-
1
-
-
0025817404
-
Past, present and future of hirudin
-
Markwardt F. Past, present and future of hirudin. Haemostasis 1991; 21 Suppl. 1: 11-26
-
(1991)
Haemostasis
, vol.21
, Issue.1 SUPPL.
, pp. 11-26
-
-
Markwardt, F.1
-
2
-
-
0014084702
-
Die isolierung des hirudins aus medizinischen blutegeln
-
Markwardt F, Schäfer G, Töpfer H, et al. Die isolierung des hirudins aus medizinischen blutegeln [in German]. Pharmazie 1967; 22: 239-41
-
(1967)
Pharmazie
, vol.22
, pp. 239-241
-
-
Markwardt, F.1
Schäfer, G.2
Töpfer, H.3
-
3
-
-
0000935703
-
Large-scale preparation of hirudin
-
Bagdy D, Barabas E, Graf L. Large-scale preparation of hirudin. Thromb Res 1973; 2: 229-38
-
(1973)
Thromb Res
, vol.2
, pp. 229-238
-
-
Bagdy, D.1
Barabas, E.2
Graf, L.3
-
4
-
-
0020540075
-
Hirudin from leech heads and whole leeches and 'pseudo-hirudin' from leech bodies
-
Baskova IP, Cherkesova DU, Mosolov VV. Hirudin from leech heads and whole leeches and 'pseudo-hirudin' from leech bodies. Thromb Res 1983; 30: 459-67
-
(1983)
Thromb Res
, vol.30
, pp. 459-467
-
-
Baskova, I.P.1
Cherkesova, D.U.2
Mosolov, V.V.3
-
5
-
-
0024146749
-
Hirudins and the role of thrombin: Lessons from leeches
-
Wallis RB. Hirudins and the role of thrombin: lessons from leeches. Trends Pharmacol Sci 1988; 9: 425-7
-
(1988)
Trends Pharmacol Sci
, vol.9
, pp. 425-427
-
-
Wallis, R.B.1
-
6
-
-
0025087055
-
The pharmacology of recombinant hirudin, a new anticoagulant
-
Meyer BH, Luus HG, Müller FO, et al. The pharmacology of recombinant hirudin, a new anticoagulant. S Afr Med J 1990; 78: 268-70
-
(1990)
S Afr Med J
, vol.78
, pp. 268-270
-
-
Meyer, B.H.1
Luus, H.G.2
Müller, F.O.3
-
7
-
-
0025346345
-
Design and characterization of hirulogs: A novel class of bivalent peptide inhibitors of thrombin
-
Maraganore JM, Bourdon P, Jablonski J, et al. Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin. Biochemistry 1990; 29: 7095-101
-
(1990)
Biochemistry
, vol.29
, pp. 7095-7101
-
-
Maraganore, J.M.1
Bourdon, P.2
Jablonski, J.3
-
8
-
-
0025899470
-
Hirudin and derivatives as anticoagulant agents
-
Markwardt F. Hirudin and derivatives as anticoagulant agents. Thromb Haemost 1991; 66: 141-52
-
(1991)
Thromb Haemost
, vol.66
, pp. 141-152
-
-
Markwardt, F.1
-
10
-
-
0026639940
-
Hirudins: Return of the leech?
