메뉴 건너뛰기




Volumn 42, Issue 2, 1996, Pages 87-96

Melatonin as an antiaging drug: Between facts and fantasy

Author keywords

Aging; Brain; Immune system; Melatonin; Radical scavenger; Side effects

Indexed keywords

HORMONE; MELATONIN; REACTIVE OXYGEN METABOLITE; SCAVENGER;

EID: 0029875860     PISSN: 0304324X     EISSN: 14230003     Source Type: Journal    
DOI: 10.1159/000213777     Document Type: Article
Times cited : (20)

References (67)
  • 3
    • 0018995028 scopus 로고
    • The pineal and its hormones in the regulation of reproduction in mammals
    • Reiter RJ: The pineal and its hormones in the regulation of reproduction in mammals. Endocr Res 1980: 1:109-131.
    • (1980) Endocr Res , vol.1 , pp. 109-131
    • Reiter, R.J.1
  • 4
    • 0015551544 scopus 로고
    • Comparative physiology: Pineal gland
    • Reiter RJ: Comparative physiology: Pineal gland. Annu Rev Physiol 1973;35:305-328.
    • (1973) Annu Rev Physiol , vol.35 , pp. 305-328
    • Reiter, R.J.1
  • 5
    • 0024342306 scopus 로고
    • Central melatonin receptors: Implications for a mode of action
    • Morgan PJ, Williams LM: Central melatonin receptors: Implications for a mode of action. Expcrientia 1989:45:955-965.
    • (1989) Expcrientia , vol.45 , pp. 955-965
    • Morgan, P.J.1    Williams, L.M.2
  • 6
    • 0001767885 scopus 로고
    • Melatonin: The internal zeitgeber of mammals?
    • Armstrong S: Melatonin: The internal zeitgeber of mammals? Pineal Res Rev 1989:7:157-202.
    • (1989) Pineal Res Rev , vol.7 , pp. 157-202
    • Armstrong, S.1
  • 7
    • 0022469485 scopus 로고
    • Entrainment of rat circadian rhythms by daily injections of melatonin depend upon the hypothalamic suprachiasmatic nuclei
    • Cassone VM, Chesworth MJ, Armstrong SM: Entrainment of rat circadian rhythms by daily injections of melatonin depend upon the hypothalamic suprachiasmatic nuclei. Physiol Behav 1986:36:111-116.
    • (1986) Physiol Behav , vol.36 , pp. 111-116
    • Cassone, V.M.1    Chesworth, M.J.2    Armstrong, S.M.3
  • 9
    • 0000611823 scopus 로고
    • Melatonin: That ubiquitously acting pineal hormone
    • Reiter RJ: Melatonin: That ubiquitously acting pineal hormone. News Physiol Sci 1991 b;6:223-227.
    • (1991) News Physiol Sci , vol.6 , pp. 223-227
    • Reiter, R.J.1
  • 10
    • 0027301992 scopus 로고
    • Calmodulin mediates melatonin cyto-skeletal effects
    • Benitz-King G, Anton-Tay F: Calmodulin mediates melatonin cyto-skeletal effects. Experientia 1993: 49:635-641.
    • (1993) Experientia , vol.49 , pp. 635-641
    • Benitz-King, G.1    Anton-Tay, F.2
  • 11
    • 0028286712 scopus 로고
    • Specific binding of melatonin by immunocompetent cells in humans and rodents
    • Guerrero JM, Lopcz-Gonzalez MA, Osuna C, Calvo JR: Specific binding of melatonin by immunocompetent cells in humans and rodents. Ann NY Acad Sci 1994;719:369-377.
    • (1994) Ann NY Acad Sci , vol.719 , pp. 369-377
    • Guerrero, J.M.1    Lopcz-Gonzalez, M.A.2    Osuna, C.3    Calvo, J.R.4
  • 13
    • 0029268538 scopus 로고
    • On the primary functions of melatonin in evolution: Mediation of photo-periodic signals in a unicell, photooxidation. And scavenging of free radicals
    • Hardeland R, Balzer I, Poeggeler B, Fuhrbcrg B, Uria H, Behrmann G, Wolf R, Meyer TJ, Reiter RJ: On the primary functions of melatonin in evolution: Mediation of photo-periodic signals in a unicell, photooxidation. and scavenging of free radicals. J Pineal Res 1995; 18:104-111.
