-174

  Skinner, S M ^a   Prasad, S V ^a   Ndolo, T M ^b   Dunbar, B S ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b INSTITUTE OF PRIMATE RESEARCH   (Kenya)

Author keywords

Contraceptive vaccines; Zona pellucida antigens

Indexed keywords

ANTIGEN; AUTOANTIBODY; CELL RECEPTOR; CONTRACEPTIVE VACCINE; PROTEIN; RECOMBINANT PROTEIN;

ACROSOME; AMINO ACID SEQUENCE; ANTIGENICITY; DRUG TARGETING; EXTRACELLULAR MATRIX; GRANULOSA CELL; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; INFERTILITY; NONHUMAN; OVARY DEVELOPMENT; OVARY FOLLICLE DEVELOPMENT; OVARY FUNCTION; OVARY INSUFFICIENCY; OVULATION; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; ZONA PELLUCIDA;

EID: 0029880284     PISSN: 87558920     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0897.1996.tb00026.x     Document Type: Review

References (112)

1. Peters H, McNatty KP: The Ovary. London, Granada Publishing, England, 1980.
2. Byskov AG: Primordial germ cells and regulation of meisois. In Reproduction in Mammals. CR Austin, Short RV (eds). 2nd ed. Book I. Germ cells and fertilization. Cambridge University Press, 1982.
3. Satoh M: Histogenesis and organogenesis of the gonad in human embryos J Anat 1991; 177:85-107.
4. Lee, V and Dunbar, B: Localization of Laminin in the developing rabbit and porcine ovary (Abstr for Society for the Study of Reproduction) Biol Repr Suppl, 1992.
5. Lee V, Dunbar B: Localization of laminin in the developing rabbit and pig ovary Submitted for publication.
6. Mossman HW, Duke KL: Development of the mammalian ovary. In Comparative Morphology of the Mammalian Ovary, pp 53-64. University of Wisconsin Press, Madison, Wisconsin, 1973.
7. Baird DT: The ovarian cycle. In Ovarian Endocrinology. Hillier SG (ed). Oxford, Blackwell Scientific Publications, 1991.
8. Gougeon A: Rate of follicular growth in the human ovary. In Follicular Maturation and Ovulation. R Rolland, EV van Hall, SG Hillier, KP McNatty, J Schoemaker (eds). Elsevier, North Holland, New York, pp. 155-163, 1982.
9. Gougeon A: Dynamics of human follicular growth: A morphologic perspective. In The Ovary. EY Adashi, Leung PCK (eds). Raven Press, New York, pp 21-39, 1993.
10. Fukumatsu Y, Katabuchi H, Naito M, Takeya M, Takahashi K, Okamura H: Effect of macrophages on proliferation of granulosa cells in the ovary in rats. J Reprod Fertil 96:241-249, 1993.
11. Guraya SS: Morphology, histochemistry, and biochemistry of human oogenesis and ovulation. In International Review of Cytology. Bourne GH, Danielli JF (eds). pp. 121-151 New York, Academic Press, 1974.
12. Wolgemuth D, Celenza J, Dunbar BS: Formation of the rabbit zona pellucida and its relationship to ovarian follicular development. Dev Biol 1984; 106:1-14.
13. Lee V, Dunbar B: Developmental expression of the rabbit 55-Kda zona pellucida protein and mRNA in ovarian follicles. Dev Biol 1993; 155:371-382.
14. Liang LF, Chamow SM, Dean J: Oocyte-specific expression of mouse ZP-2: developmental regulation of the zona pellucida genes. Mol Cell Biol 1990; 10:1507-1515.
15. Lee VH, Schwoebel ED, Timmons TM, Dunba, BS: Stage specific expression of zona pellucida (ZP) proteins and mRNA in granulosa cells (GC) and oocytes (Abstract #196), Biol Reprod 1991; 44(Suppl 1):101.
16. Dunbar BS, Avery S, Lee V, Prasad S, Schwahn D, Schwoebel E, Skinner S, Wilkins B: The mammalian zona pellucida: its biochemistry immunochemistry, molecular biology and developmental expression. Reprod Fertil Dev 1994; 6:59-76.
