Enzymatic cytochemistry, DNA ploidy and AgNOR quantitation in hepatocellular nodules of uncertain malignant potential in liver cirrhosis

Digestive Diseases and Sciences

Volumn 41, Issue 4, 1996, Pages 800-808

  Bolondi, Luigi ^a   Gramantieri, Laura ^b   Chieco, Pasquale ^b   Melchiorri, Cinzia ^b   Trerè, Davide ^b   Stecca, Barbara ^b   Derenzini, Massimo ^b   Barbara, Luigi ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b NONE

Author keywords

argyrophilic nucleolar organizer regions; dipeptidyl peptidase IV; DNA ploidy; hepatocellular carcinoma; liver cirrhosis; macroregenerative nodules

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; AGED; ARTICLE; CHROMOSOME NOR; CLINICAL ARTICLE; CYTOCHEMISTRY; ECHOGRAPHY; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; LIVER BIOPSY; LIVER CIRRHOSIS; LIVER NODULE; MALE; PLOIDY; PRIORITY JOURNAL; STAINING;

ANTIGENS, CD26; BIOPSY; CARCINOMA, HEPATOCELLULAR; DIAGNOSIS, DIFFERENTIAL; DNA; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMAGE CYTOMETRY; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NUCLEOLUS ORGANIZER REGION; PLOIDIES; SILVER NITRATE; TIME FACTORS;

EID: 0029877744     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02213139     Document Type: Article

References (34)

