Evidence that a nereistoxin metabolite, and not nereistoxin itself, reduces neuronal nicotinic receptors: Studies in the whole chick ciliary ganglion, on isolated neurons and immunoprecipitated receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 1, 1996, Pages 169-177

  Xie, Yu ^a,b   Mchugh, Tara ^a   Mckay, Judith ^a   Jones Jr , Gerald S ^a,c   Loring, Ralph H ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOACETYLCHOLINE; DITHIOTHREITOL; DRUG METABOLITE; NICOTINIC RECEPTOR; NITROBENZOIC ACID DERIVATIVE; RECEPTOR SUBTYPE;

ALPHA CHAIN; ANIMAL TISSUE; ARTICLE; BINDING SITE; CHICKEN; CILIARY GANGLION; DISULFIDE BOND; DRUG EFFECT; DRUG RECEPTOR BINDING; IMMUNOPRECIPITATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RECEPTOR BLOCKING;

ACETYLCHOLINE; ANIMALS; CELLS, CULTURED; CHICKENS; GANGLIA, PARASYMPATHETIC; HYDROGEN-ION CONCENTRATION; MARINE TOXINS; NEURONS; OXIDATION-REDUCTION; PRECIPITIN TESTS; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, NICOTINIC; SULFHYDRYL COMPOUNDS; THIOPHENES;

