Differences in agonist and antagonist activities for two indices of metabotropic glutamate receptor-stimulated phosphoinositide turnover

British Journal of Pharmacology

Volumn 117, Issue 8, 1996, Pages 1735-1743

  Mistry, Rajendra ^a   Challiss, R A John ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

( ) methylcarboxyphenylglycine; 1 aminocyclopentane 1,3 dicarboxylic acid (ACPD) diastereoisomers; Cerebral cortex (neonatal rat); Inositol 1,4,5 trisphosphate; Metabotropic glutamate receptor; Phosphoinositidase C; Phosphoinositide turnover

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; CALCIUM ION; DIZOCILPINE; EGTAZIC ACID; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; GLYCINE DERIVATIVE; INOSITOL 1,4,5 TRISPHOSPHATE; INOSITOL PHOSPHATE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHOSPHATIDYLINOSITIDE; TRITIUM;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIASTEREOISOMER; EXTRACELLULAR CALCIUM; ISOTOPE LABELING; NEWBORN; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RAT;

EID: 0029880088     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15347.x     Document Type: Article

References (44)

1. 2+ signal transduction. J. Biol. Chem., 267, 13361-13368.
2. ARAMORI, I. & NAKANISHI, S. (1992). Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. Neuron, 8, 757-765.
3. BIRSE, E.F., EATON, S.A., JANE, D.E., JONES, P.L.StJ., PORTER, R.H.P., POOK, P.C.-K., SUNTER, D.C., UDVARHELYI, P.M., WHARTON, B., ROBERTS, P.J., SALT, T.E. & WATKINS, J.C. (1994). Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience, 52, 481-488.
4. CARTMELL, J., KEMP, J.A., ALEXANDER, S.P.H., HILL, S.J. & KENDALL, D.A. (1992). Inhibition of forskolin-stimulated cyclic AMP formation by 1-aminocyclopentane-trans-1,3-dicarboxylate in guinea pig cerebral cortical slices. J. Neurochem., 58, 1964-1966.
5. CHALLISS, R.A.J., MISTRY, R., GRAY, D.W. & NAHORSKI, S.R. (1994a). Modulation of muscarinic cholinoceptor-stimulated inositol 1,4,5-trisphosphate accumulation by NMDA in neonatal rat cerebral cortex. Neuropharmacology, 33, 15-25.
6. CHALLISS, R.A.J., MISTRY, R., GRAY, D.W. & NAHORSKI, S.R. (1994b). Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S, 3R-ACPD in neonatal rat cerebral cortex. Br. J. Pharmacol., 112, 231-239.
7. CHALLISS, R.A.J. & NAHORSKI, S.R. (1991). Depolarization and agonist-stimulated changes in inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate mass accumulation in rat cerebral cortex. J. Neurochem., 57, 1042-1051.
8. CHALLISS, R.A.J. & NAHORSKI, S.R. (1993). Measurement of inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, and phosphatidylinositol 4,5-bisphosphate in brain. Methods Neurosci., 18, 224-244.
9. CHAVIS, P., NOONEY, J.M., BOCKAERT, J., FAGNI, L., FELTZ, A. & BOSSU, J.L. (1995). Facilitatory coupling between a glutamate metabotropic receptor and dihydropyridine-sensitive calcium channels in cultured cerebellar granule cells. J. Neurosci., 15, 135-143.
10. 2+ mobilization in bovine adrenal chromaffin cells. Biochem. J., 304, 469-476.
11. CURRY, K., PEET, M.J., MAGNUSON, D.S.K. & MCLENNAN, H. (1988). Synthesis, resolution, and absolute configuration of the isomers of the neuronal excitant 1-amino-1,3-cyclopentanedicarboxylic acid. J. Med. Chem., 31, 864-867.
12. DEL RIO, E., NICHOLLS, D.G. & DOWNES, C.P. (1994). Involvement of calcium influx in muscarinic cholinergic regulation of phospholipase C in cerebellar granule cells. J. Neurochem., 63, 535-543.
13. 2+ activates phospholipase C. Trends Neurosci., 11, 517-520.
14. FANG, Z. & GALLAGHER, J.P. (1992). Burst firing of rat septal neurons induced by 1S, 3R-ACPD requires influx of extracellular calcium. Eur. J. Pharmacol., 211, 281-282.
15. GREENE, C.C., SCHWINDT, P.C. & CRILL, W.E. (1994). Properties and ionic mechanisms of a metabotropic glutamate receptor-mediated slow after depolarization in neocortical neurons. J. Neurophysiol., 72, 693-704.
16. + current by metabotropic glutamate and muscarinic receptors in rat CA3 cells: mediation by G-proteins. J. Physiol., 474, 27-33.
17. HAYASHI, Y., SEKIYAMA, N., NAKANISHI, S., JANE, D.E., SUNTER, D.C., BIRSE, E.F., UDVARHELYI, P.M. & WATKINS, J.C. (1994). Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. J. Neurosci., 14, 3370-3377.
18. HAYASHI, Y., TANABE, Y., ARAMORI, I., MASU, M., SHIMAMOTO, K., OHFUNE, Y. & NAKANISHI, S. (1992). Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in CHO cells. Br. J. Pharmacol., 107, 539-543.
