Incorporation of medium chain triacylglycerols into phospholipid bilayers: Effect of long chain triacylglycerols, cholesterol, and cholesteryl esters

Journal of Lipid Research

Volumn 37, Issue 4, 1996, Pages 773-782

  Hamilton, James A ^a   Vural, J M ^a   Carpentier, Yvon A ^c   Deckelbaum, Richard J ^b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^c SAINT PIERRE UNIVERSITY HOSPITAL   (Belgium)

Author keywords

13C NMR; emulsion; lipolysis; lipoprotein; parenteral feeding

Indexed keywords

CARBON 13; CHOLESTEROL; CHOLESTEROL ESTER; CHOLESTEROL OLEATE; LONG CHAIN TRIACYLGLYCEROL; MEDIUM CHAIN TRIACYLGLYCEROL; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; TRIOCTANOIN; TRIOLEIN;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; MEMBRANE VESICLE; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; SOLUBILITY;

CHOLESTEROL; CHOLESTEROL ESTERS; EMULSIONS; HYDROLYSIS; LIPASE; LIPID BILAYERS; LIPOSOMES; MAGNETIC RESONANCE SPECTROSCOPY; OCTANOIC ACIDS; PHOSPHOLIPIDS; SOLUBILITY; TRIGLYCERIDES; TRIOLEIN; WATER;

EID: 0029876314     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Desnuelle, P., J. Molines, and D. Dervichian. 1951. Sur l'hydratation des phospholipides au sein des glycerides. Bull. Soc. Chim. Fr. 18: 197-203.
2. Pieroni, G., and R. Verger. 1979. Hydrolysis of mixed macromolecular films of triglyceride/lecithin by pancreatic lipase. J. Biol. Chem. 254: 10090-10094.
3. Miller, K. W., and D. M. Small. 1987. Structure of triglyceride-rich lipoproteins: an analysis of core and surface phases. In Plasma Lipoproteins. A. M. Gotto, Jr., editor. Elsevier Science Publishers B. V., New York, 1-75.
4. 13C NMR study. Proc. Natl. Acad. Sci. USA. 78: 6878-6882.
5. Hamilton, J. A. 1989. Interactions of triglycerides with phospholipids: incorporation into the bilayer structure and formation of emulsions. Biochemistry. 28: 2514-2520.
6. Deckelbaum, R. J., J. A. Hamilton, A. Moser, G. Bengtsson-Olivecrona, E. Butbul, Y. Carpentier, A. Gutman, and T. Olivecrona. 1990. Medium-chain vs. long-chain triacylglycerol emulsion hydrolysis by lipoprotein lipase and hepatic lipase: implications for the mechanisms of lipase action. Biochemistry, 29: 1136-1142.
7. Sato, N., R. J. Deckelbaum, G. Neeser, Y. A. Carpentier, and J. M. Kinney. 1994. Hydrolysis of mixed lipid emulsions containing medium-chain and long-chain triacylglycerol with lipoprotein lipase in plasma-like medium. J. Parenter. Enteral. Nutr. 18: 112-118.
8. Greenberger, N. J., and T. G. Skillman. 1969. Medium-chain triglycerides. Physiologic considerations and clinical implications. N. Engl. J. Med. 280: 1045-1058.
9. Ashbrook, J. D., A. A. Spector, and J. E. Fletcher. 1972. Medium chain fatty acid binding to human plasma albumin. J. Biol. Chem. 247: 7038-7042.
10. 14C)oleate monolayers by postheparin lipolytic activity. J. Lipid Res. 13: 769-776.
11. Férézou, J., N-T. Lai, C. Leray, T. Hajri, A. Frey, Y. Cabaret, J. Courtieu, C. Lutton, and A. C. Bach. 1994. Lipid composition and structure of commercial parenteral emulsion. Biochim. Biophys. Acta. 1213: 149-158.
12. Hamilton, J. A., and D. M. Small. 1982. Solubilization and localization of cholesteryl oleate in egg phosphatidylcholine vesicles: a carbon-13 NMR study. J. Biol. Chem. 257: 7318-7321. (Communication)
13. Hamilton, J. A., K. W. Miller, and D. M. Small. 1983. Solubilization of triolein and cholesteryl oleate in egg phosphatidylcholine vesicles. J. Biol. Chem. 258: 12821-12826.
14. 1H magic angle spinning NMR study. Biochemistry. 32: 9038-9052.
15. Mims, M. M., and J. D. Morrisett. 1988. The role of cholesterol and cholesteryl ester in the structure, dynamics, and metabolism of plasma lipoproteins. In Biology of Cholesterol. P. L. Yeagle, editor. CRC Press, Boca Raton, FL. 71-94.
16. Miller, K. W., and D. M. Small. 1983. Surface-to-core and interparticle equilibrium distributions of triglyceride-rich lipoprotein lipids. J. Biol. Chem. 258: 13772-13784.
17. Spooner, P. J. R., and D. M. Small. 1987. Effect of free cholesterol on incorporation of triolein in phospholipid bilayers. Biochemistry. 26: 5820-5825.
18. 13C-NMR study. Biochim. Biophys. Acta. 860: 345-353.
19. 13C NMR study. Biochemistry. 30: 2894-2902.
20. Richelle, M., Y. A. Carpentier, and R. J. Deckelbaum. 1994. Long- and medium-chain triacylglycerols in neutral lipid-exchange processes with human plasma low-density lipoproteins. Biochemistry. 33: 4872-4878.
21. Heird, W. C., S. M. Grundy, and V. S. Hubbard. 1986. Structured lipids and their use in clinical nutrition. Am. J. Clin. Nutr. 43: 320-324.
22. Ikeda, I., Y. Tomari, M. Sugano, S. Watanabe, and J. Nagata. 1991. Lymphatic absorption of structured glycerolipids containing medium-chain fatty acids and linoleic acid, and their effect on cholesterol absorption in rats. Lipids. 26: 369-373.
23. Bell, S. J., E. A. Mascioli, B. R. Bistrian, V. K. Babayan, and G. L. Blackburn. 1991. Alternative lipid sources for enteral and parenteral nutrition: long- and medium-chain triglycerides, structured triglycerides, and fish oils. J. Am. Diet. Assoc. 91: 74-78.