Effect of ELAD liver support on plasma HGF and TGF-β1 in acute liver failure

International Journal of Artificial Organs

Volumn 19, Issue 4, 1996, Pages 240-244

  Miwa, Y ^a   Ellis, A J ^a   Hughes, R D ^a   Langley, P G ^a   Wendon, J A ^a   Williams, R ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Bioartificial liver; Hepatocyte growth factor; Liver failure; Transforming growth factor 1

Indexed keywords

ARTIFICIAL ORGANS; PATIENT TREATMENT;

ACUTE LIVER FAILURE; BIOARTIFICIAL LIVER; GROWTH FACTOR; HEPATOCYTE GROWTH FACTOR; INITIAL PLASMAS; LIVER ASSIST DEVICE; LIVER FAILURE; LIVER REGENERATION; TRANSFORMING GROWTH FACTOR-Β1; TRANSFORMING GROWTH FACTORS;

POLYSACCHARIDES;

HEPARIN; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UNIHEP;

ADULT; ARTICLE; ARTIFICIAL LIVER; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; LIVER FAILURE; MALE; THROMBOSIS;

EID: 0029879488     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139889601900406     Document Type: Article

References (17)

1. Lin T, Lee C, Chen G, Liau K, Lin W. Regeneration of human liver after hepatic lobectomy studied by repeated liver scanning and repeated needle biopsy. Ann Surg 1979; 190: 48-53.
2. Michalopoulos GK. Liver regeneration: molecular mechanism of growth control. FASEB J 1990; 4: 176-87.
3. Rakela J, Lange S, Ludwig J, Baldus W. Fulminant hepatitis: Mayo Clinic experience with 34 cases. Mayo Clin Proc 1985; 60: 289-92.
4. Sussman NL, Chong MG, Koussayer T, et al Reversal of fulminant hepatic failure using an extracorporeal liver assist device. Hepatology 1992; 16: 60-5.
5. Strain A, Ismail T, Tsubouchi H, et al. Native and recombinant human hepatocyte growth factors are highly potent promoters of DNA synthesis in both human and rat hepatocytes. J Clin Invest 1991; 87: 1853-7.
6. Nakamura T, Tomita Y, Hirai R, Yamaoka K, Kaji K, Ichihara A. Inhibitory effect of transforming growth factor β on DNA synthesis of adult rat hepatocytes in primary culture. Biochem Biophy Res Commun 1985; 133: 1042-50.
7. Russel WE, Coffey RJ, Ouellette AJ, Moses HL. Type β transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat. Proc Natl Acad Sci 1988; 85: 5126-30.
8. Tsubouchi H, Niitani Y, Hirono S, et al. Levels of the human hepatocyte growth factor in serum of patients with various liver diseases determined by an enzyme-linked immunosorbent assay. Hepatology 1991; 15: 1-5.
9. Tomiya T, Nagoshi S, Fujiwara K. Significance of serum human hepatocyte growth factor in patients with hepatic failure. Hepatology 1991; 15: 1-4.
10. Naka D, Ishii T, Shimomura T, Hishida T, Hara H. Heparin modulates the receptor-binding and mitogenic activity of hepatocyte growth factor on hepatocyte. Exp Cell Res 1993; 209: 317-24
11. Pernambuco J, Hughes R, Langley P, Izumi S, Williams R. Hepatocyte growth factor and plasminogen activation in fulminant hepatic failure. Blood Coag Fibrinol 1994; 5: 511-5.
12. Kato Y, Liu K-X, Nakamura T, Sugiyama Y. Heparinhepatocyte growth factor complex with low plasma clearance and retained hepatocyte proliferating activity. Hepatology 1994; 20: 417-24.
13. Hughes RD, Zhang L, Tsubouchi H, Daikuhara Y, Williams R. Plasma hepatocyte growth factor and biliprotein levels and outcome in fulminant hepatic failure. J Hepatol 1994; 20: 106-11.
14. Ishii T, Sano M, Sudo K, et al. Hepatocyte growth factor stimulates liver regeneration and elevates blood protein level in normal and partially hepatectomized rats J Biochem 1995; 117: 1105-12.
15. Gazzard B, Clark R, Borirakchanyavat V, Williams R. A controlled trial of heparin therapy in the coagulation defect of paracetamol-induced hepatic necrosis. Gut 1974; 15: 89-93.
16. 2-microglobulin plasma levels. Kidney Int 1991; 40 1110-7.
17. Zvibel I, Halay E, Reid L. Heparin and hormonal regulation on mRNA synthesis and abundance of autocrine growth factors: relevance to clonal growth of tumors. Mol Cell Biol 1991; 11: 108-16.