Hypersensitivity to rapamycin of BJAB B lymphoblastoid cells

Immunology

Volumn 87, Issue 3, 1996, Pages 390-395

  Kay, J E ^a   Smith, M C ^a   Frost, V ^a   Morgan, G Y ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; L 685818; RAPAMYCIN; TACROLIMUS; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE; CELL LINE; DRUG SENSITIVITY; HUMAN; LYMPHOBLASTOID CELL LINE; PRIORITY JOURNAL; T LYMPHOCYTE;

B-LYMPHOCYTES; CELL CYCLE; CELL DIVISION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; HUMANS; IMMUNOSUPPRESSIVE AGENTS; POLYENES; SIROLIMUS;

EID: 0029878486     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. MORRIS R.E. (1992) Rapamycins: antifungal, antitumour, anti-proliferative and immunosuppressive macrolides. Transplant Rev 6, 39.
2. SEHGAL S.N. (1993) Immunosuppressive profile of rapamycin. Ann NY Acad Sci 696, 1.
3. MCKEON F. (1991) When worlds collide: immunosuppressants meet protein phosphatases. Cell 66, 823.
4. SCHREIBER S.L. (1992) Immunophilin-sensitive protein phosphatase action in cell signaling pathways. Cell 70, 365.
5. DUMONT F.J., STARUCH M.J., KOPRAK S.L., MELINO M.R. & SIGAL N.H. (1990) Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin. J Immunol 144, 251.
6. DUMONT F.J., MELINO M.R., STARUCH M.J., KOPRAK S.L., FISCHER P.A. & SIGAL N.H. (1990) The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells. J Immunol 144, 1418.
7. BIERER B.E., MATTILA P.S., STANDAERT R.F. et al. (1990) Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc Natl Acad Sci USA 87, 9231.
8. KAY J.E., KROMWEL L., DOE S.E.A. & DENYER M. (1991) Inhibition of T and B lymphocyte proliferation by rapamycin. Immunology 72, 544.
9. BIERER B.E., SOMERS P.K., WANDLESS T.J., BURAKOKK S.J. & SCHREIBER S.L. (1990) Probing immunosuppressant action with a non-natural immunophilin ligand. Science 250, 556.
10. DUMONT F.J., STARUCH M.J., KOPRAK S.L. et al. (1992) The immunosuppressive and toxic effects of FK506 are mechanistically related - pharmacology of a novel antagonist of FK506 and rapamycin. J Exp Med 176, 751.
11. OCAIN T.D., LONGHI D., STEFFAN R.J., CACCESE R.G. & SEHGAL S.N. (1993) A nonimmunosuppressive triene-modified rapamycin analog is a potent inhibitor of peptidyl prolyl cis-trans isomerase. Biochem Biophys Res Commun 192, 1340.
12. LIU J. (1993) FK506 and cyclosporin, molecular probes for studying intracellular signal transduction. Immunol Today 14, 290.
13. BROWN E.J., ALBERS M.W., SHIN T.B. et al. (1994) A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369, 756.
14. SABATINI D.M., ERDJUMENT-BROMAGE H., LIU M., TEMPST P. & SNYDER S.H. (1994) RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78, 35.
15. KUNZ J., HENRIQUEZ R., SCHNEIDER U., DEUTER-REINHARD M., MOVVA N.R. & HALL M.N. (1993) Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 73, 585.
16. CAFFERKEY R., MCLAUGHLIN M.M., YOUNG P.R., JOHNSON R.K. & LIVI G.P. (1994) Yeast TOR proteins: amino acid sequence alignment and identification of structural motifs. Gene 141, 133.
17. KUO C.J., CHUNG J., FIORENTINO D.F., FLANAGAN W.M., BLENIS J. & CRABTREE G.R. (1992) Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 358, 70.
18. CHUNG J., KUO C.J., CRABTREE G.R. & BLENIS J. (1992) Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 69, 1227.
19. s6k through dephosphorylation of a novel set of sites. J Biol Chem 268, 16091.
20. KAY J.E., SAMPARE-KWATENG E., GERAGHTY F. & MORGAN G.Y. (1991) Uptake of FK506 by lymphocytes and erythrocytes. Transplant Proc 23, 2760.
21. TERADA N., PATEL H.R., TAKASE K., KOHNO K., NAIRN A.C. & GELFAND E.W. (1994) Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc Natl Acad Sci USA 91, 11477.
22. TERADA N., FRANKLIN R.A., LUCAS J.J., BLENIS J. & GELFAND E.W. (1993) Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase. J Biol Chem 268, 12062.
23. KAY J.E., WELLHAUSEN A., FROST V., MORGAN G.Y., SMITH M.C. & MORLEY S.J. (1996) Rapamycin-resistant human lymphoid cell lines. Biochem Soc Trans 24, 89S.
24. DUMONT F.J., ALTMEYER A., KASTNER C. et al. (1994) Relationship between multiple biologic effects of rapamycin and the inhibition of pp70S6 protein kinase activity. J Immunol 152, 992.
25. AKSELBAND Y., HARDING M.W. & NELSON P.A. (1991) Rapamycin inhibits spontaneous and FGFβ-stimulated proliferation in endothelial cells and fibroblasts. Transplant Proc 23, 2833.
26. PRICE D.J., GROVE J.R., CALVO V., AVRUCH J. & BIERER B.E. (1992) Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science 257, 973.
27. rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or FcεRI: rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells. Eur J Immunol 23, 3286.
28. ALBERS M.W., WILLIAMS R.T., BROWN E.J., TANAKA A., HALL F.L. & SCHREIBER S.L. (1993) FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line. J Biol Chem 268, 22825.
29. CALVO V., WOOD M., GJERTSON C., VIK T. & BIERER B.E. (1994) Activation of 70-kDa S6 kinase, induced by the cytokines interleukin-3 and erythropoietin, is not an absolute requirement for cell proliferation. Eur J Immunol 24, 2664.
30. CHEN Y., CHEN H., RHOAD A.E. et al. (1994) A putative sirolimus (rapamycin) effector protein. Biochem Biophys Res Commun 203, 1.
31. NAPOLI K.L. & KAHAN B.D. (1994) Sample clean-up and high-performance liquid-chromatographic techniques for measurement of whole blood rapamycin concentrations. J Chromatog 654, 111.
32. WANG C.P., SCATINA J. & SISENWINE S.F. (1995) Determination of rapamycin (Sirolimus) in rat serum, plasma and blood and in monkey serum. J Liquid Chromatog 18, 1801.