Synthesis and pharmacology of combined histamine H1-/H2-receptor antagonists containing diphenhydramine and cyproheptadine derivatives

Archiv der Pharmazie

Volumn 329, Issue 2, 1996, Pages 87-94

  Wolf, Cornelia ^a   Schunack, Walter ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

cyproheptadine; diphenhydramine; histamine H1 receptor antagonism; histamine H2 receptor antagonism; tiotidine

Indexed keywords

ANTIHISTAMINIC AGENT; CYPROHEPTADINE; CYPROHEPTADINE DERIVATIVE; DIPHENHYDRAMINE; DIPHENHYDRAMINE DERIVATIVE; HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; HEART ATRIUM; ILEUM; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; STRUCTURE ACTIVITY RELATION;

EID: 0029878615     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.19963290206     Document Type: Article

References (28)

1. I. Robenson, M. W. Greaves, Br. J. Clin. Pharmacol. 1978, 5, 319-322.
2. E. Paul, R. H. Bödeker, Eur. J. Clin. Pharmacol. 1986, 31, 277-280.
3. S. S. Bleehen, S. E. Thomas, M. W. Greaves, J. Newton, C. T. C. Kennedy, F. Hindley, R. Marks, M. Hazell, N. R. Rowell, G. M. Fairiss, P. H. Cartwright, H. P. Glenny, K. Rowland, Br. J. Dermatol. 1987, 117, 81-88.
4. N. A. Soter, J. Allergy Clin. Immunol. 1990, 86, 1009-1014.
5. W. Dietz, B. Stinner, W. Lorenz, W. Dick, Th. Junginger, H. Menke, M. Rothmund, A. Doenicke, Inn. Med. 1990, 17, 129-135.
6. W. Lorenz, D. Duda, W. Dick, H. Sitter, A. Doenicke, A. Black, D. Weber, H. Menke, B. Stinner, Th Junginger, M. Rothemund, Ch. Ohmann, M. J. R. Healy, Lancet 1994, 343, 933-940.
7. C. R. Ganellin, R. C. Blakemore, T. H. Brown, D. G. Cooper, G. J. Durant, C. A. Harvey, R. J. Ife, D. A. A. Owen, M. E. Parsons, A. C. Rasmussen, G. S. Sach, N. Engl. Reg. Allergy Proc. 1986, 7, 126-133.
8. A. Buschauer, J. Med. Chem. 1989, 32, 1963-1970.
9. R. C. Young, G. J. Durant, J. C. Emmett, C. R. Ganellin, M. J. Graham, R. C. Mitchell, H. D. Prain, M. L. Roantree, J. Med. Chem. 1986, 29, 44-49.
10. D. J. Gilman, D.F. Jones, K. Oldham, J. M. Wardleworth, T. O. Yellin, Spec. Publ.-R. Soc. Chem. 1982, 42 (Chem. Regul. Biol. Mech.), 58-76.
11. F. R. Schulze, R. A. Alisch, A. Buschauer, W Schunack, Arch. Pharm. (Weinheim) 1994, 327, 455-462.
12. J. R. Geigy (A.-G.). Swiss 265753 and Swiss 265754. 1949 [Chem. Abstr. 1951, 45, P182g].
13. E. L. Engelhardt, H. C. Zell, W. S. Saari, M. E. Christy, C. D. Colton, J. Med. Chem. 1965, 8, 829-835.
14. R. A. Olofson, J. T. Martz, J. Org. Chem. 1984, 49, 2081-2082.
15. T. O. Yellin, D. J. Gilman, D. F. Jones, J. M. Wardleworth (Imperial Chemical Industries Ltd.; ICI Americas, Inc.). Ger. Offen. 2817078. 1978 [Chem. Abstr. 1979, 90, 87452d].
16. A. Buschauer, S. Postius, I. Szelenyi, W. Schunack, Arzneim.-Forsch. 1985, 35, 1025-1029.
17. J. R. Shanklin Jr., Ch. P. Johnson (A.H. Robins Co., Inc.). US 4500529. 1985 [Chem. Abstr. 1985, 103, P22300v].
18. H. A. Staab, W. Benz, Liebigs Ann. Chem. 1961, 648, 72-82.
19. H. Pertz, S. Elz, J. Pharm. Pharmacol. 1995, 47, 310-316.
20. J. W. Black, W. A. M. Duncan, G. J. Durant, C. R. Ganellin, M. E. Parsons, Nature (London) 1972, 236, 385-390.
21. J. M. van Rossum, Arch. Int. Pharmacodyn. Ther. 1963, 143, 299-330.
22. E. J. Ariens, J. M. van Rossum, Arch. Int. Pharmacodyn. 1957, 110, 275-299.
23. F. G. van den Brink, E. J. Lien in Handb. Exp. Pharmacol. (ed.: M. Rocha e Silva), Springer Verlag, Berlin, 1978, 18(2), 333-367.
24. O. Arunlakshana, H. O. Schild, Br. J. Pharmacol. 1959, 14, 48-58.
25. T. P. Kenakin, Can. J. Physiol. Pharmacol. 1982, 60, 249-265.
26. T. P. Kenakin in Pharmacologic Analysis of Drug-Receptor Interaction, Raven Press, New York 1993, 278-322.
27. R. Leurs, H. van der Goot, H. Timmerman in Adv. Drug Res. (ed.: B. Testa), Academic Press, London, 1991, 20, 218-304.
28. T. O. Yellin, S. H. Buck, D. J. Gilman, D. F. Jones, J. M. Wardleworth, Life Sci. 1979, 25, 2001-2009.