    • (1995) J Pineal Res , vol.18 , pp. 104-111
    • Hardeland, R.1    Balzer, I.2    Poeggeler, B.3    Fuhrbcrg, B.4    Uria, H.5    Behrmann, G.6    Wolf, R.7    Meyer, T.J.8    Reiter, R.J.9
  • 14
    • 0023116596 scopus 로고
    • Melatonin. 5-methoxytryptamine and some of their analogs as cyclooxygenase inhibitors in rat medial basal hypothalamus
    • Franchi AM, Gimeno MF, Cardi-nani DP, Valas MJ: Melatonin. 5-methoxytryptamine and some of their analogs as cyclooxygenase inhibitors in rat medial basal hypothalamus. Brain Res 1987:405:384-388.
    • (1987) Brain Res , vol.405 , pp. 384-388
    • Franchi, A.M.1    Gimeno, M.F.2    Cardi-Nani, D.P.3    Valas, M.J.4
  • 15
    • 0028177147 scopus 로고
    • The antigonadotrophic effect of melatonin in Syrian hamsters is modulated by prostaglandin
    • Nir I, Schmidt U, Zilber N: The antigonadotrophic effect of melatonin in Syrian hamsters is modulated by prostaglandin. J Neural Transm [Gen. Sect] 1994:95:173-177.
    • (1994) J Neural Transm [Gen. Sect] , vol.95 , pp. 173-177
    • Nir, I.1    Schmidt, U.2    Zilber, N.3
  • 16
    • 0001327186 scopus 로고
    • Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum
    • Pozo D, Reiter RJ, Calvo JM, Guerrero JM: Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sci 1994;55:PL455-PL460.
    • (1994) Life Sci , vol.55 , pp. PL455-PL460
    • Pozo, D.1    Reiter, R.J.2    Calvo, J.M.3    Guerrero, J.M.4
  • 18
    • 0026668767 scopus 로고
    • Effect of tryptophan administration on circulating melatonin levels in chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract
    • Huether G, Poeggeler B, Reimcr A. George A: Effect of tryptophan administration on circulating melatonin levels in chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract. Life Sci 1992:51:945-953.
    • (1992) Life Sci , vol.51 , pp. 945-953
    • Huether, G.1    Poeggeler, B.2    Reimcr, A.3    George, A.4
  • 19
    • 0027313442 scopus 로고
    • The contribution of ex-trapincal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates
    • Huether G: The contribution of ex-trapincal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates. Experientia 1993:49:665-670.
    • (1993) Experientia , vol.49 , pp. 665-670
    • Huether, G.1
  • 20
    • 0026495557 scopus 로고
    • The metabolic fate of infused β-tryptophan in men: Possible clinical implications of the accumulation of circulating tryptophan and tryptophan metabolites
    • Huether G, Hajak G, Reimer A, Poeggeler B, BImer M, Rodenbeck A, Rüther E: The metabolic fate of infused β-tryptophan in men: Possible clinical implications of the accumulation of circulating tryptophan and tryptophan metabolites. Psychopharmacology 1992:106:442- 432.
    • (1992) Psychopharmacology , vol.106
    • Huether, G.1    Hajak, G.2    Reimer, A.3    Poeggeler, B.4    Bimer, M.5    Rodenbeck, A.6    Rüther, E.7
  • 21
    • 0025187950 scopus 로고
    • Regulatory sites in the melatonin system of mammals
    • Krause DN, Dubocovich ML: Regulatory sites in the melatonin system of mammals. Trends Neurol Sci 1990:13:464-470.
    • (1990) Trends Neurol Sci , vol.13 , pp. 464-470
    • Krause, D.N.1    Dubocovich, M.L.2
  • 23
    • 0019809940 scopus 로고
    • Age and mental health related circadian rhyt hrns of plasma levels of melatonin, prolactin, luteinizing hormone and follicle stimulating hormone
    • Touitou Y, Fevre M. Lagugvcy M, Carayon A, Boydon A, Reinherl A: Age and mental health related circadian rhyt hrns of plasma levels of melatonin, prolactin, luteinizing hormone and follicle stimulating hormone. J Endocrinol 1981:91:367-375.
    • (1981) J Endocrinol , vol.91 , pp. 367-375
    • Touitou, Y.1    Fevre, M.2    Lagugvcy, M.3    Carayon, A.4    Boydon, A.5    Reinherl, A.6
  • 25
    • 0027325651 scopus 로고
    • Effects of indirectly acting 5-HT receptor agonists on circulating melatonin levels in rats
    • Huether G, Poeggeler B, Adler L. Rüther E: Effects of indirectly acting 5-HT receptor agonists on circulating melatonin levels in rats. Eur J Pharmacol 1993;238:249-254.
