Evidence for an in vivo and in vitro modulation of endogenous cortical GABA release by α-glycerylphosphorylcholine

Neurochemical Research

Volumn 21, Issue 5, 1996, Pages 547-552

  Ferraro, L ^a   Tanganelli, S ^b   Marani, L ^a   Bianchi, C ^a   Beani, L ^a   Siniscalchi, A ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

cortical slices; Epidural cups; GABA release; neurotransmitter interactions; rat

Indexed keywords

4 AMINOBUTYRIC ACID; ATROPINE; GLYCEROPHOSPHORYLCHOLINE; MECAMYLAMINE; MUSCARINIC RECEPTOR; NICOTINIC RECEPTOR; PRAZOSIN; TETRODOTOXIN;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLINERGIC NERVE CELL; COGNITIVE DEFECT; DRUG RECEPTOR BINDING; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MEMORY; NEUROTRANSMISSION; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; RAT;

ANIMALS; ATROPINE; CEREBRAL CORTEX; DRUG SYNERGISM; GAMMA-AMINOBUTYRIC ACID; GLYCERYLPHOSPHORYLCHOLINE; INJECTIONS, INTRAPERITONEAL; KINETICS; MALE; MECAMYLAMINE; PRAZOSIN; RATS; RATS, SPRAGUE-DAWLEY; TETRODOTOXIN;

EID: 0029875896     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02527751     Document Type: Article

References (31)

