The role of chemotherapy in the treatment of adenocarcinoma of the pancreas

Hepato-Gastroenterology

Volumn 43, Issue 8, 1996, Pages 356-362

  Fennelly, David ^a,b   Kelsen, David P ^b  

^a Solid Tumor Division   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Adjuvant therapy; Chemotherapy; Non surgical therapy; Pancreatic adenocarcinoma

Indexed keywords

CISPLATIN; DOXORUBICIN; FLUOROURACIL; FOLINIC ACID; IFOSFAMIDE; LOMUSTINE; MITOMYCIN C;

ADVANCED CANCER; ARTICLE; BONE MARROW SUPPRESSION; CANCER CHEMOTHERAPY; CANCER SURVIVAL; DIARRHEA; HUMAN; INTRAARTERIAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIVER METASTASIS; LYMPH NODE METASTASIS; MUCOSA INFLAMMATION; ORAL DRUG ADMINISTRATION; PANCREAS ADENOCARCINOMA; PERITONEUM METASTASIS; PRIORITY JOURNAL;

ADENOCARCINOMA; ANTIBIOTICS, ANTINEOPLASTIC; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; DOXORUBICIN; FLUOROURACIL; HUMANS; LEUCOVORIN; MITOMYCINS; PANCREATIC NEOPLASMS; RANDOMIZED CONTROLLED TRIALS; STREPTOZOCIN; TREATMENT OUTCOME;

EID: 0029880180     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Arbuck SG. Overview of chemotherapy for pancreatic cancer. Int J Pancreat 1990:209-22.
2. Wils JA. Chemotherapy in pancreatic cancer: A rational pursuit? AntiCancer Drugs 1991;2:3-10.
3. Carter SK: The integration of chemotherapy into a combined modality approach for cancer treatment: VI. Pancreatic adenocarcinoma. Cancer Treat Rev. 1975;3:193.
4. Kovach JS, Moertel CG, Schutt AJ et al: A controlled study of combined 1,3-bis-(2-chlorethyl)-1- nitrosorea and 5-fluorouracil therapy for advanced gastric and pancreatic cancer. Cancer. 1974;33:563.
5. Hansen R, Quebbeman E, Ritch P, Chitambar C, Anderson T: Continuous 5-fluorouracil infusion in carcinoma of the pancreas: a phase II study. Am J Med Sci. 1988;295:91-93.
6. Tajiri H, Yashimori M, Okazaki N, Miyaji M: Phase II study of continuous infusion of 5- fluorouracil in advanced pancreatic cancer. Oncology. 1991; 48:18-21.
7. Stolinsky DC, Pugh RP, Bateman JR: 5-Fluorouracil therapy for pancreatic carcinoma. Comparison of oral and intravenous routes. Cancer Chemother Rep 1975;59:1031.
8. Schein PS, Lavin PT, Moertel CG, et al: Randomized phase II clinical trial of adriamycin in advanced measurable pancreatic carcinoma: A Gastrointestinal Tumor Study Group report. Cancer 1978;42:19.
9. Wils JA, Kok T, Wagener DJTh et al: Activity of cisplatin in adenocarcinoma of the pancreas. Eur J Cancer 1993;29A:203-4.
10. Bruhl P, Gunther V, Hoefer-Janker H et al: Results obtained with ifosfamide massive dose treatment in generalized malignant tumors. In J Clin Pharmacol 1979;14:29-39.
11. Gad-El-Mawla N. Ifosfamide treatment of pancreatic cancer. Cancer Treat Rep 1981;65;357-358.
12. Gastrointestinal Tumor Study Group. Ifosfamide: An active substance in the treatment of pancreatic carcinoma. Cancer 1989:64;2010-3.
13. Wils JA, Kok T, Wagener DJTh et al: Phase II trial with Ifosfamide in pancreatic cancer. Eur J Cancer 1993;29A:290.
14. Moertel CG, Childs DS Jr, Reitermeier RJ, Colby MY Jr, Holbrook MA. Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet. 1969;2:865-867.
15. Moertel CG, Frytak S, Hahn RG, et al. Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil) and high dose radiation + 5-fluorouracil. Cancer. 1981;48:1705-1710.
16. Gastrointestinal Tumor Study Group. Radiation therapy combined with Adriamycin or 5- Fluorouracil for the treatment of locally unresectable pancreatic carcinoma. Cancer. 1985;56:2563-2568.
17. Klaasen DJ, MacIntyre JM, Catton GE, Engstrom PF. Moertel CG. Treatment f locally unresectable cancer of the stomach and pancreas: A randomized comparison of 5-fluorouracil alone with radiation plus concurrent and maintenance 5-fluorouracil. An Eastern Cooperative Group Study. J Clin Oncol. 1985; 3:373-378.
18. Gastrointestinal Tumor Study Group: Pancreatic cancer: Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg. 1985;120:899.
19. Almoguera C, Shibata D, Forrester K, et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988;53:49.
20. Wiggans RG, Wooley PV, McDonald JS, et al: Phase II trial of streptozotocin, mitomycin C, and 5-fluorouracil (SMF) in the treatment of advanced pancreatic cancer. Cancer 1978;41:387.
21. Bukowski RM, Aberhalden RT, Hewlett JS, et al: Phase II trial of streptozotocin, mitomycin C, and 5-fluorouracil in adenocarcinoma of the pancreas. Cancer Clin Trials 1980;3:321.
22. Smith FP, Hoth DF, Levin B, et al: 5-fluorouracil, adriamycin, and mitomycin C (FAM) chemotherapy for advanced adenocarcinoma of the pancreas. Carocer 1980;46:2014-2018.
23. Bitran JD, Desser RK, Kozloff MF, et al: Treatment of melastatic pancreatic and gastric adenocarcinoma with 5-fluorouracil, adriamycin, and mitomycin C (FAM). Cancer Treat Rep 1979;63:2049.
24. Buroker T, Kim PN, Groppe C, et al. 5-FU infusion with mitomycin-C vs. 5-FU infusion with methyl-CCNU in the treatment of advanced upper gastrointestinal cancer. A Southwest Oncology Group study. Cancer. 1979;44:1215-1221.
25. Bukowski RM, Balcerzak SP, O'Bryan RM, Bonnet JD, Chen TT. Randomized trial of 5- fluorouracil and mitomycin C with or without streptozotocin for advanced pancreatic cancel. A Southwest Oncology Group Study. Cancer. 1983;52:1577-1582.
26. Oster MW, Gray R, Panasci L, et al: Chemotherapy for advanced pancreatic cancer: A comparison of 5-fluorouracil, adriamycin, and mitomycin C (FAM) with 5-fluorouracil, streptozotocin and mitomycin C (FSM). Cancer 1986;57:29.
27. Gastrointestinal Tumor Study Group: Phase II studies of drug combination in advanced pancreatic carcinoma: Fluorouracil plus doxorubicin plus mitomycin-C plus fluorouracil. J Clin Oncol. 1986;4:1794.
28. Cullinan SA, Moertel CG, Fleming TR, et al: A comparison of chemotherapeutic regimens in the treatment of advanced pancreatic and gastric carcinoma. JAMA 1985;253:2061.
29. Kelsen DP, Hudis C, Niedzwiecki D, et al: A phase II comparison trial of streptozotocin, mitomycin-C, and 5-fluorouracil with cisplatin, cytosine arabinoside, and caffeine in patients with advanced pancreatic cancel. Cancer 1991;68:965-969.
30. Gastrointestinal Tumor Study Group. Treatment of locally unresectable carcinoma of the pancreas: Comparison of combined modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. J Natl Cancer Inst. 1988;80:751-755.