    • (1993) Eur J Pharmacol , vol.238 , pp. 249-254
    • Huether, G.1    Poeggeler, B.2    Adler, L.3    Rüther, E.4
  • 27
    • 0028362803 scopus 로고
    • Melatonin synthesis in the gastrointestinal tract and the impact of nutritional factors on circulating melatonin
    • Huether G: Melatonin synthesis in the gastrointestinal tract and the impact of nutritional factors on circulating melatonin. Ann NY Acad Sci 1994:719:146-158.
    • (1994) Ann NY Acad Sci , vol.719 , pp. 146-158
    • Huether, G.1
  • 28
    • 0026377775 scopus 로고
    • The pineal control of aging: The effects of melatonin and pineal grafting on the survival of older mice
    • Pierpaoli W, Dall'Ara A, Pedrinis E, Regelson W: The pineal control of aging: The effects of melatonin and pineal grafting on the survival of older mice. Ann NY Acad Sci 1991; 621:291-313.
    • (1991) Ann NY Acad Sci , vol.621 , pp. 291-313
    • Pierpaoli, W.1    Dall'ara, A.2    Pedrinis, E.3    Regelson, W.4
  • 29
    • 0027952777 scopus 로고
    • Pineal control of aging: Effect of melatonin and pineal grafting in aging mice
    • Pierpaoli W, Regelson W: Pineal control of aging: Effect of melatonin and pineal grafting in aging mice. Proc Natl Acad Sci USA 1994:91: 787-791.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 787-791
    • Pierpaoli, W.1    Regelson, W.2
  • 30
    • 0027185939 scopus 로고
    • Transplantation of the mammalian pineal gland: Studies on survival, revascularization. Reinncrvation, and recovery of function
    • Wu W, Scott ED, Reiter RJ: Transplantation of the mammalian pineal gland: Studies on survival, revascularization. reinncrvation, and recovery of function. Exp Neurol 1993; 122;88-99.
    • (1993) Exp Neurol , vol.122 , pp. 88-99
    • Wu, W.1    Scott, E.D.2    Reiter, R.J.3
  • 31
    • 0023810955 scopus 로고
    • Pineal melatonin: Its fundamental immunoregulatory role in aging and cancer
    • Maestroni GJM, Conti A, Pierpaoli KW: Pineal melatonin: Its fundamental immunoregulatory role in aging and cancer. Ann NY Acad Sci 1988:521:140-148.
    • (1988) Ann NY Acad Sci , vol.521 , pp. 140-148
    • Maestroni, G.1    Conti, A.2    Pierpaoli, K.W.3
  • 33
    • 0023935096 scopus 로고
    • Food restriction in rodents: An evaluation of its role in aging
    • Masoro EJ: Food restriction in rodents: An evaluation of its role in aging. J Gerontol 1988;43:B59-B64.
    • (1988) J Gerontol , vol.43 , pp. B59-B64
    • Masoro, E.J.1
  • 36
    • 0028137186 scopus 로고
    • Melatonin: A peroxyl radical scavenger more effective than vitamin E
    • Pieri C, Marra M, Moroni F, Rec-chioni R, Marche-Selli F: Melatonin: A peroxyl radical scavenger more effective than vitamin E. Life Sci 1994;55:PL271-PL276.
    • (1994) Life Sci , vol.55 , pp. PL271-PL276
    • Pieri, C.1    Marra, M.2    Moroni, F.3    Rec-Chioni, R.4    Marche-Selli, F.5
  • 38
    • 0028178826 scopus 로고
    • Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole
    • Tan DX, Reiter RJ, Chen LD, Pocg-gelcr B, Manchester LC, Barlow-Walden L.R: Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole. Carcinogenesis 1994; 15:215-218.
    • (1994) Carcinogenesis , vol.15 , pp. 215-218
    • Tan, D.X.1    Reiter, R.J.2    Chen, L.D.3    Pocg-Gelcr, B.4    Manchester, L.C.5    Barlow-Walden, L.R.6
  • 39
    • 0028983511 scopus 로고
    • Melatonin protects human blood lymphocytes from radiation-induced chromosome damage
    • Vijayalaxnti B. Reiter RJ. Meltz ML: Melatonin protects human blood lymphocytes from radiation-induced chromosome damage. Mutât Res 1995:346:23-31.
    • (1995) Mutât Res , vol.346 , pp. 23-31
    • Vijayalaxnti, B.1    Reiter, R.J.2    Meltz, M.L.3
  • 41
    • 13344274241 scopus 로고
    • Inhibitory effect of melatonin on cataract formation in newborn rats: Evidence for an antioxidative role for melatonin in rats
    • Abc M, Reiter RJ, Orhil PB, Hara M, Poeggeler B: Inhibitory effect of melatonin on cataract formation in newborn rats: Evidence for an antioxidative role for melatonin in rats. Life Sci 1994:56:83-89.