-
Editorial. Hirudins: return of the leech? Lancet 1992; 340: 579-80
-
(1992)
Lancet
, vol.340
, pp. 579-580
-
-
-
11
-
-
0024457599
-
Binding of thrombin to subendothelial extracellular matrix: Protection and expression of functional properties
-
Bar-Shavit R, Eldora A, Vlodavsky I. Binding of thrombin to subendothelial extracellular matrix: protection and expression of functional properties. J Clin Invest 1989; 84: 1096-104
-
(1989)
J Clin Invest
, vol.84
, pp. 1096-1104
-
-
Bar-Shavit, R.1
Eldora, A.2
Vlodavsky, I.3
-
12
-
-
0026595286
-
Hirudins: Antithrombin anticoagulants
-
Stringer KA, Lindenfeld J. Hirudins: antithrombin anticoagulants. Ann Pharmacother 1992; 26: 1535-40
-
(1992)
Ann Pharmacother
, vol.26
, pp. 1535-1540
-
-
Stringer, K.A.1
Lindenfeld, J.2
-
13
-
-
0024416485
-
Development of hirudin as an antithrombotic agent
-
Marckwardt F. Development of hirudin as an antithrombotic agent. Semin Thromb Haemost 1989; 15: 269-82
-
(1989)
Semin Thromb Haemost
, vol.15
, pp. 269-282
-
-
Marckwardt, F.1
-
14
-
-
0027257780
-
Clinical pharmacology of intravenously administered recombinant desulfatohirudin (CGP 39393) in healthy volunteers
-
Marbet GA, Verstraete M, Kienast J, et al. Clinical pharmacology of intravenously administered recombinant desulfatohirudin (CGP 39393) in healthy volunteers. J Cardiovasc Pharm 1993; 22: 364-72
-
(1993)
J Cardiovasc Pharm
, vol.22
, pp. 364-372
-
-
Marbet, G.A.1
Verstraete, M.2
Kienast, J.3
-
15
-
-
0027358905
-
Biologic effects of recombinant hirudin (CGP 39393) in human volunteers
-
Verstraete M, Nurmohamed M, Kienast J, et al. Biologic effects of recombinant hirudin (CGP 39393) in human volunteers. J Am Coll Cardiol 1993; 22: 1080-8
-
(1993)
J Am Coll Cardiol
, vol.22
, pp. 1080-1088
-
-
Verstraete, M.1
Nurmohamed, M.2
Kienast, J.3
-
16
-
-
0027932365
-
Direct thrombin inhibitors in cardiovascular medicine
-
Lefkovits J, Topol EJ. Direct thrombin inhibitors in cardiovascular medicine. Circulation 1994; 90: 1522-36
-
(1994)
Circulation
, vol.90
, pp. 1522-1536
-
-
Lefkovits, J.1
Topol, E.J.2
-
18
-
-
0028891769
-
Antithrombotic therapy. An abbreviated reference for clinicians
-
Becker RC, Ansell J. Antithrombotic therapy. An abbreviated reference for clinicians. Arch Intern Med 1995; 155: 149-61
-
(1995)
Arch Intern Med
, vol.155
, pp. 149-161
-
-
Becker, R.C.1
Ansell, J.2
-
19
-
-
0027964241
-
Direct thrombin inhibition with rec-hirudin CGP 39393 as prophylaxis of thromboembolic complications after total hip replacement
-
Eriksson BI, Kälebo P, Ekman S, et al. Direct thrombin inhibition with rec-hirudin CGP 39393 as prophylaxis of thromboembolic complications after total hip replacement. Thromb Haemost 1994; 72 (2): 227-31
-
(1994)
Thromb Haemost
, vol.72
, Issue.2
, pp. 227-231
-
-
Eriksson, B.I.1
Kälebo, P.2
Ekman, S.3
-
20
-
-
0027985641
-
Use of hirulog in the prevention of venous thrombosis after major hip or knee surgery
-
Ginsberg JS, Nurmohamed MT, Gent M, et al. Use of hirulog in the prevention of venous thrombosis after major hip or knee surgery. Circulation 1994; 90: 2385-9
-
(1994)
Circulation
, vol.90
, pp. 2385-2389
-
-
Ginsberg, J.S.1
Nurmohamed, M.T.2
Gent, M.3
-
21
-
-
1842415639
-
™Revasc-Ciba), in patients undergoing total hip replacement
-
™Revasc-Ciba), in patients undergoing total hip replacement [abstract]. Thromb Haemost 1995; 73: 1108
-
(1995)
Thromb Haemost
, vol.73
, pp. 1108
-
-
Eriksson, B.I.1
Kälebo, P.2
Ekman, S.3
-
22
-
-
4243791923
-
™Revasc-Ciba), is the most effective and safe prophylaxis of thromboembolic complications in patients undergoing total hip replacement
-
™Revasc-Ciba), is the most effective and safe prophylaxis of thromboembolic complications in patients undergoing total hip replacement [abstract]. Thromb Haemost 1995; 73: 1093
-
(1995)
Thromb Haemost
, vol.73
, pp. 1093
-
-
