Cardiac injury by activated leukocytes: Effect of cyclooxygenase and lipoxygenase inhibition evaluated by electron microscopical morphometry

Journal of Molecular and Cellular Cardiology

Volumn 28, Issue 2, 1996, Pages 311-320

  Semb, A G ^a,b   Ytrehus, K ^a   Vaage, J ^a   Myklebust, R ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b AKER UNIVERSITY HOSPITAL   (Norway)

Author keywords

Cyclo oxygenase; Electron microscopy; Leukocytes; Lipoxygenase; Morphometry; Oxygen free radicals; Rat heart; Ultrastructure; Volume fractions

Indexed keywords

3 AMINO 1 (3 TRIFLUOROMETHYLPHENYL) 2 PYRAZOLINE; DIETHYLCARBAMAZINE; LIPOXYGENASE INHIBITOR; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CAPILLARY WALL; EDEMA; HEART INJURY; HEART MITOCHONDRION; HUMAN; HUMAN CELL; INFLAMMATION; ISOLATED HEART; LEUKOCYTE; MALE; MORPHOMETRICS; MYOFILAMENT; NEUTROPHIL; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALIA; LETHRINIDAE;

EID: 0029879871     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1996.0029     Document Type: Article

References (49)

1. BADDELEY AJ, GUNDERSEN HJ, CRUZ ORIVE LM, 1986. Estimation of surface area from vertical sections. J Microsc 142: 259-276.
2. BAJAJ AK, COBB MA, VIRMANI R, GAY JC, LIGHT RT, 1989. Limitation of myocardial reperfusion injury by intravenous perfluorochemicals: Role of neutrophil activation. Circulation 79: 645-656.
3. BOLLI R, 1993. Role of neutrophils in myocardial stunning after brief ischaemia: the end of a six year old controversy (1987-1993). Cardiovasc Res 27: 720-727.
4. 2- generation, respectively. J Clin Invest 85: 1150-1157.
5. DREXLER H, RIEDE U, MUNZEL T, KONIG H, FUNKE E, JUST H, 1992. Alterations of skeletal muscle in chronic heart failure. Circulation 85: 1751-1759.
6. ELLIOTT AC, SMITH GL, EISNER DA, ALLEN DG, 1992. Metabolic changes during ischaemia and their role in contractile failure. J Physiol 454: 467-490.
7. ENGLER R, 1987. Consequences of activation and adenosine-mediated inhibition of granulocytes during myocardial ischemia. Fed Proc 46: 2407-2412.
8. ENGLER RL, SCHMID SCHÖNBEIN GW, PAVELEC RS, 1983. Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog. Am J Pathol 111: 98-111.
9. ENGLER RL, DAHLGREN MD, MORRIS DD, PETERSON MA, SCHMID SCHÖNBEIN GW, 1986. Role of leukocytes in response to acute myocardial ischemia and reflow in dogs. Am J Physiol 251: H314-H323.
10. FEINMARK SJ, 1988. Cooperative synthesis of leukotrienes by leukocytes and vascular cells. Ann NY Acad Sci 524: 122-132.
11. FEINMARK SJ, 1992. The role of endothelial cell in leukotriene biosynthesis. Am Rev Respir Dis 146: S51-S55.
12. GOTTLIEB RA, BURLESON KO, KLONER RA, BABIOR BM, ENGLER RL, 1994. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest 94:1621-1628.
13. ITO BR, ENGLER RL, DEL BALZO U, 1993. Role of cardiac mast cells in complement C 5a induced myocardial ischemia. Am JPhysiol 33: H1346-H1354.
14. JUNEAU CF, ITO BR, DEL BALZO U, ENGLER RL, 1993. Severe neutrophil depletion by leucocyte filters or cytotoxic drug does not improve recovery of contractile function in stunned porcine myocardium. Cardiovasc Res 27: 720-727.