    • (1994) Life Sci , vol.56 , pp. 83-89
    • Abc, M.1    Reiter, R.J.2    Orhil, P.B.3    Hara, M.4    Poeggeler, B.5
  • 42
    • 0028924029 scopus 로고
    • Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage in rats
    • Mclchiorri D, Reiter RJ, Attia AM, Hara M, Burgus A, Nistico G: Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage in rats. Life Sci 1994; 56:83-89.
    • (1994) Life Sci , vol.56 , pp. 83-89
    • McLchiorri, D.1    Reiter, R.J.2    Attia, A.M.3    Hara, M.4    Burgus, A.5    Nistico, G.6
  • 45
  • 46
  • 47
    • 0029055175 scopus 로고
    • Oxidative processes and antioxidative defense mechanisms in the aging brain
    • Reiter RJ: Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 1995:9: 526-533.
    • (1995) FASEB J , vol.9 , pp. 526-533
    • Reiter, R.J.1
  • 48
    • 0026768523 scopus 로고
    • Melatonin binding sites: Are they receptors?
    • Kennaway DJ, Hugel HM: Melatonin binding sites: Are they receptors? Mol Cell Endocrinol 1992;88:C1-C9.
    • (1992) Mol Cell Endocrinol , vol.88 , pp. C1-C9
    • Kennaway, D.J.1    Hugel, H.M.2
  • 49
    • 13344267057 scopus 로고    scopus 로고
    • Neuroprotective actions of melatonin
    • Allegri Filippinc G, Costa CVL (cds), New York. Plenum Press, in press
    • Giusti P: Neuroprotective actions of melatonin; in: Allegri Filippinc G, Costa CVL (cds): Recent Advances in Tryptophan Research. New York. Plenum Press, in press.
    • Recent Advances in Tryptophan Research
    • Giusti, P.1
  • 50
    • 0025833981 scopus 로고
    • Melatonin modifies the spontaneous multiunit activity recorded in several brain nuclei of freely behaving rats
    • Naranjo-Rodriguez EB, Prieto-Gomez B, Rcycs-Vazqucs C: Melatonin modifies the spontaneous multiunit activity recorded in several brain nuclei of freely behaving rats. Brain Res Bull 1991:27:595-600.
    • (1991) Brain Res Bull , vol.27 , pp. 595-600
    • Naranjo-Rodriguez, E.B.1    Prieto-Gomez, B.2    Rcycs-Vazqucs, C.3
  • 51
    • 0023813226 scopus 로고
    • Effects of melatonin on 2-deoxy [uC]-g!ucosc uptake within rat su-prachiasmatic nucleus
    • uC]-g!ucosc uptake within rat su-prachiasmatic nucleus. Am J Physiol 1988;255:R332-R337.
    • (1988) Am J Physiol , vol.255 , pp. R332-R337
    • Cassone, V.M.1    Roberts, M.H.2    Moore, R.Y.3
  • 53
    • 0025168007 scopus 로고
    • Central gabacrgic mechanisms as targets for melatonin activity in brain
    • Rosenstein RE, Cardinali DP: Central gabacrgic mechanisms as targets for melatonin activity in brain. Neu-rochem Int 1990:17:373-379.
    • (1990) Neu-Rochem Int , vol.17 , pp. 373-379
    • Rosenstein, R.E.1    Cardinali, D.P.2
  • 54
    • 0023693907 scopus 로고
    • Pharmacology and function of melatonin receptors
    • Dubocovich ML: Pharmacology and function of melatonin receptors. FASEB J 1988;2:2765-2773.
    • (1988) FASEB J , vol.2 , pp. 2765-2773
    • Dubocovich, M.L.1
  • 55
    • 0025332798 scopus 로고
    • Activation of melatonin receptor sites retarded the depletion of norepinephrine following inhibition of synthesis in the C3H/Mcn mouse hypothalamus
    • Fang JM, Dubocovich ML: Activation of melatonin receptor sites retarded the depletion of norepinephrine following inhibition of synthesis in the C3H/Mcn mouse hypothalamus. J Ncurochem 1990:55: 76-82.
    • (1990) J Ncurochem , vol.55 , pp. 76-82
    • Fang, J.M.1    Dubocovich, M.L.2
  • 56
    • 0024463092 scopus 로고
    • Melatonin modulates the sensitivity of 5-hydroxytryptamine-2-receptor-mcdiated sleep-wakefulncss regulation in the rat
    • Dugovic C, Leyscn JE, Wanquier A: Melatonin modulates the sensitivity of 5-hydroxytryptamine-2-receptor-mcdiated sleep-wakefulncss regulation in the rat. Neurosci Lett 1989; 104:320-325.
