Impaired endothelium-dependent vasodilation of coronary resistance vessels in hypercholesterolemic patients

Internal Medicine

Volumn 35, Issue 2, 1996, Pages 89-93

  Shiode, Nobuo ^a   Kato, Masaya ^a   Hiraoka, Akito ^a   Yamagata, Togo ^a   Matsuura, Hideo ^a   Kajiyama, Goro ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

acetylcholine; endothelium derived relaxing factor (EDRF); hypercholesterolemia

Indexed keywords

ACETYLCHOLINE; ADENOSINE;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY VESSEL MALFORMATION; ENDOTHELIUM; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; INTRACARDIAC DRUG ADMINISTRATION; MALE; STENOSIS; VASODILATATION;

EID: 0029876610     PISSN: 09182918     EISSN: None     Source Type: Journal    
DOI: 10.2169/internalmedicine.35.89     Document Type: Article

References (21)

1. Vane RE, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med 323: 27, 1990.
2. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373, 1980.
3. Ludmer PL, Selwyn AP, Shook TL, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 315: 1046, 1986.
4. Ross R. The pathogenesis of atherosclerosis - an update N Engl J Med 314: 188, 1986.
5. Yasue H, Matsuyama K, Okumura K, Morikami Y, Ogawa H. Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment. J Am Coll Cardiol 81:482, 1990.
6. Vita J, Treasure CB, Nabel EG, et al. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. J Am Coll Cardiol 81: 491, 1990.
7. Creager MA, Cooke JP, Mendelsohn ME, et al. Hypercholesterolemia attenuates endothelium-mediated vasodilation in man. J Clin Invest 86: 228, 1990.
8. Zeiher AM, Drexler H, Woltschlyger H, Just H. Modulation of coronary vascular tone in humans: Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 83: 391, 1991.
9. Egashira K, Inou T, Hirooka Y, et al. Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions. J Clin Invest 91: 29, 1993.
10. Zeiher AM, Drexler H, Saurbier B, Just H. Endothelium-mediated coronary blood flow modulation in humans. J Clin Invest 92: 652, 1993.
11. Lucher TF, Richard V, Tschudi M, Yang Z, Boulanger C. Endothelial control of vascular tone in large and small coronary arteries. J Am Coll Cardiol 15: 512, 1990.
12. Zeiher AM, Drexler H, Saurbier B, Just H. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension: endothelium-mediated coronary blood flow modulation in humans. J Clin Invest 92: 652, 1993.
13. Sellke FW, Armstrong ML, Harrison DG. Endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates. Circulation 81: 1586, 1990.
14. Gardiner GA, Meyerovitz MF, Boxt LM, et al. Selective coronary angiography using a power injector. Am J Radiol 146: 831, 1986.
15. Mancini GBJ, Simon SB, McGillen J, LeFree M, Friedman H, Vogel RA. Automated quantitative coronary arteriography: morphologic and physiologic validation in vivo of a rapid digital angiographic method. Circulation 75: 452, 1987.
16. Reiber JHC, Serruys PW, Kooijman CJ, et al. Assessment of short-, medium-, and long-term variations in arterial dimensions from computer-assisted quantification of coronary cineangiograms. Circulation 71: 280, 1985.
17. Schroeder JS, Bolen JL, Quint RA, et al. Provocation of coronary spasm with ergonovine maleate. Am J Cardiol 40: 87, 1977.
18. Werns SW, Walton JA, Hsia HH, Nabel EG, Sanz ML, Pitt B. Evidence of endothelial dysfunction in angiographically normal coronary arteries of patients with coronary artery disease. Circulation 79: 287, 1989.
19. Zeiher AM, Krause T, Schachinger V, Minners J, Moser E. Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia. Circulation 91: 2345, 1995.
20. Egashira K, Hirooka Y, Kai H, et al. Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia. Circulation 89: 2519, 1994.
21. Egashira K, Inou T, Hirooka Y, et al. Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation 88: 77, 1993.