15. KELLER AM, CLANCY RM, BARR ML, MARBOE CC, CANNON PJ, 1988. Acute reoxygenation injury in the isolated rat heart: role of resident mast cells. Circ Res 63: 1044-1052.
16. KOFSKY ER, JULIA PL, BUCKBERG GD, BUGYI HI, YOUNG H, QUILLEN J, 1988. Effects of neutrophil depletion in limiting reperfusion damage. Surgical Forum 39: 249-254.
17. KUZUYA T, FUJI H, HOSHIDA S, KITABATAKE A, TADA M, 1991. Neutrophil-induced myocardial cell damage and active oxygen metabolites. Jpn Circ 55: 1127-1131.
18. LINDAL S, GUNNES S, YTREHUS K, STRAUME BK, JØRGENSEN L, SØRLIE D, 1990. Amelioration of reperfusion injury following hypothermic, ischemic cardioplegia in isolated, infarcted rat hearts. Eur J Cardiothorac Surg 4: 33-39.
19. LUCCHESI BR, MULLANE KM, 1986. Leukocytes and ischemia-induced myocardial injury. Annu Rev Pharmacol Toxicol 26: 201-224.
20. LUCCHESI BR, WERNS SW, FANTONE JC, 1989. The role of the neutrophil and free radicals in ischemic myocardial injury. J Mol Cell Cardiol 21: 1241-1251.
21. MCDOWELL EM, TRUMP BF, 1986. Histologic fixatives suitable for diagnostic light and electron microscopy. Arch Pathol Lab Med 100: 505-414.
22. MIKI S, ASHRAF M, SALKA S, SPERELAKIS N, 1988. Myocardial dysfunction and ultrastructural alterations mediated by oxygen metabolites. J Mol Cell Cardiol 20: 1009-1024.
23. MULLANE KM, READ N, SALOMON JA, MONCADA S, 1984. Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs. J Pharmacol Exp Ther 228: 510-522.
24. 4. J Vasc Surg 12: 298-304.
25. PARKER CW, 1987. Lipid mediators produced through the lipoxygenase pathway. Annu Rev Immunol 5: 65-84.
26. REIMER KA, LOWE JE, RASSMUSSEN MM, JENNINGS RB, 1977. The wavefront phenomenon of ischemic cell death. I. Myocardial infarct vs duration of coronary occlusion. Circulation 56: 786-794.
27. REIMER KA, MURRY CE, RICHARD VJ, 1989. The role of neutrophils and free radicals in the ischemic-reperfused heart. J Mol Cell Cardiol 21: 1225-1239.
28. REYNOLDS JM, MCDONAGH PF, 1989. Early in reperfusion leukocytes after perfused coronary capillary and vascular resistance. Am J Physiol 256: H982-H989.
29. ROMSON JL, HOOK BG, RIGOT VH, SCHORK MA, SWANSON DP, LUCCHESI BR, 1982. The effect of ibuprofen on accumulation of indium-111-labeled platelets and leukocytes in experimental myocardial infarction. Circulation 66: 1002-1011.
30. ROMSON JL, HOOK BG, KUNKEL SL, ABRAMS GD, SCHORK MA, LUCCHESI BR, 1983. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation 67: 1016-1023.
31. SACKS T, MOLDOW CF, CRADDOCK PR, BOWERS TK, JACOB HS, 1978. Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. J Clin Invest 61: 1161-1167.
32. SAWA Y, SCHARPER J, ROTH M, NAGASAWA K, BALLAGI G, BLEESE N, SCHARPER W, 1994. Platelet-activating factor plays an important role in reperfusion injury in myocardium. J Thorax Cardiovasc Surg 108: 953-958.
33. SCHMID-SCHÖNBEIN GW, ENGLER RL, 1986. Granulocytes as active participants in acute myocardial ischemia and infarction. Am J Cardiovosc Path 1: 15-30.