Ekman, S.1
Eriksson, B.I.2
Lindbratt, S.3
-
23
-
-
0023275245
-
Adjusted subcutaneous heparin or continuous intravenous heparin in patients with acute deep vein thrombosis
-
Doyle DJ, Turpie AGG, Hirsh J, et al. Adjusted subcutaneous heparin or continuous intravenous heparin in patients with acute deep vein thrombosis. Ann Intern Med 1987; 107: 441-5
-
(1987)
Ann Intern Med
, vol.107
, pp. 441-445
-
-
Doyle, D.J.1
Turpie, A.G.G.2
Hirsh, J.3
-
24
-
-
0028109313
-
Recurrent pulmonary embolism in patients treated because of acute venous thromboembolism: A prospective study
-
Monreal M, Lafoz E, Ruiz J, et al. Recurrent pulmonary embolism in patients treated because of acute venous thromboembolism: a prospective study. Eur J Vasc Surg 1994; 8: 584-9
-
(1994)
Eur J Vasc Surg
, vol.8
, pp. 584-589
-
-
Monreal, M.1
Lafoz, E.2
Ruiz, J.3
-
25
-
-
0026576068
-
Subcutaneous low-molecular-weight heparin compared with continuous intravenous heparin in the treatment of proximal-vein thrombosis
-
Hull RD, Raskob GE, Pineo GF, et al. Subcutaneous low-molecular-weight heparin compared with continuous intravenous heparin in the treatment of proximal-vein thrombosis. N Engl J Med 1992; 326: 975-82
-
(1992)
N Engl J Med
, vol.326
, pp. 975-982
-
-
Hull, R.D.1
Raskob, G.E.2
Pineo, G.F.3
-
26
-
-
0027293280
-
Treatment of severe venous thrombo-embolism with intravenous hirudin (HBW 023): An open pilot study
-
Parent F, Bridey F, Dreyfus M, et al. Treatment of severe venous thrombo-embolism with intravenous hirudin (HBW 023): an open pilot study. Thromb Haemost 1993; 70 (3): 386-8
-
(1993)
Thromb Haemost
, vol.70
, Issue.3
, pp. 386-388
-
-
Parent, F.1
Bridey, F.2
Dreyfus, M.3
-
27
-
-
0028273524
-
A pilot study of subcutaneous recombinant hirudin (HBW 023) in the treatment of deep vein thrombosis
-
Schiele F, Vuillemenot A, Kramarz PH, et al. A pilot study of subcutaneous recombinant hirudin (HBW 023) in the treatment of deep vein thrombosis. Thromb Haemost 1994; 71 (5): 558-62
-
(1994)
Thromb Haemost
, vol.71
, Issue.5
, pp. 558-562
-
-
Schiele, F.1
Vuillemenot, A.2
Kramarz, P.H.3
-
29
-
-
0001486154
-
Treatment of acute deep vein thrombosis (DVT) by subcutaneous r-hirudin (HBW 023): A multicentre study
-
Moia M, Schiele F, Walker M, et al. Treatment of acute deep vein thrombosis (DVT) by subcutaneous r-hirudin (HBW 023): a multicentre study [abstract]. Thromb Haemost 1995; 73: 1456
-
(1995)
Thromb Haemost
, vol.73
, pp. 1456
-
-
Moia, M.1
Schiele, F.2
Walker, M.3
-
30
-
-
0026736119
-
Reactivation of unstable angina after the discontinuation of heparin
-
Théroux P, Waters D, Lam J, et al. Reactivation of unstable angina after the discontinuation of heparin. N Engl J Med 1992; 327: 141-5
-
(1992)
N Engl J Med
, vol.327
, pp. 141-145
-
-
Théroux, P.1
Waters, D.2
Lam, J.3
-
31
-
-
0027140468
-
Usefulness and tolerability of hirulog, a direct thrombin-inhibitor, in unstable angina pectoris
-
Sharma GVRK, Lapsley D, Vita JA, et al. Usefulness and tolerability of hirulog, a direct thrombin-inhibitor, in unstable angina pectoris. Am J Cardiol 1993; 72: 1357-60
-
(1993)
Am J Cardiol
, vol.72
, pp. 1357-1360
-
-
Sharma, G.V.R.K.1
Lapsley, D.2
Vita, J.A.3
-
32
-
-
0027497137
-
Initial experience with a direct antithrombin, hirulog, in unstable angina. Anticoagulant, antithrombotic, and clinical effects
-
Lidón RM, Théroux P, Juneau M, et al. Initial experience with a direct antithrombin, hirulog, in unstable angina. Anticoagulant, antithrombotic, and clinical effects. Circulation 1993; 88 (Pt 1): 1495-501
-
(1993)
Circulation
, vol.88
, Issue.1 PART
, pp. 1495-1501
-
-
Lidón, R.M.1
Théroux, P.2
Juneau, M.3
-
33
-
-
0028346249
-
Recombinant hirudin for unstable angina pectoris. A multicenter, randomized angiographic trial
-
