Inhibitors of leukotriene B4. Synthesis and sar of new ß-enaminoester open-chain analogues of Zeneca ZD2138

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 5, 1996, Pages 515-520

  Bird, T Geoffrey C ^a   Olivier, Annie ^a  

^a Centre de Recherches   (France)

Author keywords

[No Author keywords available]

Indexed keywords

SIGANUS;

6 [[3 FLUORO 5 (3,4,5,6 TETRAHYDRO 4 METHOXY 2H PYRAN 4 YL)]PHENOXYMETHYL] 1 METHYL 2 QUINOLONE; CARBOSTYRIL DERIVATIVE; LEUKOTRIENE B4; LIPOXYGENASE INHIBITOR; TETRAHYDROPYRAN DERIVATIVE;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INFRARED SPECTROPHOTOMETRY; NONHUMAN; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE; ORAL DRUG ADMINISTRATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; REACTION ANALYSIS;

EID: 0029876382     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00058-3     Document Type: Article

References (27)

1. For recent general reviews see: (a) Walker, E. R. H. Eur. J. Med. Chem. 1995, 30, (Suppl.), 399s. (b) Garland, L. G.; Hodgson, S. T. Adv. Prostaglandin, Thromboxane, Leukotriene Res. 1994, 22, 33.
2. For recent general reviews see: (a) Walker, E. R. H. Eur. J. Med. Chem. 1995, 30, (Suppl.), 399s. (b) Garland, L. G.; Hodgson, S. T. Adv. Prostaglandin, Thromboxane, Leukotriene Res. 1994, 22, 33.
3. Albert, D. H.; Machinist, J.; Young, P. R.; Dyer, R.; Bouska, J.; Brooks, D. W.; Carter, G. W. FASEB J. 1989, 3, A735, Abstr. 2954.
4. Bruneau, P.; Delvare, C.; Edwards, M. P.; McMillan, R. M. J. Med. Chem. 1991, 34, 1028.
5. Crawley, G. C.; Dowell, R. I.; Edwards, P. N.; Foster, S. J.; McMillan, R. M.; Walker, E. R. H.; Waterson, D.; Bird, T. G. C.; Bruneau, P.; Girodeau, J.-M. J. Med. Chem. 1992, 35, 2600.
6. Crawley, G. C.; Briggs, M. T.; Dowell, R. I.; Edwards, P. N.; Hamilton, P. M.; Kingston, J. F.; Oldham, K.; Waterson, D.; Whalley, D. P. J. Med. Chem. 1993, 36, 295.
7. Lambert-van der Brempt, C.; Bruneau, P.; Lamorlette, M. A.; Foster, S. J. J. Med. Chem. 1994, 37, 113.
8. Sanchez, A. G.; Aldave, M. T. J. Chem. Soc. (C) 1968, 2570.
9. Hannick, S. M.; Kiski, Y. J. Org. Chem. 1983, 48, 3833.
10. Gassman, P. G.; Talley, J. J. Tetrahedron Lett. 1978, 40, 3773.
11. Ito, Y.; Imai, H.; Segoe, K.; Saegusa, T. Chem. Lett. 1984, 937.
12. -1.
13. 3) of the corresponding bromo derivative previously described by Crawley, G. C.; Edwards, P. N.; E.P. 385662, 1990. C.A. 1990, 114, 228757 k.
14. Vogel, H. A. J. Am. Chem. Soc. 1951, 73, 4195.
15. Taber, D. F.; Amedio, J. C.; Patel. Y. K. J. Org. Chem. 1985, 50, 3618.
16. Rehberg, C. E. Org. Syn. 1955, coll. vol. 3, 146.
17. Larock, R. C. Comprehensive Org. Transformations 1989, 985.
18. 4.
19. (b) Meyers, A. I.; Temple, D. L.; Nolen R. L.; Mihelich E. D. J. Org. Chem. 1974, 39, 2778. (Matrix Presented)
20. 18c
21. (b) Henecka, H.; Chem. Ber. 1949, 82, 104.
22. (c) Becker, H. G. O. J. Prakt. Chem. 1961, 12, 294.
23. (d) Southwick, P. L.; Hofmann, G. H.; J. Org. Chem. 1963, 28, 1332.
24. (e) Kloek, J. A.; Leschinsky, K. L. J. Org. Chem. 1978, 43, 1460.
25. Described by Abbott Labs., patent US5268379-A, 7 December 1993.
26. Foster, S. J.; Bruneau, P.; Walker, E. R. H.; McMillan, R. M. Br. J. Pharmacol. 1990, 99, 113.
27. 4.