17. Eppig JJ: Mammalian oocyte development. In Ovarian Endocrinology. Hillier SG (ed). Oxford, Blackwell Scientific Publications, 1991, pp. 107-131.
18. Peters H, Levy E, Crone M: Oogenesis in rabbits. J Exp Zool 1965; 158:169-180.
19. Deanesly R: Follicle formation in guinea pigs and rabbits: a comparative study with notes on the rete ovarii. J Reprod Fertil 1975; 45:371-374.
20. Erickson GF, Magoffin DA, Dyer CA, Hofeditz C: The ovarian androgen producing cells: a review of structure/function relationships. Endocrine Rev 1985; 6:371-399.
21. Hilliard J, Spies HG, Sawyer CH: Hormonal factors regulating ovarian cholesterol mobilization and progestin secretion in intact and hypophysectomized rabbits. In The Gonads. McKerns KW (ed). New York,Appletone-Century-Crofts, 1969, pp 55-92.
22. Shimizu S, Tsuji M, Dean J: In Vitro biosynthesis of three sulfated glycoproteins of murine zonae pellucidae by oocytes grown in follicle cultureJ Biol Chem 1983; 258:5858-5863.
23. Bousquet D, Leveille MC, Roberts KD, Chapdelaine A, Bleau G: The cellular origin of the zona pellucida antigen in the human and hamster. J Exp Zool 1981; 215:215-218.
24. Leveille MC, Roberts KD, Chevaleir S, Chapdelaine A, Bleau G: Formation of the hamster zona pellucida in relation to ovarian differentiation and follicular growth. J Reprod Fertil 1987; 79:173-183.
25. Trujillo-Cenoz O, Sotelo JR: Relationships of the ovular surface with follicle cells and origin of the zona pellucida in rabbit oocytes. J Biophys Biochem Cytol 1959; 5:347-348.
26. Chiquoine AD: The development of the zona pellucida of the mammalian ovum. Am J Anat 1960; 106:149-169.
27. Sacco AG, Subramanian MG, Yurewicz EC: Active immunization of mice with porcine zonae pellucidae: immune response and effect on fertility. J Exp Zool 1981;218:405-18.
28. Maresh GA, Dunbar BS: Antigenic comparison of five species of mammalian zonae pellucidae. J Exp Zool 1987; 244:299-307.
29. Timmons T, Dunbar BS: Antigens of mammalian zona pellucida. In Current Concepts in Immunoreproduction Mathur S, Fredericks CM (eds). Hemisphere Publishing Corp, 1988, pp. 242-260.
30. Dunbar BS, Prasad SV, Timmons T. Comparative structure and function of the mammalian zonae pellucidae. In Dunbar BS, O'Rand MG (eds). A Comparative Overview of Mammalian Fertilization. New York, Plenum Press, 1991, pp 97-116.
31. Barr IG, Pearce P, Toh P-H, Funder JW: Thymic sensitivity to sex hormones develops postnatally: an in vivo and an in vitro study. J Immunol 1984; 132:1095-1099.
32. Kawashima I, Seiki K, Sakabe K, Ihara S, Akatsuka A, Katsumata Y: Localization of estrogen receptors and estrogen receptor mRNA in female mouse thymus. Thymus 1992; 20:115-121.
33. Nilsson B, Carlsson S, Damer M-G, Lindholm G, Sodergard R, von Schoultz B: Specific binding of 17-beta-estradiol in human thymus. Am J Obstet Gynecol 1984; 149:544-547.
34. Ranelletti FO, Carmignani M, Marchetti P, Natoli C, Iacobelli S: Estrogen binding by neoplastic human thymus cytosol. Eur J Cancer 1984; 16:951-955.
35. Besedovsky HO, Sorkin E: Thymus involvement in sexual maturation. Nature 1974; 249:356-358.
36. Rebar RW, Morandini IC, Erickson GF, Petze JE: The hormonal basis of reproductive defects in athymic mice: Diminished gonadotropin concentrations in prepubertal females. Endocrinology 1981; 108:120-126.