EID: 0029876312     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. AOSHIMA, H., HORI, K. AND YAMAMOTO, A.: Acetylcholine receptor-controlled ion translocation caused by phenyltrimethylammonium and nereistoxin: Simple estimation of equilibrium constants of the minimal model. J. Biochem. (Tokyo) 101: 347-355, 1987.
2. ASAHI, Y. AND YUSHIDA, T.: Kinetics of hydrolysis of insecticides: Cartap hydrochloride and nereistoxin. Chem. Pharm. Bull. 25: 2211-2216, 1974.
3. BARTELS, E., DEAL, W., KARLIN, A. AND MAUTNER, H. G.: Affinity oxidation of the reduced acetylcholine receptor. Biochim. Biophys. Acta 203: 568-571, 1970.
4. BERG, D. K., BOYD, R. T., HALVORSEN, S. W., HIGGINS, L. S., JACOB, M. H AND MARGIOTTA, J. F.: Regulating the number and function of neuronal acetylcholine receptors. Trends Neurosci. 12: 16-21, 1989.
5. BREGESTOVSKI, P. D., ILJIN, V. I., JURCHENKO, O. P., VEPRINTSEV, B. N. AND VULFIUS, C. A.: Acetylcholine receptor conformational transition on excitation masks disulfide bonds against reduction. Nature 270: 71-73, 1977.
6. CHIOU, C.-Y. AND SASTRY, B. V. R.: Acetylcholinesterase hydrolysis of halogen substituted acetylcholines. Biochem. Pharm. 17: 805-815, 1968.
7. DEGUCHI, T, NARAHASHI, T. AND HAAS, H. G.: Mode of action of nereistoxin on neuromuscular transmission in the frog. Pestic. Biochem. Physiol. 1: 196-204, 1971.
8. DOU, Y., MCHUGH, T., LANE, W. V., ROSSANT, C. J. AND LORING, R. H.: Interactions of dithiols with p-aminophenyldichloroarsine and nicotinic acetylcholine receptors. J. Biol. Chem. 269: 20410-20416, 1994.
9. - conductance response to TRH following patch recording can be obviated with GH3 cell extract. Biochem Biophys. Res. Commun. 137: 388-396, 1986.
10. ELDEFRAWI, A T., BAKRY, N. M , ELDEFRAWI, M. E , TSAI, M.-C. AND ALBUQUERQUE, E. X.: Nereistoxin interaction with the acetylcholine receptor-ionic channel complex. Mol. Pharm. 17: 172-179, 1980.
11. ELLMAN, G. L.: Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82: 70-77, 1959.
12. FISHER, D. H., XIE, Y. AND LORING, R : Analysis of nereistoxin using HPLC and electro-chemical detection. Anal. Lett. 26: 1051-1063, 1993.
13. FORSCHER, P. AND OXFORD, G. S.: Modulation of calcium channels by norepinephrine in internally dialyzed avian sensory neurons. J. Gen. Physiol. 85: 743-763, 1985.
14. HASHIMOTO, Y. AND OKAICHI, T.: Some chemical properties of nereistoxin. Ann. N.Y. Acad. Sci. 90: 667-673, 1960.
15. HORN, R. AND MARTY, A.: Muscarinic activation of ionic currents measured by a new whole-cell recording method J. Gen. Physiol. 92: 145-159, 1988.
16. KARLIN, A.: Explorations of the nicotirac acetylcholine receptor. Harvey Lect. 85: 71-107, 1991.
17. KARLIN, A. AND BARTELS, E.: Effects of blocking sulfhydryl groups and of reducing disulfide bonds on the acetylcholine-activated permeability system of the electroplax. Biochim. Biophys. Acta 126: 525-535, 1966.
18. KEYSER, K. T., BRITTO, L. R. G., SCHOEPFER, R., WHITING, P., COOPER, J., CONROY, W., BROZOZOWSKA-PRECHTL, A., KARTEN, H. J. AND LINDSTROM, J.: Three subtypes of α-bungarotoxin-sensitive nicotinic acetylcholine receptors are expressed in chick retina. J. Neurosci. 13: 442-454, 1993.
19. KONISHI, K.: Nereistoxin and its relatives. 2nd Int. Cong. Pestic. Chem. 2: 179-189, 1971.
20. LORING, R. H., CHIAPPINELLI, V. A., ZIGMOND, R. E. AND COHEN, J. B.: Characterization of a snake venom neurotoxin which blocks nicotinic transmission in avian ciliary ganglion. Neuroscience 11: 989-999, 1984.
21. LORING, R. H., AIZENMAN, E., LIPTON, S. A. AND ZIGMOND, R. E : Characterization of nicotinic receptors in chick retina using a snake venom neurotoxin that blocks neuronal nicotinic receptor function. J. Neurosci. 9: 2423-2431, 1989.
22. LORING, R. H.: The molecular basis of curaremimetic snake neurotoxin specificity for neuronal nicotinic receptor subtypes. J. Toxicol. Toxin Rev. 12: 105-153, 1993.
23. MARTIN, A. R. AND PILAR, G.: Transmission through the ciliary ganglion of the chick. J. Physiol. (Lond.) 168: 464-475, 1963a.
24. MARTIN, A. R. AND PILAR, G.: Dual mode of synaptic transmission in the avian ciliary ganglion. J. Physiol. (Lond.) 168: 443-463, 1963b.
25. MCEACHERN, A. E., JACOB, M. H. AND BERG, D. K.: Differential effects of nerve tran section on the ACh and GABA receptors of chick ciliary ganglion neurons. J. Neurosci. 9: 3899-3907, 1989.
26. NAGAWA, Y., SAJI, Y., CHIBA, S. AND YUI, T.: Neuromuscular blocking actions of nereistoxin and its derivatives and antagonism by sulfhydryl compounds. Jpn. J. Pharmacol. 21: 185-197, 1971.
27. RAVDIN, P. M. AND BERG, D. K.: Inhibition of neuronal acetylcholine sensitivity by α-toxins from Bungarus multicinctus venom. Proc. Natl. Acad. Sci. U.S.A. 76: 2072-2076, 1979.
28. RAY, D. E., Pesticides derived from plants and other organisms. In Handbook of Pesticide Toxicology, Vol. 2, ed. by W. J. Hayes, Jr. and E. R. Laws, Jr., pp. 585-636, Academic Press, San Diego, CA, 1991.
29. RITCHIE, J. M AND GREENGAHD, P.: On the mode of action of local anesthetics. In Annual Review of Pharmacology, ed. by H. W. Elliot, pp. 405-430, Annual Reviews, Inc., Palo Alto, CA, 1966.
30. ROLE, L. W.: Diversity in primary structure and function of neuronal nicotinic acetylcholine receptor channels. Curr. Opin. Neurobiol. 2: 254-262, 1992.
31. ROSSANT, C. J., LINDSTROM, J. AND LORING, R. H.: Effects of redox reagents and arsenical compounds on [3H]-cytisine binding to immunoisolated nicotinic acetylcholine receptors from chick brain containing α4βZ subunits. J. Neurochem. 62: 1368-1374, 1994.
32. SAKAI, M. AND SATO, Y.: Metabolic conversion of nereistoxin-related compounds into nereistoxin as a factor of their insecticidal action. 2nd Int. Cong. Pestic. Chem. 2: 455-467, 1971.
33. SATTELLE, D. B., HARROW, I. D., DAVID, J. A., PELHATE, M., CALLEC, J. J., GEPNER, J. I. AND HALL, L. M.: Nereistoxin: Actions on a CNS acetylcholine receptor/ion channel in the cockroach Periplaneta americana. J. Exp. Biol. 118: 37-52, 1985.
34. SORENSON, E. M. AND GALLAGHER, J. P.: The reducing agent dithiothreitol (DTT) does not abolish the inhibitory nicotinic response recorded from rat dorsolateral septal neurons. Neurosci. Lett 152: 137-140, 1993.
35. SWANSON, K. L. AND ALBUQUERQUE, E. X.: Nicotinic acetylcholine receptors and low molecular weight toxins. In Handbook of Experimental Pharmacology, Vol. 102, Selective Neurotoxicity, ed. by H. Herken and F. Hucho, pp. 611-658, Springer Verlag, Berlin, 1992.
36. TRAUTMANN, A. AND MARTY, A.. Activation of Ca-dependent K channels by carbamoylcholine in rat lacrimal glands. Proc. Natl. Acad. Sci. U.S.A. 81: 611-615, 1984.
37. VERNALLIS, A. B., CONROY, W. G. AND BERG, D. K.. Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes. Neuron 10: 451-464, 1993.
38. WHITING, P. J., SCHOEPFER, R., CONBOY, W. G., GORE, M. J., KEYSER, K. T., SHIMASAKI, S., ESCH, F. AND LINDSTROM, J. M.: Expression of nicotinic acetylcholine receptor subtypes in brain and retina. Mol. Brain Res. 10: 61-70, 1991.
39. XIE, Y., JONES, G. S., JR. AND LORING, R H.: Effects of oxidizing and reducing analogs of acetylcholine on neuronal nicotimc receptors. Mol. Pharmacol. 42: 356-363, 1992a.
40. XIE, Y., TANG, L.-H., AIZENMAN, E. AND LORING, R. H.: Redox effects of nereistoxin on neuronal nicotinic receptors (nAChRs) of chick ciliary ganglion (Abstract). Soc. Neurosci. Abstr. 18: 801, 1992b.
41. XIE, Y., LANE, W. V. AND LORING, R. H.: Nereistoxin. A naturally occurring toxin with redox effects on neuronal nicotinic acetylcholine receptors in chick retina. J. Pharmacol. Exp. Ther. 264: 689-694, 1993a.
42. XIE, Y., LORING, R. H. AND JONES, G. S., JR.: The reduced form of nereistoxin is responsible for redox effects on neuronal nicotinic receptors (nAChRs) (Abstract). Soc. Neurosci. Abstr. 19: 1534, 1993b