What changes drug metabolism in critically ill patients - III? Effect of pre-existing disease on the metabolism of midazolam

Anaesthesia

Volumn 51, Issue 5, 1996, Pages 431-434

  Miller, E ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Biotransformation (drug); Complications, cirrhosis, rejection; Liver, function; Liver; disease; Pharmacology, midazolam

Indexed keywords

CYTOCHROME P450; DRUG METABOLITE; HYPNOTIC SEDATIVE AGENT; MIDAZOLAM;

ADULT; ALCOHOL LIVER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CRITICAL ILLNESS; DRUG METABOLISM; ENZYME ACTIVITY; GRAFT REJECTION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; LIVER; LIVER MICROSOME; LIVER RESECTION; LIVER TRANSPLANTATION; ORGAN DONOR; PRIMARY BILIARY CIRRHOSIS; REOPERATION;

ADULT; BIOTRANSFORMATION; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; GRAFT REJECTION; HUMANS; HYPNOTICS AND SEDATIVES; LIVER; LIVER CIRRHOSIS, ALCOHOLIC; LIVER CIRRHOSIS, BILIARY; LIVER DISEASES; LIVER TRANSPLANTATION; MICROSOMES; MIDAZOLAM; MIDDLE AGED; MIXED FUNCTION OXYGENASES;

EID: 0029878604     PISSN: 00032409     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2044.1996.tb07785.x     Document Type: Article

References (3)

1. PARK GR. Pharmacokinetics and pharmacodynamics in the critically ill patient. Xenobiotica 1993; 23: 1195-230.
2. FABRE G, RAIIMANI R, PLACIDI M, COMBALBERT J, Covo J, CANO J, COULANGE C, DUCROS M, RAMPAL M. Characterisation of midazolam metabolism using hepatic microsomal fractions and hepatocytes in suspension obtained by perfusing whole human livers. Biochemical Phannacologv I988; 37: 4389-97.
3. TARBIT MU, BAYLISS MK, HERRIOTT D, HOOD SR, HUTSON JL, PARK GR, SERARIIT-SIN'GII CJ. Applications of molecular biology and in vitro technology to drug metabolism studies: an industrial perspective. Biochemical Society Transactions 1993; 21: 1018-23.