37. Bukovsky A, Presl J, Holub M: Ovarian morphology in congenitally athymic mice. Folia Biol (Praha) 1978; 24:442-444.
38. Lintern-Moore S, Pantelouris EM: Ovarian development in athymic nude mice. I. The size and popoulation of the follicle population. Mech Ageing Dev 1975; 4:385-390.
39. Lintern-Moore S, Pantelouris EM: Ovarian development in athymic nude mice. I.I The growth of the oocyte and follicle. Mech Ageing Dev 1975; 4:391-398.
40. Rebar RW, Morandini IC, Silva de Sa MF, Erickson GF, Petze JE: The importance of the thymus gland for normal reproductive function in mice. In Schwartz NB, Hunzicker-Dunn M (eds). Dynamics of Ovarian Function. New York: Raven Press, pp 285-290, 1981.
41. Wyle FA, Kent JR: Immunosuppression by sex steroid hormones. Clin Exper Immunol 1977; 27:407-415.
42. Nishizuka Y, Sakakura T: Thymus and reproduction: Sex-linked dysgenesis of the gonad after neonatal thymectomy in mice. Science 1969; 166:753-755.
43. Sakakura T, Nishizuka Y: Thymic control mechanism in ovarian development: Reconstitution of ovarian dysgenesis in thymectomized mice by replacement with thymic and other lymphoid tissues. Endocrinology 1972; 90:431-437.
44. + cells in ovarian function. Biol Reprod 1986; 34:159-169.
45. Bukovsky A, Presl J, Holub M: The ovarian follicle as a model for the cell-mediated control of tissue growth. Cell Tissue Res 1984; 236:717-724.
46. Bukovsky A, Michael SD, Presl J: Cell-mediated and neural control of morphostasis. Med Hypoth 1991; 36:261-268.
47. Hellberg P, Thomsen P, Janson PO, Brannstrom M: Leukocyte supplementation increases the luteinizing hormone-induced ovulation rate in the in vitro-perfused rat ovary. Biol Reprod 1991; 44:791-797.
48. Yanagimachi R: Mammalian Fertilization. In Knobil E, Neill JD (eds). The Physiology of Reproduction, vol. 1. New York: Raven Press, 1988, pp 135-185.
49. Epifano O, Dean J: Biology and structure of the zona pellucida: a target for immunocontraception. Reprod Fertil Dev 1994; 6:319-330.
50. Harris JD, Hibler DW, Fontenot GK, Hsu KT, Yurewicz EC, Sacco AG: Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: The ZPA, ZPB and ZPC gene families. DNA Sequence 1994; 4:361-393.
51. Ringuette MJ, Sobieski DA, Chamow SM, Dean J: Oocyte specific gene expression: molecular characterization of a cDNA coding for ZP-3, a sperm binding protein of the mouse zona pellucida. Proc Natl Acad Sci USA 1986; 83:4341-4345.
52. Ringuette MJ, Chamberlin M, Baur A, Sobieski D, Dean J: Molecular analysis of cDNA coding for ZP3, a sperm binding protein of the mouse zona pellucida. Dev Biol 1988; 127:287-295.
53. Bleil JD, Wassarman PM: Sperm-egg interactions in the mouse: sequence of events and induction of the acrosome reaction by a zona pellucida glycoprotein. Dev Biol 1983; 95:317-324.
54. r 55,000 family (ZP3) to boar sperm membrane vesicles. Mol Reprod Dev 1993; 36:382-389.
55. Dunbar BD, Dudkewicz A, Bundman DS: Proteolysis of specific porcine zona pellucida glycoproteins by boar acrosin. Biol Reprod 1985; 32:619-630.
56. Chamberlin ME, Dean J: Genomic organization of a sex specific gene: The primary sperm receptor of the mouse zona pellucida. Dev Biol 1989; 131:207-214.
