Carnitine-related alterations in patients with intermittent claudication: Indication for a focused carnitine therapy

Circulation

Volumn 93, Issue 9, 1996, Pages 1685-1689

  Brevetti, Gregorio ^a,b   Di Lisa, Fabio ^a   Perna, Sergio ^a   Menabó, Roberta ^a   Barbato, Roberta ^a   Martone, Vincenzo Domenico ^a   Siliprandi, Noris ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b NONE   (Italy)

Author keywords

carnitine; claudication; peripheral vascular disease

Indexed keywords

ACETYLCARNITINE; CARNITINE; PLACEBO;

ARTERY DISEASE; ARTICLE; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; EXERCISE; HUMAN; INTERMITTENT CLAUDICATION; INTRAVENOUS DRUG ADMINISTRATION; PHYSICAL STRESS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; WALKING;

EID: 0029876323     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.93.9.1685     Document Type: Article

References (25)

1. Brevetti G, Chiariello M, Ferulano G, Policicchio A, Nevola E, Attisano T, Ambrosio G, Siliprandi N, Angelin, C. Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double-blind, cross-over study. Circulation. 1988; 77:767-773.
2. Bieber LL. Carnitine. Annu Rev Biochem. 1988;57:261-283.
3. Kerney AL, Randle PJ, Cooper RH, Whithouse S, Pask HT, Denton RM. Regulation of pyruvate dehydrogenase in rat heart. Biochem J. 1976;11:327-348.
4. Hulsmann WC, Siliprandi D, Ciman M, Siliprandi N. Effect of carnitine on the oxidation of a-oxoglutarate to succinate in the presence of acetoacetate or pyruvate. Biochem Biophys Acta. 1966; 93:166-168.
5. Uziel G, Garavaglia B, Di Donato S. Carnitine stimulation of pyruvate dehydrogenase complex (PDHC) in isolated human skeletal muscle mitochondria. Muscle Nerve. 1988;11:720-724.
6. Lysiak W, Lilly K, Di Lisa F, Toth P, Bieber LL. Quantitation of the effect of L-carnitine on the levels of acid-soluble short-chain acyl-CoA and CoASH in rat heart and liver mitochondria. J Biol Chem. 1988;263:1151-1157.
7. Harris RC, Foster CVL, Hultman E. Acetylcarnitine formation during intense muscular contraction in humans. J Appl Physiol. 1987;63:440-442.
8. Lennon DLF, Stratman FW, Shirago E, Nagle FJ, Maddem M, Harrson P, Carter AL. Effects of acute moderate intensive exercise on carnitine metabolism in men and women. J Appl Physiol. 1983; 55:489-494.
9. Hiatt WR, Regensteiner JG, Wolfel EE, Ruff L, Brass EP. Carnitine and acylcarnitine metabolism during exercise in humans: dependence on skeletal muscle metabolic state. J Clin Invest. 1989; 84:1167-1173.
10. Spriet LL, MacLean DA, Dyck DJ, Hultman E, Cederblad G, Graham TE. Caffeine ingestion and muscle metabolism during prolonged exercise in humans. Am J Physiol. 1992;262:E891-E898.
11. Hiatt WR, Nawaz D, Brass EP. Carnitine metabolism during exercise in patients with peripheral vascular disease. J Appl Physiol. 1987;62:2383-2387.
12. Hiatt WR, Wolfel EE, Regensteiner JG, Brass EP. Skeletal muscle carnitine metabolism in patients with unilateral peripheral arterial disease. J Appl Physiol. 1992;73:346-353.
13. Gillings D, Koch G, Reich T, Stager WJ. Another look at the pentoxifylline efficacy data for intermittent claudication. J Clin Pharmacol. 1987;27:601-609.
14. Radack K, Wydersky RJ. Conservative management of intermittent claudication. Ann Intern Med. 1990;113:135-146.
15. Noel H, Parvin R, Pande SV. Gamma-butyrohetaine determined by an enzymatic radioisotopic procedure. Biochem J. 1984;220: 701-706.
16. Fishlock RC, Bieber LL, Snoswell AM. Sources of error in determinations of carnitine and acylcarnitine in plasma. Clin Chem. 1984;30:316-318.
17. Pande SV. Radioisotopic assay of acetylcarnitine and acetyl CoA. Methods Enzymol. 1986;123:259-263.
18. Kerner J, Bieber LL. Short-chain acylcarnitines: identification and quantification. Methods Enzymol. 1986;123:264-276.
19. Brevetti G, Angelini C, Rosa M, Carrozzo R, Perna S, Corsi M, Matarazzo A, Marcialis M. Muscle carnitine deficiency in patients with severe peripheral vascular disease. Circulation. 1991;84:1490-1495.
20. Brass EP, Hoppel CL. Carnitine metabolism in the fasting rat. J Biol Chem. 1978;253:2688-2693.
21. Brass EP, Hoppel CL. Relationship between acid-soluble carnitine and coenzyme A pools in vivo. Biochem J. 1980;190:495-504.
22. Hoppel CL, Genuth SM. Carnitine metabolism in normal-weight and obese human subjects during fasting. Am J Physiol. 1980;238: E409-E415.
23. Friolet R, Hoppeler H, Krahenbuhl S. Relationship between the coenzyme A and the carnitine pools in human skeletal muscle at rest and after exhaustive exercise under normoxic and acutely hypoxic conditions. J Clin Invest. 1994;94:1490-1495.
24. Soop M, Bjorkman O, Cederblad G, Hagenfeldt L, Wahren J. Influence of carnitine supplementation on muscle substrate and carnitine metabolism during exercise. J Appl Physiol. 1988;64: 2394-2399.
25. Chalmers RA, Roe CR, Stacey TE, Hoppel CL. Urinary excretion of L-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: evidence for secondary insufficiency of L-carnitine. Pediatr Res. 1984;18:1325-1328.