Topol EJ, Fuster V, Harrington RA, et al. Recombinant hirudin for unstable angina pectoris. A multicenter, randomized angiographic trial. Circulation 1994; 89: 1557-66
-
(1994)
Circulation
, vol.89
, pp. 1557-1566
-
-
Topol, E.J.1
Fuster, V.2
Harrington, R.A.3
-
34
-
-
0026474084
-
Randomized trial of thrombolysis versus heparin in unstable angina
-
Schreiber TL, Rizik D, White C, et al. Randomized trial of thrombolysis versus heparin in unstable angina. Circulation 1992; 86: 1407-14
-
(1992)
Circulation
, vol.86
, pp. 1407-1414
-
-
Schreiber, T.L.1
Rizik, D.2
White, C.3
-
35
-
-
0023754429
-
Aspirin, heparin, or both to treat acute unstable angina
-
Théroux P, Ouimet H, McCans J, et al. Aspirin, heparin, or both to treat acute unstable angina. N Engl J Med 1988; 319: 1105-11
-
(1988)
N Engl J Med
, vol.319
, pp. 1105-1111
-
-
Théroux, P.1
Ouimet, H.2
McCans, J.3
-
36
-
-
0018760094
-
Nonoperative dilation of coronary artery stenosis: Percutaneous transluminal coronary angioplasty
-
Gruentzig AR, Senning A, Siegenthaler WE. Nonoperative dilation of coronary artery stenosis: percutaneous transluminal coronary angioplasty. N Engl J Med 1979; 301: 61-71
-
(1979)
N Engl J Med
, vol.301
, pp. 61-71
-
-
Gruentzig, A.R.1
Senning, A.2
Siegenthaler, W.E.3
-
37
-
-
0027209030
-
Effect of a direct antithrombin, hirulog, in place of heparin during coronary angioplasty
-
Topol EJ, Bonan R, Jewitt D, et al. Effect of a direct antithrombin, hirulog, in place of heparin during coronary angioplasty. Circulation 1993; 87: 1622-9
-
(1993)
Circulation
, vol.87
, pp. 1622-1629
-
-
Topol, E.J.1
Bonan, R.2
Jewitt, D.3
-
38
-
-
0027496925
-
Safety and efficacy of recombinant hirudin (CGP 39393) versus heparin in patients with stable angina undergoing coronary angioplasty
-
van den Bos AA, Deckers JW, Heyndrickx GR, et al. Safety and efficacy of recombinant hirudin (CGP 39393) versus heparin in patients with stable angina undergoing coronary angioplasty. Circulation 1993; 88 (Pt 1): 2058-66
-
(1993)
Circulation
, vol.88
, Issue.1 PART
, pp. 2058-2066
-
-
Van Den Bos, A.A.1
Deckers, J.W.2
Heyndrickx, G.R.3
-
39
-
-
0029101260
-
A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty
-
Serruys PW, Herrman JPR, Simon R, et al. A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty. N Engl J Med 1995; 333: 757-63
-
(1995)
N Engl J Med
, vol.333
, pp. 757-763
-
-
Serruys, P.W.1
Herrman, J.P.R.2
Simon, R.3
-
40
-
-
0029103184
-
Treatment with Bivalirudin (hirulog) as compared with heparin during coronary angioplasty for unstable or postinfarction angina
-
Bittl JA, Strony J, Brinker JA, et al. Treatment with Bivalirudin (hirulog) as compared with heparin during coronary angioplasty for unstable or postinfarction angina. N Engl J Med 1995; 333: 764-9
-
(1995)
N Engl J Med
, vol.333
, pp. 764-769
-
-
Bittl, J.A.1
Strony, J.2
Brinker, J.A.3
-
41
-
-
0027240597
-
An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction
-
The GUSTO investigators. An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med 1993; 329: 673-82
-
(1993)
N Engl J Med
, vol.329
, pp. 673-682
-
-
-
42
-
-
0024514359
-
Comparison of invasive and conservative strategies after treatment with intravenous tissue plasminogen activator in acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI) phase II trial
-
TIMI Study Group. Comparison of invasive and conservative strategies after treatment with intravenous tissue plasminogen activator in acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI) phase II trial. N Engl J Med 1989; 320: 618-27
-
(1989)
N Engl J Med
, vol.320
, pp. 618-627
-
-
-
43
-
-
0001795967
-
Pathogenesis of thrombosis
-
Williams WJ, Beutler E, Erslev AJ, Lichtman MA, editors. New York: McGraw-Hill
-
Harker LA. Pathogenesis of thrombosis. In: Williams WJ, Beutler E, Erslev AJ, Lichtman MA, editors. Hematology. 4th ed. New York: McGraw-Hill, 1990: 1559-69
-
(1990)
Hematology. 4th Ed.
