Theoretical design of prodrug-enhancer combination based on a skin diffusion model: Prediction of permeation of acyclovir prodrugs treated with 1-geranylazacycloheptan-2-one

Pharmaceutical Research

Volumn 13, Issue 3, 1996, Pages 427-432

  Bando, Hiroto ^a   Takagi, Toshihide ^a   Yamashita, Fumiyoshi ^a   Takakura, Yoshinobu ^a   Hashida, Mitsuru ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

1 Geranylazacycloheptan 2 one; Acyclovir; Percutaneous absorption; Prodrug enhancer combination

Indexed keywords

1 GERANYLAZACYCLOHEPTAN 2 ONE; ACICLOVIR; ACICLOVIR DERIVATIVE; PENETRATION ENHANCING AGENT; PRODRUG;

ANIMAL TISSUE; ARTICLE; DIFFUSION; DRUG SOLUBILITY; DRUG SYNTHESIS; FEMALE; LIPOPHILICITY; NONHUMAN; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; RAT; SKIN ABSORPTION; SKIN PENETRATION;

ACYCLOVIR; ANIMALS; AZEPINES; CELL MEMBRANE PERMEABILITY; CHEMISTRY, PHYSICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EPIDERMIS; MALE; PRODRUGS; RATS; RATS, WISTAR; SKIN ABSORPTION;

EID: 0029878649     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016000827719     Document Type: Article

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