57. van Duin M, Polman J, De Breet I, Ginneken K, Bunschoten H, Grootenhuis A, Brindle J, Aitken J: Recombinant human zona pellucida protein ZP3 produced by chinese hamster ovary cells induces the human sperm acrosome reaction and promotes sperm-egg interaction. Biol Reprod 1994; 51:607-617.
58. Aitkin RJ, Paterson M, Braude P, Thillaikoothan P: Evaluation of glycosylated and deglycosylated porcine zona antigens for contraceptive efficacy in vivo and in vitro. In Alexander NJ, Griffin D, Spieler JM, Waites GMH (eds): "Gamete Interaction: Prospects for Immunocontraception." New York, Wiley-Liss, 1990, pp 293-311.
59. Yamasaki N, Richardson RT, O'Rand MG: Expression of the rabbit sperm protein Sp17 in COS cells and interaction of recombinant Sp17 with the rabbit zona pellucida. Mol Reprod Dev 1995; 40:48-55.
60. Bleil J, Greve J, Wassarman PM: Identification of a secondary sperm receptor in the mouse egg zona pellucida: Role in maintenance of binding of acrosome-reacted sperm to eggs. Dev Biol 1988; 128:376-385.
61. Schwoebel ED, Vandervoort CA, Lee VH, Lo YK, Dunbar BS: Molecular analysis of the antigenicity and immunogenicity of recombinant zona pellucida antigens in a primate model. Biol Reprod 1992; 47:857-865.
62. Lee V, Schwoebel E, Prasad M, Timmons T, Cook R, Dunbar B: Isolation and characterization of a cDNA encoding the rabbit 75Kd zona pellucida protein. J Biol Chem 1993; 268:12412-12417.
63. VandeVoort CA, Schwoebel ED, Dunbar BS: Immunization of monkeys with recombinant cDNA expressed zona pellucida proteins. Fertil Steril (in press).
64. Liang L, Dean J: Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes. Dev Biol 1993; 156:399-408.
65. Schwoebel E, Prasad S, Timmons T, Cook R, Kimura H, Niu E, Cheung P, Skinner S, Avery S, Wilkins B, Dunbar BS: Isolation and characterization of a full length cDNA encoding the 55-kDa rabbit zona pellucida protein. J Biol Chem 1991; 266:7214-7219.
66. Prasad SV, Wilkins B, Skinner SM, Dunbar BS: Evaluating zona pellucida structure and function using antibodies to 55kDa ZP protein expressed in baculovirus expression system. Mol Reprod Dev (Submitted).
67. Epifano O, Dean J: Coordinate expression of the three zona pellucida genes during mouse oogenesis. Development 1995; 121:1947-1956.
68. Wassarman PM (ed): Elements of Mammalian Fertilization, Vol 1 and 2, Boca Raton, CRC Press, 1991.
69. r=55,000 family. Biol Reprod 1989; 41:523-532.
70. Florman HM, Wassarman PM: O-Linked oligosaccharide of mouse egg ZP3 account for its sperm receptor activity. Cell 1985; 41:313-324.
71. Kinloch R, Ruiz-Seiler B, Wassarman P: Genomic organization and polypeptide primary structure of zona pellucida glycoprotein, hZP3, the hamster sperm receptor. Dev Biol 1990; 142:414-421.
72. Storey B, Kopf G: Fertilization in the mouse: II Spermatozoa. In Comparative Overview of Mammalian Fertilization. Dunbar B, O'Rand M (eds). New York, Plenum Press, 1991, 167-216.
73. Beebe SJ, Lisette L, Burks D, Ishikawa M, Fuerst T, Dean J, Saling P: Recombinant Mouse ZP3 inhibits sperm binding and induces the acrosome reaction. Dev Biol 1992; 151:48-54.
74. Kinloch RA, Mortillo S, Stewart CL, Wassarman PM: Embryonal carcinoma cells transfected with ZP3 genes differentially glycosylate similar polypeptides and secrete active mouse sperm receptor. J Cell Biol 1991; 115:655-664.
75. Kinloch RA, Mortillo S, Wassarman PM: Transgenic mouse eggs with functional hamster sperm receptor in their zona pellucida. Development 1992; 115:937-946.
