Spread of murine cytomegalovirus to inner ocular structures following disruption of the blood-retina barrier in immunosuppressed BALB/c mice

Investigative Ophthalmology and Visual Science

Volumn 37, Issue 5, 1996, Pages 935-940

  Duan, Yanping ^a   Hemandez, Roy ^a   Pang, Ling ^a   Atherton, Sally S ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

BALB c mouse; blood retina barrier; cytomegalovirus; immunosuppression; virus infection

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD RETINA BARRIER; CONTROLLED STUDY; CYTOMEGALOVIRUS; FEMALE; IMMUNE DEFICIENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS CONCENTRATION; VIRUS CULTURE; VIRUS INFECTION;

ANIMALS; ANTERIOR EYE SEGMENT; ANTI-INFLAMMATORY AGENTS; BETA-GALACTOSIDASE; BLOOD-RETINAL BARRIER; EYE INFECTIONS, VIRAL; FEMALE; HERPESVIRIDAE INFECTIONS; IMMUNOSUPPRESSION; LACRIMAL APPARATUS; METHYLPREDNISOLONE; MICE; MICE, INBRED BALB C; MUROMEGALOVIRUS; RETINA; SCLERA;

EID: 0029879851     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Drew WL. Cytomegalovirus infection in patients with AIDS. Clin Infect Dis. 1992;14:608-615.
2. Bale JE, O'Neil ME, Hogan RN, Kern ER. Experimental murine Cytomegalovirus infection of ocular tissues. Arch Ophthalmol. 1984;102:1214-1219.
3. Atherton SS, Newell CK, Kanter MY, Cousins SW. T cell depletion increases susceptibility to MCMV retinitis. Invest Ophthalmol Vis Sci. 1992;33:3353-3360.
4. Pomerantz RJ, Kuritzkes DR, de la Monte SM, et al. Infection of the retina by human immunodeficiency virus type 1. New Engl J Med. 1987;317:1643-1647.
5. Faber DW, Wiley CA, Lynn GB, Gross JG, Freeman WR. Role of HIV and CMV in the pathogenesis of retinitis and retinal vasculopathy in AIDS patients. Invest Ophtkalmol Vis Sci. 1992;33:2345-2353.
6. Qavi HB, Green MT, SeGall GK, Lewis DE, Hollinger FB. Transcriptional activity of HIV-1 and HHV-6 in retinal lesions from AIDS patients. Invest Ophthalmol Vis Sci. 1992;33:2759-2767.
7. Gao E-K, Yu X-H, Lin C-P, Zhang H, Kaplan HJ. Intraocular viral replication after systemic murine cytomegalovirus infection requires immunosuppression. Invest Ophthalmol Vis Sci. 1995;36:2322-2327.
8. Stoddart CA, Cardin RD, Boname JM, Manning WC, Abenes GB, Mocarski ES. Peripheral blood mononuclear phagocytes mediate dissemination of murine cytomegalovirus. J Virol. 1994;68:6243-6253.
9. Atherton SS, Newell CK, Kanter MY, Cousins SW. Retinitis in euthymic mice following inoculation of murine cytomegalovirus (MCMV) via the supraciliary route. Curr Eye Res. 1991;10:667-677.
10. Bale JF Jr, O'Neil ME, Lyon B, Perlman S. The pathogenesis of murine cytomegalovirus ocular infection: Anterior chamber inoculation. Invest Ophthalmol Vis Sci. 1990;31:1575-1581.
11. Holland GN, Fang EN, Glasgow BJ, et al. Necrotizing retinopathy after intraocular inoculation of murine cytomegalovirus in immunosuppressed adult mice. Invest Ophthalmol Vis Sci. 1990;31:2326-2334.
12. Bale JF Jr, O'Neil ME. Detection of murine cytomegalovirus DNA in circulating leukocytes harvested during acute infection of mice. J Virol. 1989;63:2667-2673.
13. Grefte A, Harmsen MG, van der Giessen M, Knollema S, van Son WJ, The TH. Presence of human cytomegalovirus (HCMV) immediate early mRNA but no ppUL83 (lower matrix protein pp65) mRNA in polymorphonuclear and mononuclear leukocytes during active HCMV infection. J Gen Virol. 1994;75:1989-1998.
14. Duan Y, Ji Z, Atherton SS. Dissemination and replication of MCMV after supraciliary inoculation in immunosuppressed BALB/c mice. Invest Ophthalmol Vis Sci. 1994;35:1124-1131.