Pharmacologic evaluation of the discriminative stimulus of metachlorophenylpiperazine

Pharmacology Biochemistry and Behavior

Volumn 53, Issue 1, 1996, Pages 107-114

  Bourson, Anne ^a   Wanner, Daniel ^a   Wyler, Roger ^a   Petit, Nadine ^a   Zwingelstein, Catherine ^a   Rudler, Alain ^a   Sleight, Andrew J ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

5 HT receptors; 5 HT(2C) receptor; Dopamine neurotransmission; Drug discrimination; mCPP; PI turnover

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1 (1 METHYL 5 INDOLYL) 3 (3 PYRIDYL)UREA; 1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 METHOXY 3 (1,2,3,6 TETRAHYDRO 4 PYRIDYL) 1H INDOLE; 6 CHLORO 2 (1 PIPERAZINYL)PYRAZINE; AMPHETAMINE; APOMORPHINE; BEMESETRON; FENFLURAMINE; HALOPERIDOL; INOSITOL TRISPHOSPHATE; MESULERGINE; METITEPINE; MIANSERIN; PINDOLOL; POSTSYNAPTIC RECEPTOR; RECEPTOR SUBTYPE; RITANSERIN; SEROTONIN; SEROTONIN 3 ANTAGONIST; SEROTONIN RECEPTOR; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOROID PLEXUS; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DOPAMINERGIC TRANSMISSION; DRUG ANTAGONISM; DRUG DISCRIMINATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RAT; STIMULUS GENERALIZATION; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029879859     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)00207-3     Document Type: Article

References (24)

1. Argiolas, A,; Melis, M. R.; Gessa, G. L. Yawning and penile erection: Central dopamine-oxytocin-adrenocorticotrophin connection. Ann. NY Acad. Science 525:330-337; 1988.
2. 1C receptors in drug-induced penile erections in rats. Psychopharmacology 101:57-61; 1990.
3. Bourson, A.; Gower, A. J.; Mir, A. K.; Moser, P. C. The effects of dihydropyridine compounds in behavioural tests of dopaminergic activity. Br. J. Pharmacol. 312:318; 1989.
4. Bourson, A.; Moser, P. C. Yawning induced by apomorphine, physostigmine or pilocarpine is potentiated by dihydropyridine calcium channel blockers. Psychopharmacology 100:168-172; 1990.
5. Bourson, A.; Wanner, D.; Wyler, R.; Sleight, A. J. A pharmacological study of the MCPP discriminative stimulus. Br. J. Pharmacol. 112:304P; 1994.
6. 2C receptors mediating the discriminative stimulus properties of m-chlorophenylpiperazine (mCPP). Eur. J. Pharmacol. 257:27-38; 1994.
7. 3H]Mesulergine, a selective ligand for serotonin-2 receptors. Life Sci. 32:2485-2495; 1983.
8. 1C) receptors. J. Pharmacol. Exp. Ther. 242:552-557; 1987.
9. Conn, P. J.; Sanders-Bush, E.; Hoffman, B. J.; Hartig, P. R. A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover. Proc. Natl. Acad. Sci. USA 83:4086-4088; 1986.
10. Dworkin, S. I.; Bimle, C. 6-Hydroxydopamine lesions of the nucleus accumbens attenuate the discriminative stimulus effects of D-amphetamine. Drug Dev. Res. 16:435-441; 1989.
11. Ferrer, A.; Artigas, F. Effects of single and chronic teatment with tranylcypromine on extracellular serotonin in rat brain. Eur. J. Pharmacol. 263:227-234; 1994.
12. 1C receptor antagonist. J. Med. Chem. 36: 1104-1107; 1993.
13. Gower, A. G.; Berendsen, H. H. G.; Princen, M. M.; Broekkamp, C. L. E. The yawning-penile erection syndrome as a model for putative dopamine autoreceptor activity. Eur. J. Pharmacol. 103:81-89; 1984.
14. Hamik, A.; Peroutka, S. J. 1-(m-chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain. Biol. Psychiatry 25:569-575; 1989.
15. 3H]ketanserin. Eur. J. Pharmacol. 118:13-23; 1985.
16. Kahn, R. S.; Wetzler, S. m-Chlorophenylpiperazine as a probe for serotonin function. Biol. Psychiatry 30:1139-1166; 1991.
17. 1C receptors and their therapeutic relevance. Curr. Opin. Invest. Drugs 2:317-362; 1993.
18. 2C/2B receptor antagonist. Br. J. Pharmacol. 111:797-802; 1994.
19. 1C receptors. Neurosci. Biobehav. Rev. 16:95-105; 1992.
20. Nielsen, E. B.; Scheel-Kruger, J. Cueing effects of amphetamine and LSD: Elicitation by direct microinjection of the drugs into the nucleus accumbens. Eur. J. Pharmacol. 125:85-92; 1986.
21. 3 receptors. Life Sci. 50:599-605; 1992.
22. Tricklebank, M. D.; Singh, L.; Oles, R. J.; Wong, E. H. F.; Iversen, S. D. A role for receptors of N-methyl-D-aspartic acid in the discriminative stimulus properties of phencyclidine. Eur. J. Pharmacol. 141:497-501; 1987.
23. Willets, J.; Balster, R. L. The discriminative stimulus effects of N-methyl-D-aspartate antagonists in phencyclidine-trained rats. Neuropharmacology 27:1249-1256; 1988.
24. Winter, J. C.; Rabin, R. A. Discriminative stimulus properties of m-chlorophenylpiperazine. Pharmacol. Biochem. Behav. 45:221-223; 1993.