Thermodynamics and kinetics of t-butylbicyclophosphorothionate binding differentiate convulsant and depressant barbiturate stereoisomers acting via GABAA ionophores

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 353, Issue 3, 1996, Pages 306-313

  Maksay, Gábor ^a   Molnár, Péter ^b   Simonyi, Miklós ^a  

^a CTRL RES INSTITUTE FOR CHEMISTRY   (Hungary)

^b Chinoin Pharmaceutical and Chemical Works Ltd   (Hungary)

Author keywords

Arrhenius analysis; Barbiturate stereoisomers; Dissociation of 35S TBPS binding; Electrophysiology of GABAA ionophores; GABAA receptor ionophore complex; Thermodynamics of barbiturate binding

Indexed keywords

1 METHYL 5 PHENYL 5 PROPYLBARBITURIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; BARBITURIC ACID DERIVATIVE; CENTRAL DEPRESSANT AGENT; CONVULSANT AGENT; SULFUR 35; TERT BUTYLBICYCLOPHOSPHOROTHIOATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING KINETICS; BRAIN CORTEX; BRAIN MEMBRANE; BRAIN NERVE CELL; CENTRAL NERVOUS SYSTEM DEPRESSION; CHLORIDE CURRENT; CONTROLLED STUDY; CONVULSION; DISSOCIATION CONSTANT; ENANTIOMER; ENTHALPY; ENTROPY; FOREBRAIN; MALE; NERVE CELL CULTURE; NONHUMAN; PATCH CLAMP; RAT; TEMPERATURE; THERMODYNAMICS;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING, COMPETITIVE; CELLS, CULTURED; CEREBRAL CORTEX; CONVULSANTS; ELECTROPHYSIOLOGY; IONOPHORES; KINETICS; MALE; PATCH-CLAMP TECHNIQUES; PHENOBARBITAL; PROSENCEPHALON; RATS; RATS, WISTAR; RECEPTORS, GABA-A; STEREOISOMERISM; SYNAPTOSOMES; THERMODYNAMICS;

EID: 0029876741     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00168633     Document Type: Article

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