Functional and binding characteristics of long-acting β2-agonists in lung and heart

American Journal of Respiratory and Critical Care Medicine

Volumn 153, Issue 5, 1996, Pages 1489-1495

  Roux, Francoise J ^a,b   Grandordy, Beatrice ^c   Douglas, James S ^c  

^a Philippe Foundation   (France)

^b JOHN B PIERCE LABORATORY   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; FENOTEROL; FORMOTEROL; HEART RECEPTOR; ISOPRENALINE; LONG ACTING DRUG; SALBUTAMOL; SALMETEROL; SOTERENOL;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; ASTHMA; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; FEMALE; LUNG RECEPTOR; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029876543     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.153.5.8630591     Document Type: Article

References (31)

1. Svedmyr, N., and C. G. Löfdahl. 1987. Physiology and pharmacodynamics of beta-adrenergic agonists. In J. W. Jenne and D. Murphy, editors. Drug Therapy for Asthma. Research and Clinical Practice. Marcel Dekker, New York. 177-211.
2. Spitzer, W. O., S. Suissa, P. Ernst, R. I. Horwitz, D. Cockcroft, J. F. Boivin, M. McNutt, and A. S. Buist. 1992. The use of β-agonists and the risk of death from asthma. N. Engl. J. Med. 326:501-506.
3. 2-adrenoceptor agonists: a new persepctive in the treatment of asthma. Eur. Respir. J. 4:218-226.
4. Wong, C. S., I. D. Pavord, J. Williams, J. R. Britton, and A. E. Tattersfield. 1990. Bronchodilator, cardiovascular, and hypokalaemic effects of formoterol, albuterol and terbutaline in asthma. Lancet 336:1396-1399.
5. 2-receptor stimulation by circulating epinephrine. Am. J. Cardiol. 56:3D-9D.
6. Brittain, R. T., C. M. Dean, and D. Jack. 1981. Sympathomimetic bronchodilator drugs. In J. G. Widdicombe, editor. Respiratory Pharmacology. Pergamon Press, New York. 613-701.
7. Repsher, L. H., J. A. Anderson, and R. W. Bush. 1984. Assessment of tachyphylaxis following prolonged therapy of asthma with inhaled albuterol aerosol. Chest 85:34-38.
8. Nijkamp, F. P., and A. J. Henricks. 1990. β-adrenoceptors in lung inflammation. Am. Rev. Respir. Dis. 141:S145-S150.
9. Faulds, D., L. M. Holilngshead, and K. L. Goa. 1991. Formoterol: a review of pharmacological properties and therapeutic potential in reversible obstructive airways disease. Drug 42:115-137.
10. 2-adrenoceptor agonist: characterization of pharmacological activity in vitro and in vivo. Br. J. Pharmacol. 104:665-671.
11. Orehek, J., J. S. Douglas, and A. Bouhuys. 1975. Contractile responses of the guinea pig trachea in vitro: modification by prostaglandin synthesis-inhibiting drugs. Br. J. Pharmacol. 194:554-564.
12. Lowry, O. H., M. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:265-275.
13. McPherson, G. A. 1985. Analysis of radioligand binding experiments: a collection of computer programs for the IBM PC. J. Pharmacol. Methods 14:213-228.
14. Liang, B. T., and P. B. Molinoff. 1986. Beta-adrenergic receptor subtypes in the atria: evidence for close coupling of beta1 and beta2-adrenergic receptors to adenylate cyclase. J. Pharmacol. Exp. Ther. 238:886-892.
15. 2-adrenoceptors in mammalian lung: evidence from direct binding studies. Mol. Pharmacol. 14:996-1005.
16. Weinryb, I., M. Michel, and S. M. Hess. 1973. Adenylate cyclase from guinea pig lung: further characterization and inhibitory effects of substrate analogs and cyclic nucleotides. Arch. Biochem. Biophys. 152: 240-249.
17. Kent, R. S., A. De Lean, and R. J. Lefkowitz. 1980. A quantitative analysis of β-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data. Mol. Pharmacol. 17:14-23.
18. Cerione, R. A., D. R. Sibley, J. Codina, J. L. Benovic, J. Winslow, E. J. Neer, L. Birnbaumer, M. G. Caron, and R. J. Lefkowitz. 1984. Reconstitution of a hormone-sensitive adenylate cyclase system: the pure β-adrenergic receptor and guanine nucleotide regulatory proteins confer hormone responsiveness on the resolved catalytic unit. J. Biol. Chem. 259:9979-9982.
19. Van Amsterdam, R. G., H. Meurs, E. J. Ten-Berge, C. M. Veninga, F. Brouwer, and J. Zaagsma. 1990. Role of phosphoinositide metabolism in human bronchial smooth muscle contraction and in functional antagonism by beta-adrenoceptor agonists. Am. Rev. Respir. Dis. 142:1124-1128.
20. Grandordy, B. M., F. M. C. Cuss, A. S. Sampson, J. B. D. Palmer, and P. J. Barnes. 1986. Phosphatidylinositol response to cholinergic agonists in airway smooth muscle: relationship to contraction and muscarinic receptor occupancy. J. Pharmacol. Exp. Ther. 238:273-278.
21. Buckner, C. K., and R. K. Saini. 1975. On the use of functional antagonism to estimate dissociation constants for beta-adrenergic receptor agonists in isolated guinea-pig trachea. J. Pharmacol. Exp. Ther. 194: 565-574.
22. Roux, F., E. Mavoungou, H. Lacroix, E. Naline, C. Tordet, C. Advenier, and B. M. Grandordy. 1995. Role of diacylglycerol in smooth muscle stimulated by carbachol. Am. J. Respir. Crit. Care Med. 151: 1745-1751.
23. Grandordy, B. M., J. Mak, and P. J. Barnes. 1994. Modulation of airway smooth muscle function by a muscarinic agonist. Life Sci. 54: 185-191.
24. Anderson, G. P., A. Linden, and K. Rabe. 1994. Why are long-acting beta-adrenoceptor agonists long-acting? Eur. Respir. J. 7:569-578.
25. Jeppsson, A. B., C. G. Löfdahl, B. Waldeck, and E. Widmark. 1989. On the predictive value of experiments in vitro in the evaluation of the effect duration of bronchodilator drugs for local administration. Pulm. Pharmacol. 2:81-85.
26. 1 adrenoceptor selectivity of antagonists from pA2 values on guinea-pig trachea and atria. Naunyn Schmiedeberg's Arch. Pharmacol. 308:183-190.
27. Naline, E., G. P. Anderson, N. Mairon, B. M. Grandordy, and C. Advenier. 1994. Characterization of functional effects of formoterol and salmeterol in human lung. Eur. Respir. J. 7:914-920.
28. Johnson, M. 1991. The preclinical pharmacology of salmeterol bronchodilator effects. Eur. Respir. J. 1:253-256.
29. 2-sympathomimetic convert to less potent partial agonists as relaxants of trachea maximally contracted by carbachol. Comparison of relaxation with receptor binding and adenylate cyclase stimulation. J. Pharmacol. Exp. Ther. 261:258-270.
30. Maesen, F. P. V., R. Costongs, J. J. Smeets, P. J. Brombacher, and P. G. Zweers. 1991. The effect of maximal doses of formoterol and albuterol from a metered dose inhaler on pulse rates, ECG, and serum potassium concentrations. Chest 99:1367-1373.
31. 2-agonist. B.M.J. 301:1365-1368.