1. Bartus, R. T., Dean, R. L., Beer, B., and Lippa, A. S. 1982. The cholinergic hypothesis of geriatric memory disfunction. Science 217:408-417.
2. Fischer, W., Gage, F. H., and Bjorklund, A. 1989. Degenerative changes in forebrain cholinergic nuclei correlate with cognitive impairments in aged rats. Eur. J. Neurosci. 1:34-41.
3. Mayeux, R. 1990. Therapeutic strategies in Alzheimer's disease. Neurology 40:175-179.
4. O'Neill, C., Marcusson, J., Nordberg, A., and Winblad, B. 1987. The influence of age on neurotransmitters in the human brain. Pages 183-198, in Govoni, S., and Battaini, F. (eds.). Modification of cell to cell signals during normal and pathological aging. Springer-Verlag, Berlin, Heidelberg.
5. Finali, G., Piccinin, M., and Piccirilli, M. 1992. Le basi neurochimiche della terapia farmacologica delle demenze. Parte seconda: aminoacidi e peptidi. Basi Raz. Ter. 22 (2):99-121.
6. Nabeshima, T., Noda, Y., Tohyama, K., Itoh, J., and Kameyama, T. 1990. Effects of DM-9384 in a model of amnesia based on animals with GABAergic neuronal dysfunctions. Eur. J. Pharmacol. 178:143-149.
7. Manyan, N. B., Katz, L., Hare, T. A., Gerber, J. C., and Grossman, M. H. 1980. Levels of γ-aminobutyric acid in cerebrospinal fluid in various neurologic disorders. Arch. Neurol. 37:352-355.
8. Zimmer, R., Teelken, A. W., Trieling, W. B., Weber, W., Weihmayr, T., and Lauter, H. 1984. γ-aminobutyric acid and homovanillic acid concentration in the CNS of patients with senile dementia of Alzheimer's type. Arch. Neurol. 41:602-604.
9. Sharma, A. C., and Kulkami, S. K. 1993. Baclofen sensitive scopolamine-induced short-term deficits in mice. Indian J. Exp. Biol. 31:348-352.
10. Davies, C. H., Starkey, S. J., Pozza, M. F., and Collingride, G. L. 1991. GABA-B autoreceptors regulate the induction of LTP. Nature 349:609-611.
11. Izquierdo, I. 1991. Role of NMDA receptors in memory. Trends Pharmacol. Sci. 12:128-129.
12. Sigala, S., Imperato, A., Rizzonelli, P., Casolini, P., Missale, C., and Spano, P. F. 1992. L-alpha-glycerylphosphorylcholine antagonizes scopolamine-induced amnesia and enhances hippocampal cholinergic transmission in the rat. Eur. J. Pharmacol. 211:351-358.
13. Lopez, C. M., Govoni, S., Battaini, F., Bergamaschi, S., Longoni, A., Giaroni, C., and Trabucchi, M. 1991. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. Pharmacol. Biochem. Behav. 39:835-840.
14. Canal, N., Franceschi, M., Alberoni, M., Castiglioni, C., De Moliner, P., and Longoni, A. 1991. Effect of L-alpha-glycerylphosphoryl-choline on amnesia caused by scopolamine. Int. J. Clin. Pharmacol. Ther. Toxicol. 29:103-107.
15. Pametti, L., Abate, G., Bartorelli, L., Cucinotta, D., Cuzzupuli, M., Maggioni, M., Villardita, C., and Senin, U. 1993. Multicentre study of 1-α-Glyceryl-Phosphorylcholine vs ST200 among patients with probable senile dementia of Alzheimer's Type. Drugs Aging 3:159-164.
16. Beani, L., Bianchi, C., Santinoceto, L., and Marchetti, P. 1968. The cerebral acetylcholine release in conscious rabbits with semipermanently implanted epidural cups. Int. J. Neuropharmacol. 7: 469-481.
17. 1A receptor agonist, on cortical acetylcholine release, electrocorticogram and body temperature in guinea pigs and rats. Eur. J. Pharmacol. 175:219-223.
18. Tanganelli, S., Ferraro, L., Bianchi, C., and Beani, L. 1992. Changes in gamma-aminobutyric acid release induced by topical administration of drugs affecting its metabolism and receptors: studies in freely moving guinea pigs with epidural cups. Neurochem. Int. 21:15-20.
19. Beani, L., Bianchi, C., Giacomelli, A., and Tamberi, F. 1978. Noradrenaline inhibition of acetylcholine release from guinea pig brain. Eur. J. Pharmacol. 48:179-193.
20. Ferraro, L., Tanganelli, S., Calo', G., Antonelli, T., Fabrizi, A., Acciarri, N., Bianchi, C., Beani, L., and Simonato, M. 1993. Noradrenergic modulation of γ-aminobutyric acid outflow from the human cerebral cortex. Brain Res. 629:103-108.
21. Bertilsson, L., and Costa, E. 1976. Mass-fragmentographic quantitation of glutamic acid and GABA in cerebellar nuclei and sympathetic ganglia of rats. J. Chromatogr. 118:395-399.
22. Moroni, F., Tanganelli, S., Antonelli, T., Carla', V., Bianchi, C., and Beani, L. 1983. Modulation of cortical acetylcholine and γ-aminobutyric acid release in freely moving guinea pigs: effect of clonidine and other adrenergic drugs. J. Pharmac. Exp. Ther. 227: 435-440.
23. Bianchi, C., Ferraro, L., Tanganelli, S., Morari, M., Spalluto, G., Simonato, M., and Beani, L. 1995. 5-Hydroxytryptamine-mediated effects of nicotine on endogenous GABA efflux from guinea-pig cortical slices. Br. J. Pharmacol. 116:2724-2728.
24. Raiteri, M., Marchi, M., Paudice, P., and Pittaluga, A. 1990. Muscarinic receptors mediating inhibition of gamma-aminobutyric acid release in rat corpus striatum and their pharmacological characterization. J. Pharmacol. Exp. Ther. 254:498-501.
25. 2) mediated inhibition of the electrically-evoked endogenous GABA release from guinea pig cerebral cortex slices. Pol. J. Pharmacol. 46:308-309.
26. Beani, L., Tanganelli, S., Antonelli, T., and Bianchi, C. 1986. Noradrenergic modulation of cortical acetylcholine release is both direct and γ-aminobutyric acid-mediated. J. Pharmacol. Exp. Ther. 236:230-236.
27. Beani, L., Bianchi, C., Tanganelli, S., Antonelli, T., Simonato, M., and Rando, S. 1988. Inversion of alpha-2 and alpha-1 noradrenergic control of the cortical release of acetylcholine and gamma-aminobutyric acid in morphine-tolerant guinea pigs. J. Pharmacol. Exp. Ther. 247:294-301.
28. Mason, S. T., and Fibiger, H. C. 1979. Possible behavioural function for noradrenaline-acetylcholine in brain. Nature 277:396-397.
29. Ennis, M., and Aston-Jones, G. 1988. Activation of Locus Coeruleus from Nucleus Paragigantocellularis: a new excitatory amino acid pathway in brain. J. Neurosci. 8:3644-3657.
30. Bianchi, C., Tanganelli, S., Marzola, G., and Beani, L. 1982. GABA induced changes in acetylcholine release from slices of guinea pig brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 318: 253-258.
31. Govoni, S., Lucchi, L., Battaini, F., and Trabucchi, M. 1992. Protein-kinase C increase in rat brain cortical membranes may be promoted by cognition enhancing drugs. Life Sci. 50:125-128.