, pp. 1559-1569
-
-
Harker, L.A.1
-
44
-
-
0028296374
-
A pilot trial of recombinanl desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) 5 Trial
-
Cannon CP, McCabe CH, Henry TD, et al. A pilot trial of recombinanl desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 5 Trial. J Am Coll Cardiol 1994; 23: 993-1003
-
(1994)
J Am Coll Cardiol
, vol.23
, pp. 993-1003
-
-
Cannon, C.P.1
McCabe, C.H.2
Henry, T.D.3
-
45
-
-
0028795568
-
Initial experience with hirudin and streptokinase in acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) 6 Trial
-
Lee LV, for the TIMI 6 investigators. Initial experience with hirudin and streptokinase in acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 6 Trial. Am J Cardiol 1995; 75: 7-13
-
(1995)
Am J Cardiol
, vol.75
, pp. 7-13
-
-
Lee, L.V.1
-
46
-
-
0028092111
-
Hirudin in acute myocardial infarction. Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9 Trial
-
Antman EM, for the TIMI 9 investigators. Hirudin in acute myocardial infarction. Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9 Trial. Circulation 1994; 90: 1624-30
-
(1994)
Circulation
, vol.90
, pp. 1624-1630
-
-
Antman, E.M.1
-
47
-
-
0028037517
-
Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes
-
The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) Ila Investigators. Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. Circulation 1994; 90: 1631-7
-
(1994)
Circulation
, vol.90
, pp. 1631-1637
-
-
-
48
-
-
0028117846
-
Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT-III) Study. A study of the Arbeitsgemeinschaft leitender kardiologischer krankenhausärzte (ALKK)
-
Neuhaus KL, Essen RV, Tebbe U, et al. Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT-III) Study. A study of the Arbeitsgemeinschaft leitender kardiologischer krankenhausärzte (ALKK). Circulation 1994; 90: 1638-42
-
(1994)
Circulation
, vol.90
, pp. 1638-1642
-
-
Neuhaus, K.L.1
Essen, R.V.2
Tebbe, U.3
-
49
-
-
0028326748
-
A pilot, early angiographic patency study using a direct thrombin inhibitor as adjunctive therapy to streptokinase in acute myocardial infarction
-
Lidón RM, Théroux P, Lespérance J, et al. A pilot, early angiographic patency study using a direct thrombin inhibitor as adjunctive therapy to streptokinase in acute myocardial infarction. Circulation 1994; 89: 1567-72
-
(1994)
Circulation
, vol.89
, pp. 1567-1572
-
-
Lidón, R.M.1
Théroux, P.2
Lespérance, J.3
-
50
-
-
0028936602
-
Randomized double-blind comparison of two doses of hirulog with heparin as adjunctive therapy to streptokinase to promote early patency of the infarct-related artery in acute myocardial infarction
-
Théroux P, Pérez-Villa F, Waters D, et al. Randomized double-blind comparison of two doses of hirulog with heparin as adjunctive therapy to streptokinase to promote early patency of the infarct-related artery in acute myocardial infarction. Circulation 1995; 91: 2132-9
-
(1995)
Circulation
, vol.91
, pp. 2132-2139
-
-
Théroux, P.1
Pérez-Villa, F.2
Waters, D.3
-
51
-
-
0027258015
-
Effects of hirudin on activated partial thromboplastin time determined with ten different reagents
-
Tripodi A, Chantarangkul V, Arbini AA, et al. Effects of hirudin on activated partial thromboplastin time determined with ten different reagents. Thromb Haemost 1993; 70: 286-8
-
(1993)
Thromb Haemost
, vol.70
, pp. 286-288
-
-
Tripodi, A.1
Chantarangkul, V.2
Arbini, A.A.3
-
52
-
-
0028895451
-
Effects of two different doses of hirudin on aPTT, determined with eight different reagents
-
Monreal M, Monreal L, Ruiz de Gopegui R, et al. Effects of two different doses of hirudin on aPTT, determined with eight different reagents. Thromb Haemost 1995; 73: 219-22
-
(1995)
Thromb Haemost
, vol.73
, pp. 219-222
-
-
Monreal, M.1
Monreal, L.2
Ruiz De Gopegui, R.3
|