19. IKEDA, S.R., LOVINGER, D.M., MCCOOL, B.A. & LEWIS, D.L. (1995). Heterologous expression of metabotropic glutamate receptors in adult rat sympathetic neurons: subtype-specific coupling to ion channels. Neuron, 14, 1029-1038.
20. 2+ mobilization in rat cerebellar neurons. Eur. J. Pharmacol., 186, 363-365.
21. JOLY, C., GOMEZA, J., BRABET, I., CURRY, K., BOCKAERT, J. & PIN, J.-P. (1995). Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluRl. J. Neurosci., 15, 3970-3981.
22. JONES, P.G. & ROBERTS, P.J. (1993). Stimulation of phosphoinositide hydrolysis in the guinea-pig cortex by isomers of 1-aminocyclopentane-1,3-dicarboxylate. Mol. Neuropharmacol., 3, 17-21.
23. KEMP, M., ROBERTS, P., POOK, P., JANE, D., JONES, A., JONES, P., SUNTER, D., UDVARHELYI, P. & WATKINS, J. (1994). Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors. Eur. J. Pharmacol., 266, 187-192.
24. LAURIE, D.J., DANZEISEN, M., BODDEKE, H.W.G.M. & SOMMER, B. (1995). Ligand binding profile of the rat metabotropic glutamate receptor mGluR3 expressed in a transfected cell line. Naunyn Schmied Arch. Pharmacol., 351, 565-568.
25. LAZARENO, S. & BIRDSALL, N.J.M. (1993). Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng-Prusoff equations. Br. J. Pharmacol., 109, 1110-1119.
26. LITTMAN, L., GLATT, B.S. & ROBINSON, M.B. (1993). Multiple subtypes of excitatory amino acid receptors coupled to the hydrolysis of phosphoinositides in rat brain. J. Neurochem., 61, 586-593.
27. LOWRY, O.H., ROSEBROUGH, N.J., FARR, A.L. & RANDALL, R.J. (1951). Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265-275.
28. MANZONI, O., PRÉZEAU, L., RASSENDREN, F.A., SLADECZEK, F., CURRY, K. & BOCKAERT, J. (1992). Both enantiomers of 1-aminocyclopentane-1,3-dicarboxylate are full agonists of metabotropic glutamate receptors coupled to phospholipase. C. Mol. Pharmacol., 42, 322-327.
29. NAHORSKI, S.R. & CHALLISS, R.A.J. (1991). Modulation of receptor-mediated inositol phospholipid breakdown in the brain. Neurochem. Int., 19, 207-212.
30. NAKANISHI, S. (1994). Metabotropic glutamate receptors: synaptic transmission, modulation and plasticity. Neuron., 13, 1031-1037.
31. NICOLETTI, F., MEEK, J.L., IADAROLA, M.J., CHUANG, D.-M., ROTH, B.L. & COSTA, E. (1986). Coupling of inositol phospholipid metabolism and excitatory amino acid recognition sites in rat hippocampus. J. Neurochem., 46, 40-46.
32. PICKERING, D.S., THOMSEN, C., SUZDAK, P.D., FLETCHER, E.J., ROBITAILLE, R., SALTER, M.W., MACDONALD, J.F., HUANG, X.-P. & HAMPSON, D.R. (1993). A comparison of two alternatively spliced forms of a metabotropic glutamate receptor coupled to phosphoinositide turnover. J. Neurochem., 61, 85-92.
33. PIN, J.-P. & DUVOISIN, R. (1995). The metabotropic glutamate receptors: structure and functions. Neuropharmacology, 34, 1-26.
34. PRÉZEAU, L., CARETTE, J., HELPAP, B., CURRY, K., PIN, J.-P. & BOCKAERT, J. (1994). Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures. Mol. Pharmacol., 45, 570-577.
35. SANTI, M.R., IKONOMOVIC, S., WROBLEWSKI, J.T. & GRAYSON, D.R. (1994). Temporal and depolarization-induced changes in the absolute amounts of mRNAs encoding metabotropic glutamate receptors in cerebellar granule neurons in vitro. J. Neurochem., 63, 1207-1217.
36. SAUGSTAD, J.A., SEGERSON, T.P. & WESTBROOK, G.L. (1995). L-2-amino-3-phosphonopropionic acid competitively antagonizes metabotropic glutamate receptors 1α and 5 in Xenopus oocytes. Eur. J. Pharmacol, 289, 395-397.
37. SCHOEPP, D.D. & CONN, P.J. (1993). Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol. Sci., 14, 13-20.
38. SCHOEPP, D.D., JOHNSON, B.G., TRUE, R.A. & MONN, J.A. (1991). Comparison of (1S, 3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S, 3R-ACPD)- and 1R, 3S-ACPD-stimulated brain phosphoinositide hydrolysis. Eur. J. Pharmacol., 207, 351-353.
39. 2+ stores: activation and function. Trends Neurosci., 18, 299-306.
40. SLADECZEK, F., PIN, J.-P., RÈCASENS, M., BOCKAERT, J. & WEISS, S. (1985). Glutamate stimulates inositol phosphate formation in striatal neurones. Nature, 317, 717-719.
41. TESTA, C.M., STANDAERT, D.G., YOUNG, A.B. & PENNEY, J.B. (1994). Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat. J. Neurosci., 14, 3005-3018.
42. THOMSEN, C., MULVIHILL, E.R., HALDEMAN, B., PICKERING, D.S., HAMPSON, D.R. & SUZDAK, P.D. (1993). A pharmacological characterization of the mGluR1α subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line. Brain Res., 619, 22-28.
43. 2+ signalling in human neuroblastoma cells. Br. J. Pharmacol., 114, 1133-1142.
44. 2+ and rapid desensitization. J. Neurochem., 63, 177-185.