Synthesis and biological evaluation of 1′,2′-seconucleo-5′-phosphonates

Journal of Medicinal Chemistry

Volumn 39, Issue 5, 1996, Pages 1130-1135

  Racha, Saibaba ^a   Vargeese, Chandra ^a   Vemishetti, Purushotham ^a   El Subbagh, Hussein I ^a   Abushanab, Elie ^a   Panzica, Raymond P ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1',2' SECONUCLEOTIDE 5' PHOSPHONATE; ANTIVIRUS AGENT; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ADENOVIRUS; ANTIVIRAL ACTIVITY; ARTICLE; DRUG SCREENING; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; RNA VIRUS; VIRUS INFECTION;

ADENINE; ADENOVIRUSES, HUMAN; ANTIVIRAL AGENTS; CYSTINE; HIV; MOLECULAR STRUCTURE; NUCLEOTIDES; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; RNA VIRUSES; THYMINE; URACIL;

EID: 0029879333     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9506783     Document Type: Article

References (27)

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5. In the text, the naming and numbering of the 1′,2′-seconucleophosphonates follow nucleoside nomenclature; however, in the Experimental Section, the acyclic side chains of the title compounds are named and numbered in accordance with Chemical Abstracts Service nomenclature.
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23. 2N protons were not completely visible due to overlap with the HDO peak.
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27. Testing was conducted under the auspices of USAMRIID.