Shock revelations about HLA-DR4 - A shortcut to rheumatoid arthritis?

Nature Medicine

Volumn 2, Issue 3, 1996, Pages 279-280

  Ollier, Bill ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN; HLA DR4 ANTIGEN;

HUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SHORT SURVEY;

ALLELES; ARTHRITIS, RHEUMATOID; HEAT-SHOCK PROTEINS; HLA-DR4 ANTIGEN; HUMANS; MODELS, BIOLOGICAL; PROTEIN BINDING;

EID: 0029876471     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0396-279     Document Type: Short Survey

References (8)

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2. Auger, I., Escola, J.M., Gorvel, J.P. & Roudier, J. HLA-DR4 and HLA-DR10 motifs that carry susceptibility to rheumatoid arthritis bind 70-kD heat shock proteins. Nature Med. 2, 306-310 (1996).
3. Ollier, W. & Thomson, W. Population genetics of rheumatoid arthritis. in Rheumatic Disease Clinics of North America (ed. Dudlick, B.) 741-759 (Saunders, Pennsylvania, 1992).
4. Gregersen, P.K., Silver, J. & Winchester, R.J. The shared epitope hypothesis: An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 30, 1205-1213 (1987).
5. Roudier, J., Petersen, J., Rhodes, G., Luka, J. & Carson, D.A. Susceptibility to rheumatoid arthritis maps to a T cell epitope shared by the HLA-Dw4 DRβ1 chain and the Epstein Barr virus glycoprotein gp110. Proc. Natl. Acad. Sci. USA 86, 5104-5108 (1989).
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7. Salvat, S. et al. Tolerance to a self peptide from the third hypervariable region of HLA-DRB1*0401 in rheumatoid arthritis patients and normal subjects. J. Immunol. 153, 5321-5329 (1994)
8. Sargent, C.A., Dunham, I., Trowsdale, J. & Campbell, R.D. Human major histocompatibility complex contains genes for the major heat shock protein HSP70. Proc. Natl. Acad. Sci. USA 86, 1968-1972 (1989).