76. Palm VS, Sacco AG, Syner FN, Subramanian MG: Tissue specificity of porcine zona pellucida antigens tested by radioimmunoassay. Biol Reprod 1979; 21:709-712.
77. Wood DM, Liu C, Dunbar BS: Effect of alloimmunization and heteroimmunization with zonae pellucidae on fertility in rabbits. Biol Reprod 1981; 25:439-450.
78. Skinner SM, Mills T, Kirchick HJ, Dunbar BS: Immunization with zona pellucida proteins results in abnormal ovarian follicular differentiation and inhibition of gonadotropin-induced steroid secretion. Endocrinology 1984; 115:2418-2432.
79. Mahi-Brown CA, Yanagimachi R, Nelson ML, Yanagimachi H, Palrimbo N: Ovarian histopathology of bitches immunized with porcine zonae pellucidae. Am J Reprod Immunol Microbiol 1988; 18:94-103.
80. r=55,000: macromolecules. Am J Primatol 1991; 24:15-28.
81. Dunbar BS, Lo YK, Stevens V: Effect of immunization with purified porcine zona pellucida proteins on ovarian function in baboons. Fertil Steril 1989; 52:311-318.
82. Paterson M, Thillai K, Morris K, O'Byrne KT, Braude P, Williams A, Aitken RJ: Analysis of the contraceptive potential of antibodies against native and deglycosylated porcine ZP3 in vivo and in vitro. Biol Reprod 1992; 46:523-534.
83. Millar SE, Chamow SM, Baur AW, Robey F, Dean J: Vaccination with a synthetic zona pellucida peptide produces long-term contraception in female mice. Science 1989; 246:935-938.
84. Jones GR, Sacco AG, Subramanian MG, Kruger M, Zhang S, Yurewicz EC, Moghissi KS: Histology of ovaries of female rabbits immunized with deglycosylated zona pellucida macromolecules of pigs. J Reprod Fertil 1992; 95:513-525.
85. Rhim SH, Millar SE, Robey F, Luo AM, Yule T, Allen P, Dean J Tung KS: Autoimmune disease of the ovary induced by a ZP3 peptide from the mouse zona pellucida J Clin Invest 1992; 89:28-35.
86. Lou YH, Tung KK: T cell peptide of a self protein elicits autoantibody to the protein antigen. J Immunol 1993; 151:5790-5799.
87. Schutze MP, Deriand E, Prawiocki G, LeCierco C: J Immunol 1989; 142:2635-2640.
88. Scheerlinck JP, DeLeys R, Sman E, Brys L, Geldhof A, DeBaetselier P: Redistribution of a murine humoral immune response following removal of an immunodominant B cell epitope from a recombinant fusion protein. Mol Immunol 1993; 30:733-739.
89. Gulyas BJ, Gwatkin RBL, Yuan LC: Active immunization of cynomolgus monkeys (Macaca facicularis) with porcine zonae pellucidae. Gamete Res 1983; 4:299-307.
90. Peterson M, Kerr LE, Aitken RJ: Progress in characterization of zona pellucida antigens as candidates for birth control vaccine. In Kurpisz M, Fernandez N (eds). Immunology of Human Reproduction. Bios Scientific Publishers, 1995, pp 485-499.
91. Drell D, Wood D, Bundman D, Dunbar BS: Comparison of the immunological response in rats and rabbits to porcine zona pellucida. Biol Reprod 1984; 30:445-457.
92. Gupta SK, Bhatnagar P, Dunbar BS, Sehgal S: Immunohistological studies during immunization of primates with porcine zona pellucida. Fogarty Internat Center Meeting on Reproductive Immunology. P Talwar (ed). New York, Plenum Press, 1986.
93. Sehgal S, Gupta SK, Bhatnagar P: Long term effects of immunization with porcine zona pellucida on rabbit ovaries. Pathology 1989; 21:105-110.