    • (1989) Neurosci Lett , vol.104 , pp. 320-325
    • Dugovic, C.1    Leyscn, J.E.2    Wanquier, A.3
  • 57
    • 0025821734 scopus 로고
    • Differential effects of pinealectomy on amygdala and hippocampus serotonin metabolism
    • Migucz J, Martin F, Aldcgunde M: Differential effects of pinealectomy on amygdala and hippocampus serotonin metabolism. J Pineal Res 1991:10:100-103.
    • (1991) J Pineal Res , vol.10 , pp. 100-103
    • Migucz, J.1    Martin, F.2    Aldcgunde, M.3
  • 58
    • 0026738013 scopus 로고
    • Melatonin treatment delays reproductive aging of female rat via the opiatergic system
    • Trcntini GP, Genazzani AR, Cri-scuolo M: Melatonin treatment delays reproductive aging of female rat via the opiatergic system. Neuroendocrinology 1992;56:364-370.
    • (1992) Neuroendocrinology , vol.56 , pp. 364-370
    • Trcntini, G.P.1    Genazzani, A.R.2    Cri-Scuolo, M.3
  • 59
    • 0025166184 scopus 로고
    • Effects of melatonin on vertebrate circadian systems
    • Cassonc VM: Effects of melatonin on vertebrate circadian systems. Trends Neurol Sci 1990; 13:457- 464.
    • (1990) Trends Neurol Sci , vol.13
    • Cassonc, V.M.1
  • 60
    • 84951651811 scopus 로고
    • The pineal gland: A circadian or seasonal aging clock
    • Pierpaoli W: The pineal gland: A circadian or seasonal aging clock. Aging (Milano) 1991;3:99-101.
    • (1991) Aging (Milano) , vol.3 , pp. 99-101
    • Pierpaoli, W.1
  • 61
    • 0023611401 scopus 로고
    • The pinal gland and the circadian, opiatergic, immunoregula-tory role of melatonin
    • Maestroni GJMA, Conti A, Pier-paoli W: The pinal gland and the circadian, opiatergic, immunoregula-tory role of melatonin. Ann NY Acad Sci 1987;496:67-77.
    • (1987) Ann NY Acad Sci , vol.496 , pp. 67-77
    • Maestroni, G.1    Conti, A.2    Pier-Paoli, W.3
  • 62
    • 0026753692 scopus 로고
    • The role of the opioids (Met-enkeph-alin and beta-endorphin), epithal-amin, melatonin, thymosin and norepinephrine in regulating colony-forming units for granulocytc-maco-phages in bone marrow cell cultures from intact and pinealectomized rats
    • Haidar C, Haussier D, Gupta D: The role of the opioids (met-enkeph-alin and beta-endorphin), epithal-amin, melatonin, thymosin and norepinephrine in regulating colony-forming units for granulocytc-maco-phages in bone marrow cell cultures from intact and pinealectomized rats. Biogenic Amines 1992:9:1-6.
    • (1992) Biogenic Amines , vol.9 , pp. 1-6
    • Haidar, C.1    Haussier, D.2    Gupta, D.3
  • 63
    • 0002578952 scopus 로고
    • The Pineal: An Oncostat-ic Gland?
    • Reiter RJ, New York, Raven Press
    • Blask DE: The Pineal: An Oncostat-ic Gland? In Reiter RJ (ed): The Pineal Gland. New York, Raven Press, 1984, pp 253-284.
    • (1984) The Pineal Gland , pp. 253-284
    • Blask, D.E.1
  • 64
    • 0002712137 scopus 로고
    • Pineal gland, cellular proliferation and neoplastic growth: A historical account
    • Gupta D, Reiter RJ (eds), Tübingen, Brain Research Promotions
    • Reiter RJ: Pineal gland, cellular proliferation and neoplastic growth: A historical account; in Gupta D, Reiter RJ (eds): The Pineal Gland and Cancer. Tübingen, Brain Research Promotions, 1988, pp 41-64.
    • (1988) The Pineal Gland and Cancer , pp. 41-64
    • Reiter, R.J.1
  • 65
    • 0027195663 scopus 로고
    • Antiproliferative effect of pineal indoles on cultured tumor cell lines
    • Sze SF, Ng TB, Liu WK: Antiproliferative effect of pineal indoles on cultured tumor cell lines. Pineal Res 1993:14:27-33.
    • (1993) Pineal Res , vol.14 , pp. 27-33
    • Sze, S.F.1    Ng, T.B.2    Liu, W.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.