34. SEMB AG, YTREHUS K, VAAGE J, MYKLEBUST R, MJØS OD, 1989. Functional impairment in isolated rat hearts induced by activated granulocytes: Protective effect of oxygen free radical scavengers. J Mol Cell Cardiol 21: 877-887.
35. SEMB AG, FORSDAHL K, VAAGE J, 1990a. Granulocyte and eicosanoid gradients across the coronary circulation during myocardial reperfusion in cardiac surgery. Eur J Cardiothorac Surg 4: 543-548.
36. SEMB AG, VAAGE J, MJØS OD, 1990b. Oxygen free radical producing leukocytes cause functional depression of isolated rat hearts: role of leukotrienes. J Mol Cell Cardiol 22: 555-563.
37. SEMB AG, GABRIELSEN TO, HALSTENSEN TS, FAGERHOL MK, BRANDTZAEG P, VAAGE J, 1991. Cardiac surgery and distribution of the leukocyte L1 protein-calprotectin. Eur J Cardiothorac Surg 5: 363-367.
38. SEMB AG, VAAGE J, 1991. Oxygen free radical-induced injury in isolated rat hearts: effects of ibuprofen and BW 755c. Scand J Clin Lab Invest 51: 377-384.
39. SHANDELYA S, KUPPUSAMY P, WEISFELDT M, ZWEIER J, 1993. Evaluation of the role of polymorphonuclear leukocytes on contractile function in myocardial reperfusion injury. Evidence for plasma-mediated leucocyte activation. Circulation 87: 536-546.
40. SOMMERS HM, JENNINGS RB, 1964. Experimental acute myocardial infarction. Histologic and histochemical studies of early infarcts induced by temporary or permanent occlusion of a coronary artery. Lab Invest 13: 1491-1503.
41. TANAKA M, BROOKS S, RICHARD V, FITZHARRIS G, STOLER R, 1993. Effect of anti-CD18 antibody on myocardial neutrophil accumulation and infarct size after ischemia and reperfusion in dogs. Circulation 87: 526-535.
42. TIPPINS JR, ANTONIW JW, ALISON MR, GARVEY B, MASERI A, 1992. WEB 2086 inhibits neutrophil dependent increases in coronary resistance in blood perfused rabbit heart. Cardiovasc Res 26: 162-169.
43. WEIBEL ER, BOLENDER RP, 1973. Stereological techniques for electron microscopic morphometry. In: Hayat MA ed. Principle and Techniques of Electron Microscopy. Vol. 3, Van Nostrand Reinhold Company. 237-96.
44. WHATLEY RE, ZIMMERMAN GA, MCINTYRE TM, PRESCOTT SM, 1990. Lipid metabolism and signal transduction in endothelial cells. Prog Lipid Res 29: 45-63.
45. WEGLICKI WB, LOW MG, 1987. Phospholipases of the myocardium. Basic Res Cardiol 82: Suppl 1, 107-112.
46. YTREHUS K, MYKLEBUST R, OLSEN R, MJØS O, 1987. Ultrastructural changes induced in the isolated rat heart by enzymatically generated oxygen radicals. J Mol Cell Cardiol 19: 379-389.
47. YTREHUS K, RINGSTAD J, MYKLEBUST R, NORHEIM G, MJØS OD, 1988. The selenium-deficient rat heart with special reference to tolerance against enzymatically generated oxygen radicals. Scand J Clin Lab Invest 48: 289-295.
48. YTREHUS K, ROTEVATN S, LØVAAS E, SAETERSDAL T, MJØS OD, 1989. Mitochondrial calcium in hearts subjected to lipid peroxidation with contracture development. Basic Res Cardiol 84: 646-652.
49. YTREHUS K, WALSH RS, RICHARDS SC, DOWNEY JM, Hydrogen peroxide as a protective agent during reperfusion: a study in the isolated perfused rabbit heart subjected to regional ischaemia. Cardiovasc Res, in press.