94. Upadhyay SN, Thillaikoothan P, Bamezai A, Jayaraman S, Talwar G.P: Role of adjuvants in inhibitory influence of immunization with porcine zona pellucida antigen (ZP3) on ovarian folliculogenesis in bonnet monkeys: a morphological study. Biol Reprod 1989; 41:665-673.
95. Skinner SM, Niu EM, Bundman DS, Lo C, Dunbar BS: Use of immunoaffinity purified antibodies to zona pellucida to compare alloimmunization of male and female rabbits. J Repr Immun 1987; 12:81-92.
96. Dunbar BS: Ovarian antigens and infertility (1989: Am J Reprod Immunol 1989; 21:28-31.
97. Sacco AG, Subramanian MG, Yurewicz, EC: Heteroimmunization of squirrel monkeys (Saimiri sciureus) with a purified porcine zona antigen (PPZA): Immune response and biologic activity of antiserum. Fertil Steril 1983; 29:350-358.
98. East IJ, Mattison DR, Dean, J: Monoclonal antibodies to the major protein of the murine zona pellucida; effects in fertilization and early development. Dev Biol 1984; 104:49-56 .
99. Millar SE, Chamow SM, Baur AW, Robey F, Dean J: Vaccination with a synthetic zona pellucida peptide produces long-term contraception in female mice. Science 1989; 246:935-938.
100. Tung KS, Lou Y, Luo A, Ang J: Contraceptive vaccine assessment based on a murine ZP3 mini-autoantigen. Reprod Fertil Dev 1994; 6:349-355.
101. Skinner SM, Timmons TM, Schwoebel ED, Dunbar BS: The role of zona pellucida antigens in fertility and infertility. Immunol Allerg Clin North Am 1990; 10:185-195 .
102. Aitken RJ, Holmes E, Richardson DW, Hulme MJ: Properties of intact and univalent (Fab) antibodies raised against isolated, solubilized mouse zonae. J Reprod Fertil 1982; 66:327-334.
103. Dunbar BS, Avery S, Lee V, Prasad S, Schwann D, Schwoebel, E, Skinner S, Wilkins B: The mammalian zona pellucida: its biochemistry, immunochemistry, molecular biology and developmental expression. Reprod Fertil Devel 1994; 6, 331-347.
104. Shivers CA, Dunbar BS: Autoantibodies to zona pellucida: a possible cause for infertility in women. Science 1977; 197:1082-1084.
105. Nayudu PL, Freemann LE, Trounson AO: A quantitative indirect immunofluorescent assay for zona pellucida antibodies. J Reprod Fert 1982a; 65:67-75.
106. Nayudu PL, Freemann LE, Trounson AO: Zona pellucida antibodies in human sera J Reprod Fertil 1982b; 65:77-84.
107. Singh J, Mhaskar AM: Enzyme-linked immunosorbent determination of autoantibodies to zona pellucida as a possible cause of infertility in women. J Immunol Methods 1985; 79:133-141.
108. Czuppon AB: Solid-phase antigen immunoassay for the detection of anti-zona pellucida antibodies in clinically defined sera. J Clin Chem Clin Biochem 1987; 25:87-90.
109. Caudle MR, Shivers CA, Wild RA: Clinical significance of naturally occurring anti-zona pellucida antibodies in infertile women. Am J Reprod Immunol Microbiol 1987; 15:119-121.
110. Albini B, Ossi E, Neuland C, Noble B, Adres G: Deposition of immune complexes in the ovarian follicle of rabbits with experimental chronic serum sickness I Immunopathology. Lab Invest 1979; 415:446-453.
111. Mikulikova, L, Veselsky, L, Cerny, V, Martinek, J, Malbohan, I, and Fialova, L: Immunofluorescence detection of porcine anti-zona pellucida antibodies in sera of infertile women. Acta Univers Carolinae-Medica 1989; 35:63-68.
112. Kamada M, Daitoh T, Mori K, Maeda N, Hirano K, Irahara M, Aono T, Mor, T: Etiological implication of autoantibodies to zona pellucida in humane male infertility. Am J Reprod Immunol 1992; 28:104-109.