1. Wada K, Kondo F, Kondo Y: Large regenerative nodules and dysplastic nodules in cirrhotic livers: A histopathologic study. Hepatology 8:1684-1688, 1988
2. Kondo K, Hirooka N, Wada K, Kondo Y: Morphological clues for the diagnosis of small hepatocellular carcinomas. Virchows Arch A 411:15-21, 1987
3. Kondo F, Wada K, Nagato Y, Nakajima T, Kondo Y, Hirooka N, Ehara M, et al: Biopsy diagnosis of well differentiated hepatocellular carcinoma based on new morphologic criteria. Hepatology 9:751-755, 1989
4. Furuya K, Nakamura M, Yamamoto Y, Togei K, Otsuka H: Macroregenerative nodule of the liver. A clinicopathologic study of 345 autopsy cases of chronic liver disease. Cancer 61:99-105, 1988
5. Ferrell LD, Crawford JM, Dhillon AP, Scheuer PJ, Nakanuma Y: Proposal for standardized criteria for the diagnosis of benign, borderline, and malignant hepatocellular lesions arising in chronic advanced liver disease. Am J Surg Pathol 17(11):1113-1123, 1993
6. International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 22:983-993, 1995
7. Arakawa M, Kage M, Sugihara S, Nakashima T, Suenaga M, Okuda K: Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver. Observations in five cases. Gastroenterology 91:198-208, 1986
8. Takayama T, Makuuchi M, Hirohashi S, Sakamoto M, Okazaki N, Takayasu K, Kosuge T, et al: Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet 336:1150-1153, 1990
9. Kondo F, Ebara M, Sugiura N, Wada K, Kita K, Hirooka N, Nagato Y, et al: Histological feature and clinical course of large regenerative nodules: Evaluation of their precancerous potentiality. Hepatology 12:592-598, 1990
10. Rapaccini GL, Pompili M, Caturelli E, Anti M, Aliotta A, Cedrone A, Amadei E, et al: Focal ultrasound lesions in liver cirrhosis diagnosed as regenerating nodules by fine-needle biopsy. Follow-up of 12 cases. Dig Dis Sci 35:422-427, 1990
11. Matsumoto Y, Bishop GA, McCaughan GW: Altered zonal expression of the CD 26 antigen (dipeptidyl peptidase IV) in human cirrhotic liver. Hepatology 15:1048-1053, 1992
12. Saeter G, Lee C, Schwarze P, Ous S, Chen D, Sung J, Seglen P: Changes in ploidy distributions in human liver carcinogenesis. J Natl Cancer Inst 80:1480-1485, 1988
13. Jack EM, Bentley P, Bieri F, Muakkassah-Kelly S, Staubly W, Suter J, Waechter F, Cruz-Orive L: Increase in hepatocyte and nuclear volume and decrease in the population of binucleated cells in preneoplastic foci of rat liver: a stereological study using the nucleator method. Hepatology 11:286-297, 1990
14. Orsatti G, Theise ND, Thung SN, Paronetto F: DNA image cytometric analysis of macroregenerative nodules (adenomatous hyperplasia) of the liver: evidence in support of their preneoplastic nature. Hepatology 17:621-627, 1993
15. Derenzini M, Trerè D, Oliveri F, David E, Colombatto P, Bonino F, Brunetto MR: Is high AgNOR quantity in hepatocytes associated with increased risk of hepatocellular carcinoma in cirrhotic liver disease? J Clin Pathol 46:727-729, 1993
16. Melchiorri C, Chieco P, Vedda AI, Coni P, Ledda-Columbano GM, Columbano A: Ploidy and nuclearity of rat hepatocytes after compensatory regeneration or mitogen-induced liver growth. Carcinogenesis 14:1825-1830, 1993
17. Prenna G, Leiva S, Mazzini G: Quantitation of DNA by cytofluorimetry of the conventional Feulgen reaction. Histochemical J 6:467-489, 1974
18. Ploton D, Menager M, Jeannesson P, Himber G, Pigeon F, Adnet JJ: Improvement in the staining and in the visualization of the argyrophilic proteins of the nucleolar organizer region at the optical level. Histochem J 18:5-14, 1986
19. McNeil BJ, Keeler E, Adelstein SJ: Primer on certain elements of medical decision making. N Engl J Med 293:211-215, 1975
20. Ferrell L, Wright T, Lake J, Roberts J, Ascher N. Incidence and diagnostic features of macroregenerative nodules vs small hepatocellular carcinoma in cirrhotic livers. Hepatology 16:1372-1381, 1992
21. Theise ND, Schwartz M, Miller C, Thung SN: Macroregenerative nodules and hepalocellular carcinoma in forty-four sequential adult liver expiants with cirrhosis. Hepatology 16:949-955, 1992
22. Terada T, Terasaki S, Nakanuma Y. A clinicopathologic study of adenomatous hyperplasia of the liver in 209 consecutive cirrhotic livers examined by autopsy. Cancer 72:1551-1556, 1993
23. Eguchi A, Nakashima O, Okudaira S, Sugihara S, Kojiro M: Adenomatous hyperplasia in the vicinity of small hepatocellular carcinoma. Hepatology 15:843-848, 1992
24. Theise N, Lapook JD, Thung SN: A macroregenerative nodule containing multiple foci of hepatocellular carcinoma in a noncirrhotic liver. Hepatology 17:993-996, 1993
25. Schlagenhauff B, Klessen C, Teichmann-Dorr S, Breuninger H, Rassner G: Demonstration of proteases in basal cell carcinomas. Cancer 70:1133-1140, 1992
26. Stecca BA, Chieco P, Fusconi F, Melchiorri C, Gaiani S, Bolondi L, Barbara L: Alteration of dipeptidyl-peptidase IV (DPP IV) distribution in human hepatocellular carcinoma (HCC). Gastroenterology 104:A999, 1993
27. Lin H, Shyu W, Chen G, Lin Y, Chen T, Liaw Y: DNA measurements in chronic hepatitis, cirrhosis and hepatocellular carcinoma. Liver 10:313-318, 1990
28. Kuo S, Sheu J, Chen D, Sung J, Lin C, Hsu H: Cytophotometric measurements of nuclear DNA content in hepatocellular carcinomas. Hepatology 7:330-332, 1987
29. Melchiorri C, Bolondi L, Chieco P, Pagnoni M, Grumantieri L, Barbara L: Diagnostic and prognostic value of DNA ploidy and cell nuclearity in ultrasound-guided liver biopsies. Cancer 74:1713-1719, 1994
30. Trerè D, Pession A, Derenzini M: The silver-stained proteins of interphase nucleolar organizer regions as a parameter of cell duplication rate. Exp Cell Res 184:131-137, 1989
31. Derenzini M, Trerè D: Importance of interphase nucleolar organizer regions in tumor pathology. Virchows Arch Cell Pathol B 61:1-8, 1991
32. Pich A, Chiusa L, Pisani P, Krengli M, Pia F, Navone R: Argyrophilic nucleolar organizer region counts and proliferating cell nuclear antigen scores are two indicators of survival in pharyngeal carcinoma. J Cancer Res Clin Oncol 119:106-110, 1992
33. Tarao K, Shimizu A, Harada M, Kuni Y, Ito Y, Tamai S, Iimori K et la: Difference in the in vitro uptake of bromodeoxyuridine between liver cirrhosis with and without hepatocellular carcinoma. Cancer 64:104-109, 1989
34. Tarao K, Shimizu A, Ohkawa S, Harada M, Ito Y, Tamai S, Kuni Y, et al: Development of hepatocellular carcinoma associated with increase in DNA synthesis in the surrounding cirrhosis. Gastroenterology 103:595-600, 1992